ID   Y1107_HAEIN             Reviewed;         468 AA.
AC   Q57007; P96339;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 112.
DE   RecName: Full=Uncharacterized Na(+)/H(+) antiporter HI_1107;
GN   OrderedLocusNames=HI_1107;
OS   Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=71421;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=7542800; DOI=10.1126/science.7542800;
RA   Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA   Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA   McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA   Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA   Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA   Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA   Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA   Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT   "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT   Rd.";
RL   Science 269:496-512(1995).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the NhaC Na(+)/H(+) (TC 2.A.35) antiporter
CC       family. {ECO:0000305}.
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DR   EMBL; L42023; AAC22762.1; -; Genomic_DNA.
DR   PIR; I64182; I64182.
DR   RefSeq; NP_439264.1; NC_000907.1.
DR   RefSeq; WP_010869131.1; NC_000907.1.
DR   AlphaFoldDB; Q57007; -.
DR   STRING; 71421.HI_1107; -.
DR   EnsemblBacteria; AAC22762; AAC22762; HI_1107.
DR   KEGG; hin:HI_1107; -.
DR   PATRIC; fig|71421.8.peg.1155; -.
DR   eggNOG; COG1757; Bacteria.
DR   HOGENOM; CLU_033405_1_1_6; -.
DR   OMA; NTCGAYQ; -.
DR   PhylomeDB; Q57007; -.
DR   BioCyc; HINF71421:G1GJ1-1142-MON; -.
DR   Proteomes; UP000000579; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR   GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR   InterPro; IPR004770; Na/H_antiport_NhaC.
DR   InterPro; IPR018461; Na/H_Antiport_NhaC-like_C.
DR   Pfam; PF03553; Na_H_antiporter; 1.
DR   TIGRFAMs; TIGR00931; antiport_nhaC; 1.
PE   3: Inferred from homology;
KW   Antiport; Cell membrane; Ion transport; Membrane; Reference proteome;
KW   Sodium; Sodium transport; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..468
FT                   /note="Uncharacterized Na(+)/H(+) antiporter HI_1107"
FT                   /id="PRO_0000052418"
FT   TRANSMEM        13..33
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        40..60
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        76..96
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        112..132
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        141..161
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        194..214
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        237..257
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        260..280
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        328..348
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        354..374
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        414..434
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        443..463
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   468 AA;  49890 MW;  4213BC32C7F13F27 CRC64;
     MKTTHRTRMP TTLEAFSPII VMLLLLGLGY ALFDLPAEPL MIISTVFAGF LVFKLGHCYL
     DILDAISEKI AKTMPALLIL ITVGLLIGTW ISGGTIPMMI YYGLKAISPE YLYVTALFLT
     AIVSICTGTS WGSAGTVGVA FMGVAIGLDA NLAATAGAVV AGAYFGDKLS PLSDTTNIAS
     AAAGVDLYEH IAHLLYTTLP SFILSATVYV VYGLNYDFSN VATPEKVNTM IHELEQVYHF
     NFLLLIPVAI VLWGSITKKP TIPVMLLSAF IAIINAILIQ KFSLSDVINS AVNGFDTSMI
     HHTSVSSDLS RLLNRGGMNS MMGTLLICFC ALSFAGVLQL SGALTVIIQK LLTFVHSTLS
     LIITTILCGL TMIGVTCNGQ ISILIPGEML KNAYVEKGLH PKNLSRTAED SATIIEPILP
     WTAAGAYMAG TLGVATLSYL PWAILCWSGI IFAIIYGASG IGIAKLKK