ID   Y1154_HAEIN             Reviewed;         440 AA.
AC   P45079;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 120.
DE   RecName: Full=Uncharacterized symporter HI_1154;
GN   OrderedLocusNames=HI_1154;
OS   Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=71421;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=7542800; DOI=10.1126/science.7542800;
RA   Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA   Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA   McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA   Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA   Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA   Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA   Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA   Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT   "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT   Rd.";
RL   Science 269:496-512(1995).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the dicarboxylate/amino acid:cation symporter
CC       (DAACS) (TC 2.A.23) family. {ECO:0000305}.
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DR   EMBL; L42023; AAC22809.1; -; Genomic_DNA.
DR   PIR; D64186; D64186.
DR   RefSeq; NP_439312.1; NC_000907.1.
DR   RefSeq; WP_005693469.1; NC_000907.1.
DR   AlphaFoldDB; P45079; -.
DR   SMR; P45079; -.
DR   EnsemblBacteria; AAC22809; AAC22809; HI_1154.
DR   KEGG; hin:HI_1154; -.
DR   PATRIC; fig|71421.8.peg.1205; -.
DR   eggNOG; COG1823; Bacteria.
DR   HOGENOM; CLU_019375_0_1_6; -.
DR   OMA; YFCTTII; -.
DR   PhylomeDB; P45079; -.
DR   BioCyc; HINF71421:G1GJ1-1187-MON; -.
DR   Proteomes; UP000000579; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0015184; F:L-cystine transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0015293; F:symporter activity; IEA:InterPro.
DR   GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR   Gene3D; 1.10.3860.10; -; 1.
DR   InterPro; IPR001991; Na-dicarboxylate_symporter.
DR   InterPro; IPR036458; Na:dicarbo_symporter_sf.
DR   PANTHER; PTHR42865; PTHR42865; 1.
DR   Pfam; PF00375; SDF; 1.
DR   SUPFAM; SSF118215; SSF118215; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..440
FT                   /note="Uncharacterized symporter HI_1154"
FT                   /id="PRO_0000202122"
FT   TRANSMEM        1..21
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        29..49
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        70..90
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        101..121
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        179..199
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        226..246
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        258..278
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        343..363
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        366..386
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        389..409
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   440 AA;  46492 MW;  F9298839559FD06A CRC64;
     MLLVNLAIFI AFLLLLAQLY RKTEKLGQTV FIGLLLGLLF GAVLQSAFEK PLLDKTLDWI
     NVVSNGYVRL LQMIVMPLVF VSILSAIARI NQTRSLGKVS VGVLSTLLIT TAISAAIGIA
     MVHLFDVSAA GLIVGDRELA AQGKVLDKAG QVSNLTVPAM LVSFIPKNPF ADLTGANPTS
     IISVVIFSAL LGVAALSLGK EDQALGERIA QGVETLNKLV MRLVRFVIRL TPYGVFALMI
     KMAATSKWAD IVNLGNFIVA SYAAIALMFV VHGILLFFVK VNPVDYYKKV LPTLSFAFTS
     RSSAATIPLN IETQTAKLGN NNVIANFAAT FGATIGQNGC GGIYPAMLAV MVAPMVGIDP
     FSFSYILTLI FVVAISSFGI AGVGGGATFA AIVVLSTLGL PLELIGLLIS IEPIIDMGRT
     ALNVNGAMVA GTITDRLLNK