Y1143_ARATH
ID Y1143_ARATH Reviewed; 728 AA.
AC Q9M9S4; F4HUK3;
DT 03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=Probable LRR receptor-like serine/threonine-protein kinase At1g14390;
DE EC=2.7.11.1;
DE Flags: Precursor;
GN OrderedLocusNames=At1g14390; ORFNames=F14L17.16;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=20064227; DOI=10.1186/1471-2164-11-19;
RA Gou X., He K., Yang H., Yuan T., Lin H., Clouse S.D., Li J.;
RT "Genome-wide cloning and sequence analysis of leucine-rich repeat receptor-
RT like protein kinase genes in Arabidopsis thaliana.";
RL BMC Genomics 11:19-19(2010).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1;
CC -!- INTERACTION:
CC Q9M9S4; Q9SH71: At1g64210; NbExp=2; IntAct=EBI-16954682, EBI-20651385;
CC Q9M9S4; C0LGJ1: At1g74360; NbExp=2; IntAct=EBI-16954682, EBI-20652666;
CC Q9M9S4; Q9C7T7: CEPR2; NbExp=2; IntAct=EBI-16954682, EBI-16955712;
CC Q9M9S4; Q93ZS4: NIK3; NbExp=2; IntAct=EBI-16954682, EBI-17121474;
CC Q9M9S4; Q9FZ59: PEPR2; NbExp=2; IntAct=EBI-16954682, EBI-20652612;
CC Q9M9S4; Q9FXF2-2: RKF1; NbExp=2; IntAct=EBI-16954682, EBI-20652553;
CC Q9M9S4; P47735: RLK5; NbExp=2; IntAct=EBI-16954682, EBI-11420624;
CC Q9M9S4; P43298: TMK1; NbExp=2; IntAct=EBI-16954682, EBI-2023970;
CC Q9M9S4; Q9SIT1: TMK3; NbExp=2; IntAct=EBI-16954682, EBI-16896864;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. Ser/Thr protein
CC kinase family. {ECO:0000255|PROSITE-ProRule:PRU00159}.
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DR EMBL; AC012188; AAF43939.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE29157.2; -; Genomic_DNA.
DR EMBL; FJ708634; ACN59230.1; -; mRNA.
DR PIR; D86278; D86278.
DR RefSeq; NP_001319002.1; NM_001332118.1.
DR AlphaFoldDB; Q9M9S4; -.
DR SMR; Q9M9S4; -.
DR BioGRID; 23241; 66.
DR IntAct; Q9M9S4; 73.
DR STRING; 3702.AT1G14390.1; -.
DR iPTMnet; Q9M9S4; -.
DR PaxDb; Q9M9S4; -.
DR PRIDE; Q9M9S4; -.
DR ProteomicsDB; 242520; -.
DR EnsemblPlants; AT1G14390.1; AT1G14390.1; AT1G14390.
DR GeneID; 838001; -.
DR Gramene; AT1G14390.1; AT1G14390.1; AT1G14390.
DR KEGG; ath:AT1G14390; -.
DR Araport; AT1G14390; -.
DR eggNOG; ENOG502QTFC; Eukaryota.
DR HOGENOM; CLU_000288_108_0_1; -.
DR InParanoid; Q9M9S4; -.
DR OMA; QIAINCL; -.
DR OrthoDB; 496522at2759; -.
DR PhylomeDB; Q9M9S4; -.
DR PRO; PR:Q9M9S4; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9M9S4; baseline and differential.
DR Genevisible; Q9M9S4; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004672; F:protein kinase activity; IBA:GO_Central.
DR GO; GO:0106310; F:protein serine kinase activity; IEA:RHEA.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IEA:InterPro.
DR GO; GO:0046777; P:protein autophosphorylation; IBA:GO_Central.
DR Gene3D; 3.80.10.10; -; 2.
DR InterPro; IPR045272; ANXUR1-like.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR PANTHER; PTHR27003; PTHR27003; 1.
DR Pfam; PF00560; LRR_1; 3.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR SUPFAM; SSF56112; SSF56112; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 1: Evidence at protein level;
KW ATP-binding; Glycoprotein; Kinase; Leucine-rich repeat; Membrane;
KW Nucleotide-binding; Receptor; Reference proteome; Repeat;
KW Serine/threonine-protein kinase; Signal; Transferase; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..27
FT /evidence="ECO:0000255"
FT CHAIN 28..728
FT /note="Probable LRR receptor-like serine/threonine-protein
FT kinase At1g14390"
FT /id="PRO_0000387525"
FT TOPO_DOM 28..356
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 357..377
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 378..728
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REPEAT 74..96
FT /note="LRR 1"
FT REPEAT 106..130
FT /note="LRR 2"
FT REPEAT 131..155
FT /note="LRR 3"
FT REPEAT 157..178
FT /note="LRR 4"
FT REPEAT 179..202
FT /note="LRR 5"
FT REPEAT 204..224
FT /note="LRR 6"
FT REPEAT 225..248
FT /note="LRR 7"
FT REPEAT 249..272
FT /note="LRR 8"
FT REPEAT 274..295
FT /note="LRR 9"
FT DOMAIN 421..709
FT /note="Protein kinase"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT CARBOHYD 55
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 85
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 138
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 169
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 210
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 253
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 267
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 728 AA; 80059 MW; 57CFF33E4A969440 CRC64;
MHSSSKSQAF SLTFLLFLFL LPSVSESQLI SSESRTLLEI QKHLQYPPTL RSWSNWTNFC
YLPSSPSFKI LCFNGHVTEL TVTGNRTVKL PGRFSSDSLF TVLTKLSNLK TLSLVSLGIS
GPLPSQIIRL SSSLQSLNLS SNFISGNIPK EISSLKNLRS LVLANNLFNG SVPDLRGLSN
LQELNLGGNK LGPEVVPSLA SNLITISLKN NSFGSKIPEQ IKKLNKLQSL DLSSNKFTGS
IPRFLLSLPS LQNLSLAQNL LSGSLPNSSL CNSKLRILDV SRNLLTGKLP SCFSSKKQTV
LLFTFNCLSI NGSPSAKYQR PVTFCENEAK QAVAAVKSDT KDKERKEEDT GIELGLVIGI
IIGVILVSAV LAGLVLVRMR KSRSKEEPLE ANNVDQVTVC SNTTRSTTSK TVPDLRRVPQ
TMRSAVIGLS PYRVFSLEEL EEATNNFDAE NLCGEQLYKG CLREGIAVTV RCIKLKQKNS
TQNLAQQMEV LSKLRHMHLV SVLGHCIGTY QDHHPYAGST IFIVQEYISN GSLRDYLTDW
RKKEVLKWPQ RMSIAIGVAR GIQFLHTGVA PGIFGNNLEI ENVLLDETLT VKLSGYSIPL
PSKVGAESPS NEDGEKEDVY QFGVILIQII TGKVIAAASS ELGSLKLQLE NSLRDEPSVL
RSLADPCVRG TYAYESLRTT VEFAINCLCE DQRKRPSIED VVWNLQYTIQ VQQGWTSSEN
LGLGGSEL
