Y1121_CITRI
ID Y1121_CITRI Reviewed; 1593 AA.
AC D2TV88;
DT 11-JUL-2012, integrated into UniProtKB/Swiss-Prot.
DT 02-MAR-2010, sequence version 1.
DT 03-AUG-2022, entry version 71.
DE RecName: Full=Probable autotransporter ROD_p1121;
DE Short=P1121;
DE Flags: Precursor;
GN OrderedLocusNames=ROD_p1121;
OS Citrobacter rodentium (strain ICC168) (Citrobacter freundii biotype 4280).
OG Plasmid pCROD1.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Citrobacter.
OX NCBI_TaxID=637910;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ICC168;
RX PubMed=19897651; DOI=10.1128/jb.01144-09;
RA Petty N.K., Bulgin R., Crepin V.F., Cerdeno-Tarraga A.M., Schroeder G.N.,
RA Quail M.A., Lennard N., Corton C., Barron A., Clark L., Toribio A.L.,
RA Parkhill J., Dougan G., Frankel G., Thomson N.R.;
RT "The Citrobacter rodentium genome sequence reveals convergent evolution
RT with human pathogenic Escherichia coli.";
RL J. Bacteriol. 192:525-538(2010).
RN [2]
RP PROTEIN SEQUENCE OF 826-849; 1135-1188; 1248-1288; 1293-1316; 1328-1335;
RP 1343-1390; 1430-1470; 1480-1488 AND 1536-1552, AND SUBCELLULAR LOCATION.
RC STRAIN=ICC169;
RX PubMed=22466966; DOI=10.1038/nsmb.2261;
RA Selkrig J., Mosbahi K., Webb C.T., Belousoff M.J., Perry A.J., Wells T.J.,
RA Morris F., Leyton D.L., Totsika M., Phan M.D., Celik N., Kelly M.,
RA Oates C., Hartland E.L., Robins-Browne R.M., Ramarathinam S.H.,
RA Purcell A.W., Schembri M.A., Strugnell R.A., Henderson I.R., Walker D.,
RA Lithgow T.;
RT "Discovery of an archetypal protein transport system in bacterial outer
RT membranes.";
RL Nat. Struct. Mol. Biol. 19:506-510(2012).
CC -!- FUNCTION: A putative autotransporter. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell outer membrane
CC {ECO:0000269|PubMed:22466966}. Note=The N-terminus is on the cell
CC surface as it is accessible to trypsin.
CC -!- DOMAIN: The signal peptide, cleaved at the inner membrane, guides the
CC autotransporter protein to the periplasmic space. Insertion of the C-
CC terminal translocator domain in the outer membrane forms a hydrophilic
CC pore for translocation of the passenger domain to the bacterial cell
CC surface, with subsequent cleavage. Finally, the mature protein remains
CC tightly associated with the bacterium (Probable). {ECO:0000305}.
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DR EMBL; FN543503; CBG91774.1; -; Genomic_DNA.
DR RefSeq; WP_012908908.1; NC_013717.1.
DR AlphaFoldDB; D2TV88; -.
DR SMR; D2TV88; -.
DR KEGG; cro:ROD_p1121; -.
DR HOGENOM; CLU_004643_1_0_6; -.
DR OMA; DITQNSG; -.
DR OrthoDB; 1713183at2; -.
DR PHI-base; PHI:5299; -.
DR Proteomes; UP000001889; Plasmid pCROD1.
DR GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR Gene3D; 2.160.20.20; -; 5.
DR Gene3D; 2.40.128.130; -; 1.
DR InterPro; IPR030930; AIDA.
DR InterPro; IPR005546; Autotransporte_beta.
DR InterPro; IPR036709; Autotransporte_beta_dom_sf.
DR InterPro; IPR012332; Autotransporter_pectin_lyase_C.
DR InterPro; IPR024973; ESPR.
DR InterPro; IPR006315; OM_autotransptr_brl.
DR InterPro; IPR011050; Pectin_lyase_fold/virulence.
DR InterPro; IPR004899; Pertactin_central.
DR InterPro; IPR003991; Pertactin_virulence_factor.
DR Pfam; PF16168; AIDA; 10.
DR Pfam; PF03797; Autotransporter; 1.
DR Pfam; PF13018; ESPR; 1.
DR Pfam; PF03212; Pertactin; 1.
DR PRINTS; PR01484; PRTACTNFAMLY.
DR SMART; SM00869; Autotransporter; 1.
DR SUPFAM; SSF103515; SSF103515; 1.
DR SUPFAM; SSF51126; SSF51126; 2.
DR TIGRFAMs; TIGR01414; autotrans_barl; 1.
DR TIGRFAMs; TIGR04415; O_hepto_targRPT; 20.
DR PROSITE; PS51208; AUTOTRANSPORTER; 1.
PE 1: Evidence at protein level;
KW Cell outer membrane; Direct protein sequencing; Membrane; Plasmid;
KW Reference proteome; Signal; Transmembrane; Transmembrane beta strand.
FT SIGNAL 1..54
FT /evidence="ECO:0000255"
FT CHAIN 55..1593
FT /note="Probable autotransporter ROD_p1121"
FT /id="PRO_0000418091"
FT DOMAIN 1325..1593
FT /note="Autotransporter"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00556"
FT REGION 65..100
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1267..1286
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1593 AA; 160073 MW; D798BEE5D7520E11 CRC64;
MNKVYNTVWN ESTGMWVVTS ELTRKGGRRP RQIRRTALAG LIAGLLLPSA PALAVDYNNE
TLGSGATSSS MSLNAGDTAT DTTINSGGSQ RVSSGGSATS TTINSGGFQY VSSGGSATDT
TINSGGYQHV SSGGSATDTT INSGGYLSVS GGGTAVDITQ NSGGVIDTNT YATLSGTNIN
GSFSIVNGSA SNMLLENGGF LSVLNGHQAT NTTINSGGYL SVYGDGSAVD ITQNSGGAIS
TDTSATLSGT NINGSFSIAG GSASNMLLEN RGQLNVNSGH QATNTIINSG GNQHISGGGS
ATDTTINSAG FQYVYSGGSA TSTTINRGGN QYVSGGSATN TTINSGGYLS VYGGGTAVDI
TQNSGGAIDT NTYATLSGTN INGSFSIAGG SASNMLLENG GYLNVNSGHQ ATNTTINSGG
GLRVSGGGTA VDITQNSGGA ISADTSATLS GTNINGSFSI ANGSASNMLL ENGGSLYVNS
GHQATNTTIN SGGGLRVSGG GTAVDITQNS GGAIDTNTYA TLSGTNINGS FSIANGSASN
MLLENGGYLY VDGGHQATNT TINSGGILSV SGGGTAVDIT QNSGGVIDTN TYATLSGTNI
NGSFSIANGS ASNMLLENGG FLYVNSGHQA MNTTINNSRS TMNVLGGGSA TSTTINSGGY
QYVSSGGSAT STTINSGGNQ YVSSGGSATD TTINSGGSLV VFDGTAVDIT QNSGGAITAD
TSATLSGTNI NGSFSIANGS ASNMLLERGS LYVEGGHQAT NTTINGGGSM DVSTDGSATN
TTINDGGQMY VSTDGSVTST IVNIGGFVNL LGGSATDTTL NEGGRMLVNP QGSATGTIIN
RGGYQEILRS AGAANTIING GQQSVLSGGS ATDTTLNSGG AQYINNGGSA TDTTLNSGGA
QYINNGGSVT NTTINSGGGQ YVYINGNVTK TTITDGGILQ VDAGGSASQV TQNSGGAIVT
NTSAVLSGTN DKGTFSIAGG SASNMSLENG GLLTVLVGHD ASDTTVGSDG TLSVQSGGVL
RGTTTLTDNG TLVGNMVTNE GNLYFLNNSA ATFAGTLTGT GTLTQEGGNT RFSGLLSQDG
GITLHSGAAM TMVTLQANAN VTTQSGTSLT LDNGSILTGN VTGDNTGAGD MTVKGASVWH
LDGDATVGAL TLDNGTVDFR PSATTRLTQA FRPVSLVSES LSGNGTFRMN TDIASHTGDM
LNVTGNANGN FVLDIRNTGL EPVSAGTPLQ VVHTGSGDAA FSLNGGKVDA GTWEYYLNKE
NTDWYLKADS SQPGTDNPGT DNPVPPVRHT TKSADAVLDM ATAPVYVFNS ELQSLRFRHG
DVMQNTRSPG GVWGRYTGSD TRISGGAGSG YSLTQSGMET GGDTVFDLNE SRLAVGAFVS
YSDNSISHNR GGSSTVGSTG GGLYATWFNN DGYYVDGVIK VNRFRNELRT WMSDGTAVKG
DYHQNGFGGS LEAGRTFSLN ENTWIQPYLR STAFRAESKD ISLDNGMKAK AGTTKSLQGE
VGVNLGMNLD VAGTVVRPYL TTAVSHEFSD NNRVRINDSY NFTNDISGTT GKYGAGVSAQ
LTANAGVWAE ASYQNGENTE SPVTGSVGFR INF
