ID   Y1139_STRP1             Reviewed;          61 AA.
AC   P67532; Q48YU3; Q99ZP7;
DT   11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   25-MAY-2022, entry version 107.
DE   RecName: Full=Probable tautomerase SPy_1139/M5005_Spy0861;
DE            EC=5.3.2.-;
GN   OrderedLocusNames=SPy_1139, M5005_Spy0861;
OS   Streptococcus pyogenes serotype M1.
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=301447;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700294 / SF370 / Serotype M1;
RX   PubMed=11296296; DOI=10.1073/pnas.071559398;
RA   Ferretti J.J., McShan W.M., Ajdic D.J., Savic D.J., Savic G., Lyon K.,
RA   Primeaux C., Sezate S., Suvorov A.N., Kenton S., Lai H.S., Lin S.P.,
RA   Qian Y., Jia H.G., Najar F.Z., Ren Q., Zhu H., Song L., White J., Yuan X.,
RA   Clifton S.W., Roe B.A., McLaughlin R.E.;
RT   "Complete genome sequence of an M1 strain of Streptococcus pyogenes.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:4658-4663(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-947 / MGAS5005 / Serotype M1;
RX   PubMed=16088826; DOI=10.1086/432514;
RA   Sumby P., Porcella S.F., Madrigal A.G., Barbian K.D., Virtaneva K.,
RA   Ricklefs S.M., Sturdevant D.E., Graham M.R., Vuopio-Varkila J., Hoe N.P.,
RA   Musser J.M.;
RT   "Evolutionary origin and emergence of a highly successful clone of serotype
RT   M1 group A Streptococcus involved multiple horizontal gene transfer
RT   events.";
RL   J. Infect. Dis. 192:771-782(2005).
CC   -!- SIMILARITY: Belongs to the 4-oxalocrotonate tautomerase family.
CC       {ECO:0000305}.
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DR   EMBL; AE004092; AAK34011.1; -; Genomic_DNA.
DR   EMBL; CP000017; AAZ51479.1; -; Genomic_DNA.
DR   RefSeq; NP_269290.1; NC_002737.2.
DR   AlphaFoldDB; P67532; -.
DR   SMR; P67532; -.
DR   STRING; 1314.HKU360_00923; -.
DR   PaxDb; P67532; -.
DR   EnsemblBacteria; AAK34011; AAK34011; SPy_1139.
DR   KEGG; spy:SPy_1139; -.
DR   KEGG; spz:M5005_Spy0861; -.
DR   PATRIC; fig|160490.10.peg.992; -.
DR   HOGENOM; CLU_148073_5_1_9; -.
DR   OMA; HIMINDM; -.
DR   Proteomes; UP000000750; Chromosome.
DR   GO; GO:0016853; F:isomerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006725; P:cellular aromatic compound metabolic process; IEA:InterPro.
DR   Gene3D; 3.30.429.10; -; 1.
DR   InterPro; IPR004370; 4-oxalocrotonate_tautomerase.
DR   InterPro; IPR014347; Tautomerase/MIF_sf.
DR   Pfam; PF01361; Tautomerase; 1.
DR   SUPFAM; SSF55331; SSF55331; 1.
PE   3: Inferred from homology;
KW   Isomerase; Reference proteome.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250"
FT   CHAIN           2..61
FT                   /note="Probable tautomerase SPy_1139/M5005_Spy0861"
FT                   /id="PRO_0000209555"
FT   ACT_SITE        2
FT                   /note="Proton acceptor; via imino nitrogen"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   61 AA;  7055 MW;  689FE80C7CC05754 CRC64;
     MPFVTIDLFE GRSQEQKNQL AREVTEVVSR IAKAPKENIH VFINDMPEGT YYPQGEMKQK
     S