ID   Y1163_HAEIN             Reviewed;        1027 AA.
AC   Q57252; O05046;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 121.
DE   RecName: Full=Uncharacterized protein HI_1163 {ECO:0000305};
GN   OrderedLocusNames=HI_1163;
OS   Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=71421;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=7542800; DOI=10.1126/science.7542800;
RA   Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA   Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA   McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA   Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA   Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA   Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA   Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA   Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT   "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT   Rd.";
RL   Science 269:496-512(1995).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY.
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=10675023;
RX   DOI=10.1002/(sici)1522-2683(20000101)21:2<411::aid-elps411>3.0.co;2-4;
RA   Langen H., Takacs B., Evers S., Berndt P., Lahm H.W., Wipf B., Gray C.,
RA   Fountoulakis M.;
RT   "Two-dimensional map of the proteome of Haemophilus influenzae.";
RL   Electrophoresis 21:411-429(2000).
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000250|UniProtKB:P77748};
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC         Evidence={ECO:0000250|UniProtKB:P77748};
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DR   EMBL; L42023; AAC22818.1; -; Genomic_DNA.
DR   PIR; B64187; B64187.
DR   RefSeq; NP_439321.1; NC_000907.1.
DR   RefSeq; WP_005694279.1; NC_000907.1.
DR   AlphaFoldDB; Q57252; -.
DR   STRING; 71421.HI_1163; -.
DR   EnsemblBacteria; AAC22818; AAC22818; HI_1163.
DR   KEGG; hin:HI_1163; -.
DR   PATRIC; fig|71421.8.peg.1215; -.
DR   eggNOG; COG0247; Bacteria.
DR   eggNOG; COG0277; Bacteria.
DR   HOGENOM; CLU_010756_1_0_6; -.
DR   OMA; FKPNGKP; -.
DR   PhylomeDB; Q57252; -.
DR   BioCyc; HINF71421:G1GJ1-1197-MON; -.
DR   Proteomes; UP000000579; Chromosome.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0004458; F:D-lactate dehydrogenase (cytochrome) activity; IBA:GO_Central.
DR   GO; GO:0008720; F:D-lactate dehydrogenase activity; IBA:GO_Central.
DR   GO; GO:0071949; F:FAD binding; IEA:InterPro.
DR   GO; GO:0050660; F:flavin adenine dinucleotide binding; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:1903457; P:lactate catabolic process; IBA:GO_Central.
DR   Gene3D; 3.30.465.10; -; 1.
DR   InterPro; IPR017896; 4Fe4S_Fe-S-bd.
DR   InterPro; IPR017900; 4Fe4S_Fe_S_CS.
DR   InterPro; IPR016166; FAD-bd_PCMH.
DR   InterPro; IPR036318; FAD-bd_PCMH-like_sf.
DR   InterPro; IPR016169; FAD-bd_PCMH_sub2.
DR   InterPro; IPR016164; FAD-linked_Oxase-like_C.
DR   InterPro; IPR004113; FAD-linked_oxidase_C.
DR   InterPro; IPR006094; Oxid_FAD_bind_N.
DR   Pfam; PF02913; FAD-oxidase_C; 1.
DR   Pfam; PF01565; FAD_binding_4; 1.
DR   Pfam; PF13183; Fer4_8; 1.
DR   SUPFAM; SSF55103; SSF55103; 1.
DR   SUPFAM; SSF56176; SSF56176; 1.
DR   PROSITE; PS00198; 4FE4S_FER_1; 1.
DR   PROSITE; PS51379; 4FE4S_FER_2; 1.
DR   PROSITE; PS51387; FAD_PCMH; 1.
PE   1: Evidence at protein level;
KW   4Fe-4S; FAD; Flavoprotein; Iron; Iron-sulfur; Metal-binding;
KW   Reference proteome.
FT   CHAIN           1..1027
FT                   /note="Uncharacterized protein HI_1163"
FT                   /id="PRO_0000168995"
FT   DOMAIN          48..284
FT                   /note="FAD-binding PCMH-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00718"
FT   DOMAIN          665..696
FT                   /note="4Fe-4S ferredoxin-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00711"
SQ   SEQUENCE   1027 AA;  116743 MW;  A53D3D966E264761 CRC64;
     MLPNLNRIPQ VEQYVLDYLD DLQCQHFEGD IATNYADRLS LATDNSVYQQ LPQAILFPKT
     VADIVRITKL ANLPEYQSIS FTPRGGGTGT NGQSINNNII VDLSRHMTAI LELNVKERWV
     RVQAGVVKDQ LNQFLKPHGL FFAPELSTSN RATLGGMINT DASGQGSLQY GKTSNHVLAL
     RAVLINGEIL DTSAVNSVDV LENIDALELS ESSKKLHQTI AQHCKEKRAA IIKDLPQLNR
     FLTGYDLKNV FNEDESEFNL TRILTGSEGS LAFICEAKLN LLLIPQYRTL INIKYRSFDA
     ALRNAPFMVK ANALSVETVD SKVLNLAKQD IIWHSVNELL TEDEKDPILG LNIVEFAGNN
     KEKIDRQVTA LCRLLDEKIE HNQDHIIGYQ VCSDLPSIER IYAMRKKAVG LLGNAKGAAK
     PIPFVEDTCV PPENLADYIS EFRALLDQHN LQYGMFGHVD AGVLHVRPAL DLCDKEQVKL
     FKQISDEVAE LTIKYGGLLW GEHGKGVRSH YGEKFFTPEL WHELRYIKTL FDPNNRLNPG
     KICTPLDSKD ELYSILSPMR ADKDRQIPIQ IRDEFKGAMN CNGNGLCFNF DEHSIMCPSM
     KVSKNRVFSP KGRAAMVREW LRLMANENVS PEQLDFRKTE IKLTALVKRL SNTVQKWRGN
     YDFSHEVKAA MDTCLACKAC ASQCPIKIDV PSFRAKFFHF YHSRYLRPTK DHIVANLEIA
     APYMAKQAKF FNYFTKLKVT QTLVEKTLGM TDLPLLSEPS LQQQLVEIHY QGKSLEELES
     LSAVEKNDIL FIVQDPYTSY YDAKVIRDFV MLTQKLGFKP ILLPFKPNGK AMHIKGFLKR
     FSKTAQNQAE FLNRMAKLGI PLVGVDPAIV LSYRDEYKEA LQEKRGDFHV LTAHEWLKQR
     LQNADLQEKL KNIAKTDRTL GWYLFPHCTE STFMPNSPKE WQEIFGRFGQ QLNVEKVGCC
     GMAGVFGHEV QNQKMSREIY DVSWHKKLHG KDPHFCLATG YSCRSQVKRY EHVVLKHPVQ
     ALLEVLK