ID   Y107_METJA              Reviewed;         525 AA.
AC   Q57571;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 116.
DE   RecName: Full=Uncharacterized protein MJ0107;
GN   OrderedLocusNames=MJ0107;
OS   Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM
OS   10045 / NBRC 100440) (Methanococcus jannaschii).
OC   Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC   Methanocaldococcaceae; Methanocaldococcus.
OX   NCBI_TaxID=243232;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440;
RX   PubMed=8688087; DOI=10.1126/science.273.5278.1058;
RA   Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D., Sutton G.G.,
RA   Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D., Kerlavage A.R.,
RA   Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I., Overbeek R.,
RA   Kirkness E.F., Weinstock K.G., Merrick J.M., Glodek A., Scott J.L.,
RA   Geoghagen N.S.M., Weidman J.F., Fuhrmann J.L., Nguyen D., Utterback T.R.,
RA   Kelley J.M., Peterson J.D., Sadow P.W., Hanna M.C., Cotton M.D.,
RA   Roberts K.M., Hurst M.A., Kaine B.P., Borodovsky M., Klenk H.-P.,
RA   Fraser C.M., Smith H.O., Woese C.R., Venter J.C.;
RT   "Complete genome sequence of the methanogenic archaeon, Methanococcus
RT   jannaschii.";
RL   Science 273:1058-1073(1996).
RN   [2]
RP   LACK OF DHPS ACTIVITY.
RC   STRAIN=ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440;
RX   PubMed=10426953; DOI=10.1038/11525;
RA   Xu H., Aurora R., Rose G.D., White R.H.;
RT   "Identifying two ancient enzymes in Archaea using predicted secondary
RT   structure alignment.";
RL   Nat. Struct. Biol. 6:750-754(1999).
CC   -!- FUNCTION: Unknown. Does not possess dihydropteroate synthase (DHPS)
CC       activity since it does not catalyze the condensation of 6-
CC       hydroxymethyl-7,8-dihydropterin pyrophosphate (DHPP) and 4-
CC       aminobenzoate to form 7,8-dihydropteroate.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
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DR   EMBL; L77117; AAB98089.1; -; Genomic_DNA.
DR   PIR; C64313; C64313.
DR   AlphaFoldDB; Q57571; -.
DR   SMR; Q57571; -.
DR   STRING; 243232.MJ_0107; -.
DR   EnsemblBacteria; AAB98089; AAB98089; MJ_0107.
DR   KEGG; mja:MJ_0107; -.
DR   eggNOG; arCOG01978; Archaea.
DR   HOGENOM; CLU_041129_0_0_2; -.
DR   InParanoid; Q57571; -.
DR   OMA; DMIDLGM; -.
DR   PhylomeDB; Q57571; -.
DR   Proteomes; UP000000805; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004150; F:dihydroneopterin aldolase activity; IBA:GO_Central.
DR   GO; GO:0016740; F:transferase activity; IEA:UniProt.
DR   GO; GO:0006760; P:folic acid-containing compound metabolic process; IEA:InterPro.
DR   Gene3D; 3.20.20.20; -; 1.
DR   InterPro; IPR006156; Dihydroneopterin_aldolase.
DR   InterPro; IPR005236; Dihydropt_synth.
DR   InterPro; IPR011005; Dihydropteroate_synth-like.
DR   InterPro; IPR025595; DUF4346.
DR   InterPro; IPR045406; DUF6513.
DR   InterPro; IPR000489; Pterin-binding_dom.
DR   PANTHER; PTHR42844; PTHR42844; 1.
DR   Pfam; PF14251; DUF4346; 1.
DR   Pfam; PF20123; DUF6513; 1.
DR   Pfam; PF00809; Pterin_bind; 1.
DR   SUPFAM; SSF51717; SSF51717; 1.
DR   TIGRFAMs; TIGR00284; TIGR00284; 1.
DR   PROSITE; PS50972; PTERIN_BINDING; 1.
PE   4: Predicted;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..525
FT                   /note="Uncharacterized protein MJ0107"
FT                   /id="PRO_0000106696"
FT   TRANSMEM        28..48
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        353..373
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          146..394
FT                   /note="Pterin-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00334"
SQ   SEQUENCE   525 AA;  59645 MW;  AA8BA61C6B81863D CRC64;
     MREIMKILII TGKLAERKVK DAVKKYDFID VHVANISVAA FLTPNLIIKE IKKLENKLGK
     KLKDIYDFVL VTGLIRHDLK NVEEETGIKC FKSTREASDI PILIENLDKI KLSTKEYADL
     QLLEIIRKKC EEEIKKAEEQ ELGEGDIKIG KLKVGDKFPM RVLGEIVHAP WLKEKELEEK
     IIYYLESGAD MIDLGMVSNE NNADKIKDML KIARDLTDNP ISVDTLNTKE LIEAINLGAD
     MILSVDAGNL DELIPYLKDS ETAVVVLPTN YKTNYVPETI EGKIKSLEEN IKKLIDAGIE
     KIVADPILEP INNAGCSFIE SVIACREFKK RNKLPLFFGV GNVTELFDAD SNGVNALLAA
     IGAEIGANIL FTPEASAKCK FSIKELKIAS KMMFLAKKRN SLPKDIGYNL INYKDKRFEE
     EITFNSYNIP IIKAEEDERQ ILDEGSFKIE IDRKNKEIVA IYFNKRREPV LIIRGKKPKE
     IYETAIRLNL IKKLDHASYF GRELAKAEIA LRIGKKYNQD FDLFL