ID   Y1125_HAEI8             Reviewed;         221 AA.
AC   Q4QLV5;
DT   07-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT   07-FEB-2006, sequence version 2.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=UPF0758 protein NTHI1125;
GN   OrderedLocusNames=NTHI1125;
OS   Haemophilus influenzae (strain 86-028NP).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=281310;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=86-028NP;
RX   PubMed=15968074; DOI=10.1128/jb.187.13.4627-4636.2005;
RA   Harrison A., Dyer D.W., Gillaspy A., Ray W.C., Mungur R., Carson M.B.,
RA   Zhong H., Gipson J., Gipson M., Johnson L.S., Lewis L., Bakaletz L.O.,
RA   Munson R.S. Jr.;
RT   "Genomic sequence of an otitis media isolate of nontypeable Haemophilus
RT   influenzae: comparative study with H. influenzae serotype d, strain KW20.";
RL   J. Bacteriol. 187:4627-4636(2005).
CC   -!- SIMILARITY: Belongs to the UPF0758 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAX87992.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; CP000057; AAX87992.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_013526173.1; NC_007146.2.
DR   AlphaFoldDB; Q4QLV5; -.
DR   SMR; Q4QLV5; -.
DR   EnsemblBacteria; AAX87992; AAX87992; NTHI1125.
DR   KEGG; hit:NTHI1125; -.
DR   HOGENOM; CLU_073529_0_2_6; -.
DR   OrthoDB; 1833204at2; -.
DR   Proteomes; UP000002525; Chromosome.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd08071; MPN_DUF2466; 1.
DR   InterPro; IPR037518; MPN.
DR   InterPro; IPR025657; RadC_JAB.
DR   InterPro; IPR010994; RuvA_2-like.
DR   InterPro; IPR001405; UPF0758.
DR   InterPro; IPR020891; UPF0758_CS.
DR   PANTHER; PTHR30471; PTHR30471; 1.
DR   Pfam; PF04002; RadC; 1.
DR   SUPFAM; SSF47781; SSF47781; 1.
DR   TIGRFAMs; TIGR00608; radc; 1.
DR   PROSITE; PS50249; MPN; 1.
DR   PROSITE; PS01302; UPF0758; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Metal-binding; Metalloprotease; Protease; Zinc.
FT   CHAIN           1..221
FT                   /note="UPF0758 protein NTHI1125"
FT                   /id="PRO_0000190704"
FT   DOMAIN          98..221
FT                   /note="MPN"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01182"
FT   MOTIF           170..183
FT                   /note="JAMM motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01182"
FT   BINDING         170
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01182"
FT   BINDING         172
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01182"
FT   BINDING         183
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01182"
SQ   SEQUENCE   221 AA;  25057 MW;  C9A7AFED3BFB5602 CRC64;
     MENNDELMPR EKLLAFGAKA LSDYELLAIF LRTGIKDCPV MSLSKNVLTH FGSLHALLSA
     DKKAFCSVKG LGITQFIQLQ AITEMTKRYL KQEMLSTPII NDLETVKLFL LTELQHEERE
     VFMVLFLDNQ HRLIKKERLF LGTINVSAVY PREIIKEALY CNAAALILAH NHPSGITEPS
     YSDQLITKKI QDAAELMEIR VLDHLIVGKS DCYSFAENCL L