ID   Y1085_PICTO             Reviewed;         573 AA.
AC   Q6L032;
DT   16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 91.
DE   RecName: Full=Putative adenine deaminase PTO1085;
DE            Short=Adenase;
DE            Short=Adenine aminase;
DE            EC=3.5.4.2;
GN   OrderedLocusNames=PTO1085;
OS   Picrophilus torridus (strain ATCC 700027 / DSM 9790 / JCM 10055 / NBRC
OS   100828).
OC   Archaea; Candidatus Thermoplasmatota; Thermoplasmata; Thermoplasmatales;
OC   Picrophilaceae; Picrophilus.
OX   NCBI_TaxID=263820;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828;
RX   PubMed=15184674; DOI=10.1073/pnas.0401356101;
RA   Fuetterer O., Angelov A., Liesegang H., Gottschalk G., Schleper C.,
RA   Schepers B., Dock C., Antranikian G., Liebl W.;
RT   "Genome sequence of Picrophilus torridus and its implications for life
RT   around pH 0.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:9091-9096(2004).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=adenine + H(+) + H2O = hypoxanthine + NH4(+);
CC         Xref=Rhea:RHEA:23688, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16708, ChEBI:CHEBI:17368, ChEBI:CHEBI:28938; EC=3.5.4.2;
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       Adenine deaminase family. {ECO:0000305}.
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DR   EMBL; AE017261; AAT43670.1; -; Genomic_DNA.
DR   RefSeq; WP_011177886.1; NC_005877.1.
DR   AlphaFoldDB; Q6L032; -.
DR   SMR; Q6L032; -.
DR   STRING; 263820.PTO1085; -.
DR   EnsemblBacteria; AAT43670; AAT43670; PTO1085.
DR   GeneID; 2844592; -.
DR   KEGG; pto:PTO1085; -.
DR   PATRIC; fig|263820.9.peg.1125; -.
DR   eggNOG; arCOG00693; Archaea.
DR   HOGENOM; CLU_027935_0_0_2; -.
DR   OrthoDB; 12286at2157; -.
DR   Proteomes; UP000000438; Chromosome.
DR   GO; GO:0000034; F:adenine deaminase activity; IEA:UniProtKB-EC.
DR   Gene3D; 2.30.40.10; -; 1.
DR   InterPro; IPR026912; Adenine_deam_C.
DR   InterPro; IPR006680; Amidohydro-rel.
DR   InterPro; IPR011059; Metal-dep_hydrolase_composite.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   Pfam; PF13382; Adenine_deam_C; 1.
DR   Pfam; PF01979; Amidohydro_1; 1.
DR   SUPFAM; SSF51338; SSF51338; 1.
DR   SUPFAM; SSF51556; SSF51556; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Reference proteome.
FT   CHAIN           1..573
FT                   /note="Putative adenine deaminase PTO1085"
FT                   /id="PRO_0000142449"
SQ   SEQUENCE   573 AA;  65635 MW;  14ABA093C2F7D892 CRC64;
     MLLKNIKISN DYNIFMIIAS RKPSLKDIYK IIKVSKFDEP ADLIIEDASY IDIYTKRISS
     GNIAIASGRI AYIGDEMPLK NNDTRIIKND FLIAPGYIEG HAHPFQIYNP VTFNEIMIRH
     GTSMVISDDL PIYIKMGLKN IKRFMRFMGR LPVKNFWSVR LDSQSMIDME KFSYIKIKEL
     LNDDYVLQAG EITGWPYIIN MEKNMLKNIY NSQFLGKRIE THNPGASKNT LNRMAAAGIT
     SDHEAITGED VKTRLSLGYH VFLRYSSIRK DLKDELKYII DEKLPLNRLM LTNDGSPYYN
     DYMGMDDLIK IAISTGLNPF DAYSMASLNP AVYYNIDGIY GGIAPGRLAD MNFIRDLYNP
     EPVFLMLDGK IIDKEVKLDP PDWKGYGMLY KNRNIDINKI NFNGSDETLF MRNQVIMDLN
     KYKMEDSMEI HLITKDLKRI VSSNIHGMGQ FDALASSYNI EGSYIVIGSS HDLMKKALKE
     VIKNGGIVFN GNKNIRIELK ILGIMSDKHS DDVRNITEEF RSTMRGSGYK FDDPVYSMLF
     LNSINLPYYR ITSSGIVEVK TRKIIKKPVS LKI