ID   Y1081_THEMA             Reviewed;         113 AA.
AC   Q9X0H0;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 1.
DT   25-MAY-2022, entry version 117.
DE   RecName: Full=Putative anti-sigma factor antagonist TM_1081;
GN   OrderedLocusNames=TM_1081;
OS   Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826
OS   / MSB8).
OC   Bacteria; Thermotogae; Thermotogales; Thermotogaceae; Thermotoga.
OX   NCBI_TaxID=243274;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8;
RX   PubMed=10360571; DOI=10.1038/20601;
RA   Nelson K.E., Clayton R.A., Gill S.R., Gwinn M.L., Dodson R.J., Haft D.H.,
RA   Hickey E.K., Peterson J.D., Nelson W.C., Ketchum K.A., McDonald L.A.,
RA   Utterback T.R., Malek J.A., Linher K.D., Garrett M.M., Stewart A.M.,
RA   Cotton M.D., Pratt M.S., Phillips C.A., Richardson D.L., Heidelberg J.F.,
RA   Sutton G.G., Fleischmann R.D., Eisen J.A., White O., Salzberg S.L.,
RA   Smith H.O., Venter J.C., Fraser C.M.;
RT   "Evidence for lateral gene transfer between Archaea and Bacteria from
RT   genome sequence of Thermotoga maritima.";
RL   Nature 399:323-329(1999).
CC   -!- FUNCTION: In the phosphorylated form it could act as an anti-anti-sigma
CC       factor that counteracts an anti-sigma factor and thus releases a sigma
CC       factor from inhibition. {ECO:0000250}.
CC   -!- PTM: Phosphorylated on a serine residue. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the anti-sigma-factor antagonist family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE000512; AAD36158.1; -; Genomic_DNA.
DR   PIR; A72297; A72297.
DR   RefSeq; NP_228887.1; NC_000853.1.
DR   RefSeq; WP_004080402.1; NZ_CP011107.1.
DR   PDB; 2KA5; NMR; -; A=1-113.
DR   PDB; 3F43; X-ray; 1.59 A; A=1-113.
DR   PDBsum; 2KA5; -.
DR   PDBsum; 3F43; -.
DR   AlphaFoldDB; Q9X0H0; -.
DR   BMRB; Q9X0H0; -.
DR   SMR; Q9X0H0; -.
DR   STRING; 243274.THEMA_08950; -.
DR   EnsemblBacteria; AAD36158; AAD36158; TM_1081.
DR   KEGG; tma:TM1081; -.
DR   eggNOG; COG1366; Bacteria.
DR   InParanoid; Q9X0H0; -.
DR   OMA; VVILMPN; -.
DR   OrthoDB; 1864829at2; -.
DR   EvolutionaryTrace; Q9X0H0; -.
DR   Proteomes; UP000008183; Chromosome.
DR   GO; GO:0043856; F:anti-sigma factor antagonist activity; IBA:GO_Central.
DR   Gene3D; 3.30.750.24; -; 1.
DR   InterPro; IPR003658; Anti-sigma_ant.
DR   InterPro; IPR002645; STAS_dom.
DR   InterPro; IPR036513; STAS_dom_sf.
DR   Pfam; PF01740; STAS; 1.
DR   SUPFAM; SSF52091; SSF52091; 1.
DR   TIGRFAMs; TIGR00377; ant_ant_sig; 1.
DR   PROSITE; PS50801; STAS; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Phosphoprotein; Reference proteome.
FT   CHAIN           1..113
FT                   /note="Putative anti-sigma factor antagonist TM_1081"
FT                   /id="PRO_0000194206"
FT   DOMAIN          1..110
FT                   /note="STAS"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00198"
FT   MOD_RES         55
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250"
FT   STRAND          4..7
FT                   /evidence="ECO:0007829|PDB:3F43"
FT   STRAND          10..13
FT                   /evidence="ECO:0007829|PDB:3F43"
FT   TURN            21..23
FT                   /evidence="ECO:0007829|PDB:3F43"
FT   HELIX           24..34
FT                   /evidence="ECO:0007829|PDB:3F43"
FT   HELIX           36..38
FT                   /evidence="ECO:0007829|PDB:3F43"
FT   STRAND          42..46
FT                   /evidence="ECO:0007829|PDB:3F43"
FT   HELIX           55..71
FT                   /evidence="ECO:0007829|PDB:3F43"
FT   STRAND          74..78
FT                   /evidence="ECO:0007829|PDB:3F43"
FT   HELIX           82..90
FT                   /evidence="ECO:0007829|PDB:3F43"
FT   HELIX           93..95
FT                   /evidence="ECO:0007829|PDB:3F43"
FT   STRAND          97..102
FT                   /evidence="ECO:0007829|PDB:3F43"
FT   HELIX           103..111
FT                   /evidence="ECO:0007829|PDB:3F43"
SQ   SEQUENCE   113 AA;  12973 MW;  88603AF80637DA4E CRC64;
     MFPYKIVDDV VILMPNKELN IENAHLFKKW VFDEFLNKGY NKIFLVLSDV ESIDSFSLGV
     IVNILKSISS SGGFFALVSP NEKVERVLSL TNLDRIVKIY DTISEAMEEV RRK