ID   Y1085_MYCTU             Reviewed;         242 AA.
AC   P9WFN7; L0T5S7; O53433; P67157;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 32.
DE   RecName: Full=UPF0073 membrane protein Rv1085c;
GN   OrderedLocusNames=Rv1085c; ORFNames=MTV017.38c;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the UPF0073 (Hly-III) family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AL123456; CCP43836.1; -; Genomic_DNA.
DR   PIR; C70895; C70895.
DR   RefSeq; NP_215601.1; NC_000962.3.
DR   RefSeq; WP_003901993.1; NZ_NVQJ01000080.1.
DR   AlphaFoldDB; P9WFN7; -.
DR   SMR; P9WFN7; -.
DR   STRING; 83332.Rv1085c; -.
DR   PaxDb; P9WFN7; -.
DR   DNASU; 887107; -.
DR   GeneID; 45425058; -.
DR   GeneID; 887107; -.
DR   KEGG; mtu:Rv1085c; -.
DR   TubercuList; Rv1085c; -.
DR   eggNOG; COG1272; Bacteria.
DR   OMA; HEVFHSL; -.
DR   PhylomeDB; P9WFN7; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0019835; P:cytolysis; IEA:InterPro.
DR   InterPro; IPR004254; AdipoR/HlyIII-related.
DR   InterPro; IPR005744; Hy-lIII.
DR   PANTHER; PTHR20855; PTHR20855; 1.
DR   Pfam; PF03006; HlyIII; 1.
DR   TIGRFAMs; TIGR01065; hlyIII; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..242
FT                   /note="UPF0073 membrane protein Rv1085c"
FT                   /id="PRO_0000176902"
FT   TRANSMEM        42..62
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        67..87
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        108..128
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        133..153
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        159..179
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        186..206
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        222..242
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   242 AA;  26034 MW;  BBC1DE12CF8D3500 CRC64;
     MSGQADTATT AEARTPAHAA HHLVEGVARV LTKPRFRGWI HVYSAGTAVL AGASLVAVSW
     AVGSAKAGLT TLAYTAATIT MFTVSATYHR VNWKSATARN WMKRADHSMI FVFIAGSYTP
     FALLALPAHD GRVVLSIVWG GAIAGILLKM CWPAAPRSVG VPLYLLLGWV AVWYTATILH
     NAGVTALVLL FVGGALYSIG GILYAVRWPD PWPTTFGYHE FFHACTAVAA ICHYIAMWFV
     VF