CAPP_YERPE
ID CAPP_YERPE Reviewed; 878 AA.
AC Q8ZA84; Q0WA86;
DT 08-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 25-MAY-2022, entry version 132.
DE RecName: Full=Phosphoenolpyruvate carboxylase {ECO:0000255|HAMAP-Rule:MF_00595};
DE Short=PEPC {ECO:0000255|HAMAP-Rule:MF_00595};
DE Short=PEPCase {ECO:0000255|HAMAP-Rule:MF_00595};
DE EC=4.1.1.31 {ECO:0000255|HAMAP-Rule:MF_00595};
GN Name=ppc {ECO:0000255|HAMAP-Rule:MF_00595};
GN OrderedLocusNames=YPO3929, y0308, YP_3121;
OS Yersinia pestis.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Yersiniaceae; Yersinia.
OX NCBI_TaxID=632;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CO-92 / Biovar Orientalis;
RX PubMed=11586360; DOI=10.1038/35097083;
RA Parkhill J., Wren B.W., Thomson N.R., Titball R.W., Holden M.T.G.,
RA Prentice M.B., Sebaihia M., James K.D., Churcher C.M., Mungall K.L.,
RA Baker S., Basham D., Bentley S.D., Brooks K., Cerdeno-Tarraga A.-M.,
RA Chillingworth T., Cronin A., Davies R.M., Davis P., Dougan G., Feltwell T.,
RA Hamlin N., Holroyd S., Jagels K., Karlyshev A.V., Leather S., Moule S.,
RA Oyston P.C.F., Quail M.A., Rutherford K.M., Simmonds M., Skelton J.,
RA Stevens K., Whitehead S., Barrell B.G.;
RT "Genome sequence of Yersinia pestis, the causative agent of plague.";
RL Nature 413:523-527(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KIM10+ / Biovar Mediaevalis;
RX PubMed=12142430; DOI=10.1128/jb.184.16.4601-4611.2002;
RA Deng W., Burland V., Plunkett G. III, Boutin A., Mayhew G.F., Liss P.,
RA Perna N.T., Rose D.J., Mau B., Zhou S., Schwartz D.C., Fetherston J.D.,
RA Lindler L.E., Brubaker R.R., Plano G.V., Straley S.C., McDonough K.A.,
RA Nilles M.L., Matson J.S., Blattner F.R., Perry R.D.;
RT "Genome sequence of Yersinia pestis KIM.";
RL J. Bacteriol. 184:4601-4611(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=91001 / Biovar Mediaevalis;
RX PubMed=15368893; DOI=10.1093/dnares/11.3.179;
RA Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D.,
RA Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L.,
RA Dai R., Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H.,
RA Wang J., Huang P., Yang R.;
RT "Complete genome sequence of Yersinia pestis strain 91001, an isolate
RT avirulent to humans.";
RL DNA Res. 11:179-197(2004).
CC -!- FUNCTION: Forms oxaloacetate, a four-carbon dicarboxylic acid source
CC for the tricarboxylic acid cycle. {ECO:0000255|HAMAP-Rule:MF_00595}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=oxaloacetate + phosphate = hydrogencarbonate +
CC phosphoenolpyruvate; Xref=Rhea:RHEA:28370, ChEBI:CHEBI:16452,
CC ChEBI:CHEBI:17544, ChEBI:CHEBI:43474, ChEBI:CHEBI:58702; EC=4.1.1.31;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00595};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00595};
CC -!- SIMILARITY: Belongs to the PEPCase type 1 family. {ECO:0000255|HAMAP-
CC Rule:MF_00595}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAM83899.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAS63291.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AL590842; CAL22512.1; -; Genomic_DNA.
DR EMBL; AE009952; AAM83899.1; ALT_INIT; Genomic_DNA.
DR EMBL; AE017042; AAS63291.1; ALT_INIT; Genomic_DNA.
DR PIR; AE0478; AE0478.
DR RefSeq; WP_002209491.1; NZ_WUCM01000072.1.
DR RefSeq; YP_002348802.1; NC_003143.1.
DR AlphaFoldDB; Q8ZA84; -.
DR SMR; Q8ZA84; -.
DR IntAct; Q8ZA84; 5.
DR STRING; 214092.YPO3929; -.
DR PaxDb; Q8ZA84; -.
DR EnsemblBacteria; AAM83899; AAM83899; y0308.
DR EnsemblBacteria; AAS63291; AAS63291; YP_3121.
DR GeneID; 57974773; -.
DR KEGG; ype:YPO3929; -.
DR KEGG; ypk:y0308; -.
DR KEGG; ypm:YP_3121; -.
DR PATRIC; fig|214092.21.peg.4457; -.
DR eggNOG; COG2352; Bacteria.
DR HOGENOM; CLU_006557_2_0_6; -.
DR Proteomes; UP000000815; Chromosome.
DR Proteomes; UP000001019; Chromosome.
DR Proteomes; UP000002490; Chromosome.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0000287; F:magnesium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008964; F:phosphoenolpyruvate carboxylase activity; IBA:GO_Central.
DR GO; GO:0015977; P:carbon fixation; IEA:UniProtKB-UniRule.
DR GO; GO:0006107; P:oxaloacetate metabolic process; IEA:UniProtKB-UniRule.
DR GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
DR HAMAP; MF_00595; PEPcase_type1; 1.
DR InterPro; IPR021135; PEP_COase.
DR InterPro; IPR022805; PEP_COase_bac/pln-type.
DR InterPro; IPR018129; PEP_COase_Lys_AS.
DR InterPro; IPR033129; PEPCASE_His_AS.
DR InterPro; IPR015813; Pyrv/PenolPyrv_Kinase-like_dom.
DR PANTHER; PTHR30523; PTHR30523; 1.
DR Pfam; PF00311; PEPcase; 1.
DR PRINTS; PR00150; PEPCARBXLASE.
DR SUPFAM; SSF51621; SSF51621; 1.
DR PROSITE; PS00781; PEPCASE_1; 1.
DR PROSITE; PS00393; PEPCASE_2; 1.
PE 3: Inferred from homology;
KW Carbon dioxide fixation; Lyase; Magnesium; Reference proteome.
FT CHAIN 1..878
FT /note="Phosphoenolpyruvate carboxylase"
FT /id="PRO_0000166654"
FT ACT_SITE 137
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00595"
FT ACT_SITE 545
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00595"
FT CONFLICT 669
FT /note="S -> N (in Ref. 3; AAS63291)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 878 AA; 98324 MW; F57CE8ABD26287B4 CRC64;
MNEQYSAMRS NVSMLGTLLG DTIKEALGEH ILDRVETIRK LSKSSRAGNE ASRQELLTTL
QNLSNDELLP VARAFSQFLN LTNTAEQYHS ISPHGEAASN PEALAQLFTR LKDKKLSDQD
MRSAVDDLSI ELVLTAHPTE ITRRTLIHKL VEVNTCLSQL DHNDLADYER NKIMRRLRQL
VAQSWHTDEI RKLRPSPVDE AKWGFAVVEN SLWEGVPAFL REFNEQLENS LDYRLPVEAV
PIRFTSWMGG DRDGNPNVTA EITRHVLLLS RWKATDLFLR DIQVLVSELS MSECTPELRE
LAGGEEVLEP YRQLMKNVRT QLTNTQAYLE ARLKGERVLP PHDLLVSNDQ LWEPLYACYQ
SLKACGMEII ANGQLLDTLR RVRCFGVPLV RIDVRQESTR HTDAIAELTR YLGLGDYESW
SESDKQAFLV RELNSKRPLV PLKWEPSAET QEVLETCRVI AEAPQGSIAA YVISMAKVPS
DVLAVHLLLK EAGCPFTLPV APLFETLDDL NNADDVMTQL LGIDWYRGLI QGKQMVMIGY
SDSAKDAGVM AASWAQYRAQ DALIKTCEKA GITLTLFHGR GGSIGRGGAP AHAALLSQPP
GSLKGGLRVT EQGEMIRFKF GLPEVTISSL ALYAGAILEA NLLPPPEPKK EWIEVMDLLS
DASCDMYRSY VRENPEFVRY FRAATPELEL GKLPLGSRPA KRRPDGGVES LRAIPWIFAW
TQNRLMLPAW LGAGAGLQRA IDAGKQDVLA TMCRDWPFFS TRIGMLEMVF AKADLWLAEY
YDQRLVDKSL WPLGQQLRDQ LAADIKVVLA IANDDHLMAD LPWIAESIAL RNVYTDPLNV
LQAELLHRSR QQEHPDACVE QALMVTIAGV AAGMRNTG
