ID   Y1148_MYCTU             Reviewed;         454 AA.
AC   P9WM55; L0T8L3; O06548; P0A5D9;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 43.
DE   RecName: Full=Uncharacterized protein Rv1148c;
GN   OrderedLocusNames=Rv1148c; ORFNames=MTCI65.15c;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- SIMILARITY: Belongs to the Rv1128c/1148c/1588c/1702c/1945/3466 family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CCP43903.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AL123456; CCP43903.1; ALT_INIT; Genomic_DNA.
DR   PIR; E70554; E70554.
DR   RefSeq; NP_215664.1; NC_000962.3.
DR   RefSeq; WP_003898743.1; NC_018143.2.
DR   AlphaFoldDB; P9WM55; -.
DR   STRING; 83332.Rv1148c; -.
DR   PaxDb; P9WM55; -.
DR   DNASU; 885451; -.
DR   GeneID; 885451; -.
DR   KEGG; mtu:Rv1148c; -.
DR   PATRIC; fig|83332.12.peg.1289; -.
DR   TubercuList; Rv1148c; -.
DR   eggNOG; COG1403; Bacteria.
DR   OMA; RTWWIPP; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0004519; F:endonuclease activity; IEA:InterPro.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   CDD; cd00085; HNHc; 1.
DR   InterPro; IPR003870; DUF222.
DR   InterPro; IPR002711; HNH.
DR   InterPro; IPR003615; HNH_nuc.
DR   Pfam; PF02720; DUF222; 1.
DR   Pfam; PF01844; HNH; 1.
DR   SMART; SM00507; HNHc; 1.
PE   1: Evidence at protein level;
KW   Reference proteome.
FT   CHAIN           1..454
FT                   /note="Uncharacterized protein Rv1148c"
FT                   /id="PRO_0000103770"
FT   DOMAIN          364..405
FT                   /note="HNH"
SQ   SEQUENCE   454 AA;  49718 MW;  34C0C53AC638DC13 CRC64;
     MRSDTREEIS AALDAYHASL SRVLDLKCDA LTTPELLACL QRLEVERRRQ GAAEHALINQ
     LAGQACEEEL GGTLRTALAN RLHITPGEAS RRIAEAEDLG ERRALTGEPL PAQLTATAAA
     QREGKIGREH IKEIQAFFKE LSAAVDLGIR EAAEAQLAEL ATSRRPDHLH GLATQLMDWL
     HPDGNFSDQE RARKRGITMG KQEFDGMSRI SGLLTPELRA TIEAVLAKLA APGACNPDDQ
     TPLVDDTPDA DAVRRDTRSQ AQRNHDAFLA ALRGLLASGE LGQHKGLPVT IVVSTTLKEL
     EAATGKGVTG GGSRVPMSDL IRMASHANHY LALFDGAKPL ALYHTKRLAS PAQRIMLYAK
     DRGCSRPGCD APAYHSEVHH VTPWTTTHRT DINDLTLACG PDNRLVEKGW KTRKNAHGDT
     EWLPPPHLDH GQPRINRYHH PAKILCEQDD DEPH