ID   Y1155_METJA             Reviewed;         603 AA.
AC   Q58555;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=UPF0313 protein MJ1155;
GN   OrderedLocusNames=MJ1155;
OS   Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM
OS   10045 / NBRC 100440) (Methanococcus jannaschii).
OC   Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC   Methanocaldococcaceae; Methanocaldococcus.
OX   NCBI_TaxID=243232;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440;
RX   PubMed=8688087; DOI=10.1126/science.273.5278.1058;
RA   Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D., Sutton G.G.,
RA   Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D., Kerlavage A.R.,
RA   Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I., Overbeek R.,
RA   Kirkness E.F., Weinstock K.G., Merrick J.M., Glodek A., Scott J.L.,
RA   Geoghagen N.S.M., Weidman J.F., Fuhrmann J.L., Nguyen D., Utterback T.R.,
RA   Kelley J.M., Peterson J.D., Sadow P.W., Hanna M.C., Cotton M.D.,
RA   Roberts K.M., Hurst M.A., Kaine B.P., Borodovsky M., Klenk H.-P.,
RA   Fraser C.M., Smith H.O., Woese C.R., Venter J.C.;
RT   "Complete genome sequence of the methanogenic archaeon, Methanococcus
RT   jannaschii.";
RL   Science 273:1058-1073(1996).
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Evidence={ECO:0000305};
CC       Note=Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3
CC       cysteines and an exchangeable S-adenosyl-L-methionine. {ECO:0000305};
CC   -!- SIMILARITY: Belongs to the UPF0313 family. {ECO:0000305}.
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DR   EMBL; L77117; AAB99152.1; -; Genomic_DNA.
DR   PIR; B64444; B64444.
DR   RefSeq; WP_010870666.1; NC_000909.1.
DR   AlphaFoldDB; Q58555; -.
DR   STRING; 243232.MJ_1155; -.
DR   PRIDE; Q58555; -.
DR   EnsemblBacteria; AAB99152; AAB99152; MJ_1155.
DR   GeneID; 1452051; -.
DR   KEGG; mja:MJ_1155; -.
DR   eggNOG; arCOG04984; Archaea.
DR   HOGENOM; CLU_018288_2_0_2; -.
DR   InParanoid; Q58555; -.
DR   OMA; TCMYYTG; -.
DR   OrthoDB; 8457at2157; -.
DR   PhylomeDB; Q58555; -.
DR   Proteomes; UP000000805; Chromosome.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   GO; GO:0005506; F:iron ion binding; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.80.30.20; -; 1.
DR   HAMAP; MF_01251; UPF0313; 1.
DR   InterPro; IPR006638; Elp3/MiaB/NifB.
DR   InterPro; IPR020612; Methylthiotransferase_CS.
DR   InterPro; IPR007197; rSAM.
DR   InterPro; IPR023404; rSAM_horseshoe.
DR   InterPro; IPR022946; UPF0313.
DR   InterPro; IPR024560; UPF0313_C.
DR   InterPro; IPR013704; UPF0313_N.
DR   PANTHER; PTHR32331; PTHR32331; 1.
DR   Pfam; PF11842; DUF3362; 1.
DR   Pfam; PF04055; Radical_SAM; 1.
DR   Pfam; PF08497; Radical_SAM_N; 1.
DR   SFLD; SFLDS00029; Radical_SAM; 1.
DR   SFLD; SFLDG01069; UPF0313; 1.
DR   SMART; SM00729; Elp3; 1.
DR   TIGRFAMs; TIGR03904; SAM_YgiQ; 1.
DR   PROSITE; PS51918; RADICAL_SAM; 1.
PE   3: Inferred from homology;
KW   4Fe-4S; Iron; Iron-sulfur; Metal-binding; Reference proteome;
KW   S-adenosyl-L-methionine.
FT   CHAIN           1..603
FT                   /note="UPF0313 protein MJ1155"
FT                   /id="PRO_0000076404"
FT   DOMAIN          285..557
FT                   /note="Radical SAM core"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01266"
FT   BINDING         299
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /ligand_note="4Fe-4S-S-AdoMet"
FT                   /evidence="ECO:0000255"
FT   BINDING         303
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /ligand_note="4Fe-4S-S-AdoMet"
FT                   /evidence="ECO:0000255"
FT   BINDING         306
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /ligand_note="4Fe-4S-S-AdoMet"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   603 AA;  70425 MW;  B3AB76483FEE6444 CRC64;
     MFLPTTKEEM DEWGWEELDI IIVTGDAYID HYLFGASVVG RYLVEHGYRV GIIAQPDWKN
     LDDIKRLGKP NYFFAVTAGN LDSMLAHYTP QKRLRDFDSM SNEGIRKRPD RATIVYTNLI
     KRAFKGVPIA LGGIEASLRR FSHYDYWDNK VRKSVLIDSK ADILMYGMGE KSILAITKAL
     ESGENIKDLE INGTVVRVNE RKIGDIKERY ETKELPSHEE VVNSKEKYAE MHRKLMTMDK
     VIYQKVGNQY LVQFPPIYLT EKEMDEIYEM PFERRAHPSY SYVPGIVPVQ FSVVTHRGCF
     GGCSFCSILH HQGKVIQNRS ERSILKEIRK LLNHEDFKGV IQDIGAPTAN MYRMGCKKGL
     ADRCPKNCLY PEPCENLIIN HKPLIKLYRK IRDIVGDDVR VYVRSGVRYD LIMYDEEYGE
     DYIKELSKYH VSGRLKVAPE HISKKVCKAI QKPDGRLFKK FLEKYREIAE KVGGIKEVLP
     YWLIAHPNCS IKEMIELAEF IHKNNCYSRQ VQVFTPTPMT LSTTMYHTGI NPITNEKVYV
     PYTYREKKIQ KAICLYREEE NWEKALEGFK MVGYKGVIYR WIMEQMEKKK KQKKDKNKKN
     RLN