ID   Y1144_CLOD6             Reviewed;         235 AA.
AC   Q18B06;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   25-JUL-2006, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=UPF0758 protein CD630_11440;
GN   OrderedLocusNames=CD630_11440;
OS   Clostridioides difficile (strain 630) (Peptoclostridium difficile).
OC   Bacteria; Firmicutes; Clostridia; Eubacteriales; Peptostreptococcaceae;
OC   Clostridioides.
OX   NCBI_TaxID=272563;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=630;
RX   PubMed=16804543; DOI=10.1038/ng1830;
RA   Sebaihia M., Wren B.W., Mullany P., Fairweather N.F., Minton N.,
RA   Stabler R., Thomson N.R., Roberts A.P., Cerdeno-Tarraga A.M., Wang H.,
RA   Holden M.T.G., Wright A., Churcher C., Quail M.A., Baker S., Bason N.,
RA   Brooks K., Chillingworth T., Cronin A., Davis P., Dowd L., Fraser A.,
RA   Feltwell T., Hance Z., Holroyd S., Jagels K., Moule S., Mungall K.,
RA   Price C., Rabbinowitsch E., Sharp S., Simmonds M., Stevens K., Unwin L.,
RA   Whithead S., Dupuy B., Dougan G., Barrell B., Parkhill J.;
RT   "The multidrug-resistant human pathogen Clostridium difficile has a highly
RT   mobile, mosaic genome.";
RL   Nat. Genet. 38:779-786(2006).
CC   -!- SIMILARITY: Belongs to the UPF0758 family. {ECO:0000305}.
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DR   EMBL; AM180355; CAJ67997.1; -; Genomic_DNA.
DR   RefSeq; YP_001087636.1; NC_009089.1.
DR   AlphaFoldDB; Q18B06; -.
DR   SMR; Q18B06; -.
DR   STRING; 272563.CD630_11440; -.
DR   PRIDE; Q18B06; -.
DR   EnsemblBacteria; CAJ67997; CAJ67997; CD630_11440.
DR   KEGG; cdf:CD630_11440; -.
DR   KEGG; pdc:CDIF630_01291; -.
DR   PATRIC; fig|272563.120.peg.1193; -.
DR   eggNOG; COG2003; Bacteria.
DR   OMA; AMPDYEL; -.
DR   PhylomeDB; Q18B06; -.
DR   BioCyc; PDIF272563:G12WB-1274-MON; -.
DR   Proteomes; UP000001978; Chromosome.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd08071; MPN_DUF2466; 1.
DR   InterPro; IPR037518; MPN.
DR   InterPro; IPR025657; RadC_JAB.
DR   InterPro; IPR001405; UPF0758.
DR   InterPro; IPR020891; UPF0758_CS.
DR   PANTHER; PTHR30471; PTHR30471; 1.
DR   Pfam; PF04002; RadC; 1.
DR   TIGRFAMs; TIGR00608; radc; 1.
DR   PROSITE; PS50249; MPN; 1.
DR   PROSITE; PS01302; UPF0758; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Metal-binding; Metalloprotease; Protease; Reference proteome;
KW   Zinc.
FT   CHAIN           1..235
FT                   /note="UPF0758 protein CD630_11440"
FT                   /id="PRO_0000322683"
FT   DOMAIN          113..235
FT                   /note="MPN"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01182"
FT   MOTIF           184..197
FT                   /note="JAMM motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01182"
FT   BINDING         184
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01182"
FT   BINDING         186
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01182"
FT   BINDING         197
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01182"
SQ   SEQUENCE   235 AA;  26690 MW;  556513D6DA3CB91B CRC64;
     MIYLKKSFNS TIKVKEMAPE ERPREKMLAK GVKSLSNAEL LAILLRTGNK NKNAIELANY
     IINRDIQGIR HLEDMTIEEL CNIDGIGLSK STQIKAALEL GSRVASFKPI KYKIMNPWDI
     QRYYMDSLRY LKKEVFKAVL LNTKNEIISD VDVSIGTLSS SLVHPREVFK EAIRRSASKI
     IVMHNHPSGS VEPSREDKNI TSRLIKCGEI IGIEIIDHII IGDGLYFSFK ENMII