Y1104_HAEIN
ID Y1104_HAEIN Reviewed; 407 AA.
AC P71369;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1997, sequence version 1.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=Putative metabolite transport protein HI_1104;
GN OrderedLocusNames=HI_1104;
OS Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae; Haemophilus.
OX NCBI_TaxID=71421;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX PubMed=7542800; DOI=10.1126/science.7542800;
RA Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT Rd.";
RL Science 269:496-512(1995).
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass
CC membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. Aromatic
CC acid:H(+) symporter (AAHS) (TC 2.A.1.15) family. {ECO:0000305}.
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DR EMBL; L42023; AAC22759.1; -; Genomic_DNA.
DR PIR; C64167; C64167.
DR RefSeq; NP_439261.1; NC_000907.1.
DR RefSeq; WP_005693428.1; NC_000907.1.
DR AlphaFoldDB; P71369; -.
DR SMR; P71369; -.
DR STRING; 71421.HI_1104; -.
DR EnsemblBacteria; AAC22759; AAC22759; HI_1104.
DR KEGG; hin:HI_1104; -.
DR PATRIC; fig|71421.8.peg.1152; -.
DR eggNOG; COG2814; Bacteria.
DR HOGENOM; CLU_001265_46_6_6; -.
DR OMA; LATWVPT; -.
DR PhylomeDB; P71369; -.
DR BioCyc; HINF71421:G1GJ1-1139-MON; -.
DR Proteomes; UP000000579; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0046943; F:carboxylic acid transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0046942; P:carboxylic acid transport; IBA:GO_Central.
DR Gene3D; 1.20.1250.20; -; 2.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR005829; Sugar_transporter_CS.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR PROSITE; PS50850; MFS; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..407
FT /note="Putative metabolite transport protein HI_1104"
FT /id="PRO_0000050490"
FT TOPO_DOM 1..16
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 17..37
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 38..48
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 49..69
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 70..77
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 78..98
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 99..107
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 108..128
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 129..138
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 139..159
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 160
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 161..181
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 182..224
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 225..245
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 246..261
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 262..282
FT /note="Helical; Name=8"
FT /evidence="ECO:0000255"
FT TOPO_DOM 283..288
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 289..309
FT /note="Helical; Name=9"
FT /evidence="ECO:0000255"
FT TOPO_DOM 310..312
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 313..333
FT /note="Helical; Name=10"
FT /evidence="ECO:0000255"
FT TOPO_DOM 334..357
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 358..378
FT /note="Helical; Name=11"
FT /evidence="ECO:0000255"
FT TRANSMEM 379..399
FT /note="Helical; Name=12"
FT /evidence="ECO:0000255"
FT TOPO_DOM 400..407
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
SQ SEQUENCE 407 AA; 43682 MW; 618588C6CB37C4A9 CRC64;
MTNKVNSYGW KALIGSAVGY GMDGFDLLIL GFMLSAISAD LNLTPAQGGS LVTWTLIGAV
FGGILFGALS DKYGRVRVLT WTILLFAVFT GLCAIAQGYW DLLIYRTIAG IGLGGEFGIG
MALAAEAWPA RHRAKAASYV ALGWQVGVLG AALLTPLLLP HIGWRGMFLV GIFPAFVAWF
LRSHLHEPEI FTQKQTALST QSSFTDKLRS FQLLIKDKAT SKISLGIVVL TSVQNFGYYG
IMIWLPNFLS KQLGFSLTKS GLWTAVTVCG MMAGIWIFGQ LADRIGRKPS FLLFQLGAVI
SIVVYSQLTD PDIMLLAGAF LGMFVNGMLG GYGALMAEAY PTEARATAQN VLFNIGRAVG
GFGPVVVGSV VLAYSFQTAI ALLAIIYVID MLATIFLIPE LKGKALD
