ID   Y1092_METJA             Reviewed;         214 AA.
AC   Q58492;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 109.
DE   RecName: Full=Putative nickel/cobalt efflux system MJ1092;
GN   OrderedLocusNames=MJ1092;
OS   Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM
OS   10045 / NBRC 100440) (Methanococcus jannaschii).
OC   Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC   Methanocaldococcaceae; Methanocaldococcus.
OX   NCBI_TaxID=243232;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440;
RX   PubMed=8688087; DOI=10.1126/science.273.5278.1058;
RA   Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D., Sutton G.G.,
RA   Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D., Kerlavage A.R.,
RA   Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I., Overbeek R.,
RA   Kirkness E.F., Weinstock K.G., Merrick J.M., Glodek A., Scott J.L.,
RA   Geoghagen N.S.M., Weidman J.F., Fuhrmann J.L., Nguyen D., Utterback T.R.,
RA   Kelley J.M., Peterson J.D., Sadow P.W., Hanna M.C., Cotton M.D.,
RA   Roberts K.M., Hurst M.A., Kaine B.P., Borodovsky M., Klenk H.-P.,
RA   Fraser C.M., Smith H.O., Woese C.R., Venter J.C.;
RT   "Complete genome sequence of the methanogenic archaeon, Methanococcus
RT   jannaschii.";
RL   Science 273:1058-1073(1996).
CC   -!- FUNCTION: Efflux system for nickel and cobalt. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the NiCoT transporter (TC 2.A.52) family.
CC       {ECO:0000305}.
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DR   EMBL; L77117; AAB99093.1; -; Genomic_DNA.
DR   PIR; C64436; C64436.
DR   RefSeq; WP_010870604.1; NC_000909.1.
DR   AlphaFoldDB; Q58492; -.
DR   STRING; 243232.MJ_1092; -.
DR   TCDB; 2.A.113.1.4; the nickel/cobalt transporter (nico) family.
DR   EnsemblBacteria; AAB99093; AAB99093; MJ_1092.
DR   GeneID; 1451988; -.
DR   KEGG; mja:MJ_1092; -.
DR   eggNOG; arCOG03918; Archaea.
DR   HOGENOM; CLU_058605_4_1_2; -.
DR   InParanoid; Q58492; -.
DR   OMA; HALEPGH; -.
DR   OrthoDB; 93540at2157; -.
DR   Proteomes; UP000000805; Chromosome.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:InterPro.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0046583; F:cation efflux transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0015099; F:nickel cation transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0006824; P:cobalt ion transport; IEA:UniProtKB-KW.
DR   GO; GO:0035784; P:nickel cation homeostasis; IBA:GO_Central.
DR   GO; GO:0032025; P:response to cobalt ion; IBA:GO_Central.
DR   GO; GO:0010045; P:response to nickel cation; IBA:GO_Central.
DR   InterPro; IPR011541; Ni/Co_transpt_high_affinity.
DR   Pfam; PF03824; NicO; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Cobalt; Cobalt transport; Ion transport; Membrane; Nickel;
KW   Nickel transport; Reference proteome; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..214
FT                   /note="Putative nickel/cobalt efflux system MJ1092"
FT                   /id="PRO_0000194015"
FT   TRANSMEM        2..22
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        46..66
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        79..99
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        116..136
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        149..169
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        188..208
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   214 AA;  22704 MW;  A21A318891B7891B CRC64;
     MVMIMELLYA ITAFILGMLH ALEPGHGKSV VAAYILGTKA DLKDAILLGT TITISHTAVI
     FLLGILSIYL LESLNVDVVH DMMSVVGGLI LIAVGIWIIR SYLHPHEHKV DTKKGVITLG
     LSAGLVPCPA ALAVLLLSIS SGNLIDGLIY VAIFSIGLAI SLTGLAVAFV ESKELIKKYV
     GNRKVSKLPL ISGSIIILIG LYTIAHPILE HAIV