ID   Y1162_THEMA             Reviewed;         226 AA.
AC   Q9X0P5;
DT   18-OCT-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 1.
DT   25-MAY-2022, entry version 104.
DE   RecName: Full=UPF0173 metal-dependent hydrolase TM_1162 {ECO:0000255|HAMAP-Rule:MF_00457};
GN   OrderedLocusNames=TM_1162;
OS   Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826
OS   / MSB8).
OC   Bacteria; Thermotogae; Thermotogales; Thermotogaceae; Thermotoga.
OX   NCBI_TaxID=243274;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8;
RX   PubMed=10360571; DOI=10.1038/20601;
RA   Nelson K.E., Clayton R.A., Gill S.R., Gwinn M.L., Dodson R.J., Haft D.H.,
RA   Hickey E.K., Peterson J.D., Nelson W.C., Ketchum K.A., McDonald L.A.,
RA   Utterback T.R., Malek J.A., Linher K.D., Garrett M.M., Stewart A.M.,
RA   Cotton M.D., Pratt M.S., Phillips C.A., Richardson D.L., Heidelberg J.F.,
RA   Sutton G.G., Fleischmann R.D., Eisen J.A., White O., Salzberg S.L.,
RA   Smith H.O., Venter J.C., Fraser C.M.;
RT   "Evidence for lateral gene transfer between Archaea and Bacteria from
RT   genome sequence of Thermotoga maritima.";
RL   Nature 399:323-329(1999).
CC   -!- SIMILARITY: Belongs to the UPF0173 family. {ECO:0000255|HAMAP-
CC       Rule:MF_00457}.
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DR   EMBL; AE000512; AAD36238.1; -; Genomic_DNA.
DR   PIR; H72287; H72287.
DR   RefSeq; NP_228968.1; NC_000853.1.
DR   RefSeq; WP_004080208.1; NZ_CP011107.1.
DR   PDB; 3X2X; X-ray; 3.42 A; A/B/C=1-226.
DR   PDB; 3X2Y; X-ray; 2.67 A; A/B/C=1-226.
DR   PDB; 3X2Z; X-ray; 2.33 A; A/B/C=1-226.
DR   PDB; 3X30; X-ray; 1.92 A; A=1-226.
DR   PDBsum; 3X2X; -.
DR   PDBsum; 3X2Y; -.
DR   PDBsum; 3X2Z; -.
DR   PDBsum; 3X30; -.
DR   AlphaFoldDB; Q9X0P5; -.
DR   SMR; Q9X0P5; -.
DR   STRING; 243274.THEMA_08525; -.
DR   EnsemblBacteria; AAD36238; AAD36238; TM_1162.
DR   KEGG; tma:TM1162; -.
DR   eggNOG; COG2220; Bacteria.
DR   InParanoid; Q9X0P5; -.
DR   OMA; WHGHSTW; -.
DR   OrthoDB; 767622at2; -.
DR   Proteomes; UP000008183; Chromosome.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.60.15.10; -; 1.
DR   HAMAP; MF_00457; UPF0173; 1.
DR   InterPro; IPR001279; Metallo-B-lactamas.
DR   InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR   InterPro; IPR022877; UPF0173.
DR   Pfam; PF12706; Lactamase_B_2; 1.
DR   SMART; SM00849; Lactamase_B; 1.
DR   SUPFAM; SSF56281; SSF56281; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Hydrolase; Reference proteome.
FT   CHAIN           1..226
FT                   /note="UPF0173 metal-dependent hydrolase TM_1162"
FT                   /id="PRO_0000156388"
FT   STRAND          1..5
FT                   /evidence="ECO:0007829|PDB:3X30"
FT   STRAND          11..22
FT                   /evidence="ECO:0007829|PDB:3X30"
FT   HELIX           35..37
FT                   /evidence="ECO:0007829|PDB:3X30"
FT   STRAND          42..45
FT                   /evidence="ECO:0007829|PDB:3X30"
FT   HELIX           51..54
FT                   /evidence="ECO:0007829|PDB:3X30"
FT   HELIX           57..64
FT                   /evidence="ECO:0007829|PDB:3X30"
FT   STRAND          67..71
FT                   /evidence="ECO:0007829|PDB:3X30"
FT   HELIX           72..80
FT                   /evidence="ECO:0007829|PDB:3X30"
FT   STRAND          84..88
FT                   /evidence="ECO:0007829|PDB:3X30"
FT   STRAND          93..96
FT                   /evidence="ECO:0007829|PDB:3X30"
FT   STRAND          99..105
FT                   /evidence="ECO:0007829|PDB:3X30"
FT   STRAND          111..114
FT                   /evidence="ECO:0007829|PDB:3X30"
FT   STRAND          117..120
FT                   /evidence="ECO:0007829|PDB:3X30"
FT   STRAND          125..131
FT                   /evidence="ECO:0007829|PDB:3X30"
FT   STRAND          134..138
FT                   /evidence="ECO:0007829|PDB:3X30"
FT   HELIX           146..154
FT                   /evidence="ECO:0007829|PDB:3X30"
FT   STRAND          157..162
FT                   /evidence="ECO:0007829|PDB:3X30"
FT   STRAND          166..168
FT                   /evidence="ECO:0007829|PDB:3X2Z"
FT   HELIX           171..181
FT                   /evidence="ECO:0007829|PDB:3X30"
FT   STRAND          184..190
FT                   /evidence="ECO:0007829|PDB:3X30"
FT   STRAND          192..194
FT                   /evidence="ECO:0007829|PDB:3X30"
FT   HELIX           195..197
FT                   /evidence="ECO:0007829|PDB:3X30"
FT   HELIX           201..210
FT                   /evidence="ECO:0007829|PDB:3X30"
FT   STRAND          223..226
FT                   /evidence="ECO:0007829|PDB:3X30"
SQ   SEQUENCE   226 AA;  24644 MW;  FB10EA6E72E873FF CRC64;
     MKVTFLGHAV VLIEGKKNII IDPFISGNPV CPVKLEGLPK IDYILVTHGH GDHLGDAVEI
     AKKNDATVIS NYEICHYLGK KGVKTHAMHI GGSYLFDFGR VKMTPAVHGS GILDGDSMIY
     GGNPSGFLIT IEGKKIYHAG DTGLTREMEL LAEENVDVAF LPIGGNFVMD VEDAVRAAVM
     IKPKKVVPMH YGTWELIFAD VELFKKKVEE KGVECVILEP GESLEL