ID   Y1063_MYCTU             Reviewed;         360 AA.
AC   P9WIY9; L0T771; O53411; P67098;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 35.
DE   RecName: Full=Uncharacterized NTE family protein Rv1063c;
GN   OrderedLocusNames=Rv1063c; ORFNames=MTV017.16c;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- SIMILARITY: Belongs to the NTE family. {ECO:0000305}.
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DR   EMBL; AL123456; CCP43814.1; -; Genomic_DNA.
DR   PIR; E70892; E70892.
DR   RefSeq; NP_215579.1; NC_000962.3.
DR   RefSeq; WP_003405642.1; NZ_NVQJ01000060.1.
DR   AlphaFoldDB; P9WIY9; -.
DR   SMR; P9WIY9; -.
DR   STRING; 83332.Rv1063c; -.
DR   PaxDb; P9WIY9; -.
DR   DNASU; 887128; -.
DR   GeneID; 887128; -.
DR   KEGG; mtu:Rv1063c; -.
DR   TubercuList; Rv1063c; -.
DR   eggNOG; COG1752; Bacteria.
DR   OMA; CSMPGLL; -.
DR   PhylomeDB; P9WIY9; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0004622; F:lysophospholipase activity; IEA:InterPro.
DR   GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0046470; P:phosphatidylcholine metabolic process; IEA:InterPro.
DR   InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR   InterPro; IPR001423; LysoPLipase_patatin_CS.
DR   InterPro; IPR002641; PNPLA_dom.
DR   Pfam; PF01734; Patatin; 1.
DR   SUPFAM; SSF52151; SSF52151; 1.
DR   PROSITE; PS51635; PNPLA; 1.
DR   PROSITE; PS01237; UPF0028; 1.
PE   1: Evidence at protein level;
KW   Hydrolase; Lipid degradation; Lipid metabolism; Reference proteome.
FT   CHAIN           1..360
FT                   /note="Uncharacterized NTE family protein Rv1063c"
FT                   /id="PRO_0000172534"
FT   DOMAIN          19..179
FT                   /note="PNPLA"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01161"
FT   REGION          251..282
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           50..54
FT                   /note="GXSXG"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01161"
FT   MOTIF           166..168
FT                   /note="DGA/G"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01161"
FT   ACT_SITE        52
FT                   /note="Nucleophile"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01161"
FT   ACT_SITE        166
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01161"
SQ   SEQUENCE   360 AA;  37523 MW;  F08C30CE6096D0F6 CRC64;
     MPAPAALRVR GSSSPRVALA LGSGGARGYA HIGVIQALRE RGYDIVGIAG SSMGAVVGGV
     HAAGRLDEFA HWAKSLTQRT ILRLLDPSIS AAGILRAEKI LDAVRDIVGP VAIEQLPIPY
     TAVATDLLAG KSVWFQRGPL DAAIRASIAI PGVIAPHEVD GRLLADGGIL DPLPMAPIAG
     VNADLTIAVS LNGSEAGPAR DAEPNVTAEW LNRMVRSTSA LFDVSAARSL LDRPTARAVL
     SRFGAAAAES DSWSQAPEIE QRPAGPPADR EEAADTPGLP KMGSFEVMNR TIDIAQSALA
     RHTLAGYPAD LLIEVPRSTC RSLEFHRAVE VIAVGRALAT QALEAFEIDD DESAAATIEG