Y107_HAEIN
ID Y107_HAEIN Reviewed; 420 AA.
AC Q57017; P96330;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 15-DEC-1998, sequence version 2.
DT 25-MAY-2022, entry version 138.
DE RecName: Full=UPF0053 protein HI_0107;
GN OrderedLocusNames=HI_0107;
OS Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae; Haemophilus.
OX NCBI_TaxID=71421;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX PubMed=7542800; DOI=10.1126/science.7542800;
RA Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT Rd.";
RL Science 269:496-512(1995).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the UPF0053 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAC21785.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; L42023; AAC21785.1; ALT_INIT; Genomic_DNA.
DR PIR; H64142; H64142.
DR RefSeq; NP_438281.1; NC_000907.1.
DR RefSeq; WP_032828395.1; NC_000907.1.
DR PDB; 3LAE; X-ray; 1.45 A; A=343-420.
DR PDBsum; 3LAE; -.
DR AlphaFoldDB; Q57017; -.
DR SMR; Q57017; -.
DR STRING; 71421.HI_0107; -.
DR EnsemblBacteria; AAC21785; AAC21785; HI_0107.
DR KEGG; hin:HI_0107; -.
DR PATRIC; fig|71421.8.peg.111; -.
DR eggNOG; COG4536; Bacteria.
DR HOGENOM; CLU_015237_4_1_6; -.
DR PhylomeDB; Q57017; -.
DR EvolutionaryTrace; Q57017; -.
DR Proteomes; UP000000579; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR CDD; cd04590; CBS_pair_CorC_HlyC_assoc; 1.
DR Gene3D; 3.10.580.10; -; 1.
DR Gene3D; 3.30.465.10; -; 1.
DR InterPro; IPR000644; CBS_dom.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR002550; CNNM.
DR InterPro; IPR036318; FAD-bd_PCMH-like_sf.
DR InterPro; IPR016169; FAD-bd_PCMH_sub2.
DR InterPro; IPR044751; Ion_transp-like_CBS.
DR InterPro; IPR005170; Transptr-assoc_dom.
DR Pfam; PF00571; CBS; 1.
DR Pfam; PF03471; CorC_HlyC; 1.
DR Pfam; PF01595; DUF21; 1.
DR SMART; SM01091; CorC_HlyC; 1.
DR SUPFAM; SSF54631; SSF54631; 1.
DR SUPFAM; SSF56176; SSF56176; 1.
DR PROSITE; PS51371; CBS; 2.
DR PROSITE; PS51846; CNNM; 1.
PE 1: Evidence at protein level;
KW 3D-structure; CBS domain; Cell membrane; Membrane; Reference proteome;
KW Repeat; Transmembrane; Transmembrane helix.
FT CHAIN 1..420
FT /note="UPF0053 protein HI_0107"
FT /id="PRO_0000088358"
FT TRANSMEM 3..23
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 65..85
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 92..112
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 126..146
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 2..190
FT /note="CNNM transmembrane"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01193"
FT DOMAIN 208..268
FT /note="CBS 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00703"
FT DOMAIN 273..333
FT /note="CBS 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00703"
FT STRAND 350..353
FT /evidence="ECO:0007829|PDB:3LAE"
FT HELIX 358..365
FT /evidence="ECO:0007829|PDB:3LAE"
FT HELIX 377..384
FT /evidence="ECO:0007829|PDB:3LAE"
FT STRAND 394..397
FT /evidence="ECO:0007829|PDB:3LAE"
FT STRAND 400..408
FT /evidence="ECO:0007829|PDB:3LAE"
FT STRAND 411..419
FT /evidence="ECO:0007829|PDB:3LAE"
SQ SEQUENCE 420 AA; 46960 MW; 7CFFD76A12937231 CRC64;
MDSIPLSTLF IILIICLVLS AYFSGSETGL LSLNKYRLRF LSEQGNKGAK KAEKLLEKPD
TLLSFILIFN NLVNISASAI ATVIGMRLYG DAGVAIATGL LTFVMLVFSE IFPKTVAAMH
AEKVSFFSSH ILTSLLKIFY PLVWLMNIFT KSLMQIVGLK LDMQKQVISS EELRSIVSEA
GEATPNEQHP QMLLSILDME TVTVDDIMVP RNEIGGINID DDWRAIMRQL NHAAHNRVVL
YKGSLDEQVL GILRVREAFR LLLEKNEFTK ETLIRAADEV YFIPESTPLK TQLANFRTNK
ERIGLVVDEY GDIKGLVTLE DILEEIVGDF TTSTAPSIDK EVIQQSDGSM IIDGSANLRD
LNKMFNWELD TEDARTFNGL ILEHLEEIPD EGTICEIDGL LITILEVGDN MIKQAKVVKL
