ID   Y1167_MYCLE             Reviewed;         362 AA.
AC   P53425;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   03-AUG-2022, entry version 109.
DE   RecName: Full=Uncharacterized aminopeptidase ML1167;
DE            EC=3.4.11.- {ECO:0000250|UniProtKB:Q52VH2};
GN   OrderedLocusNames=ML1167; ORFNames=B1549_C2_208;
OS   Mycobacterium leprae (strain TN).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium.
OX   NCBI_TaxID=272631;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Smith D.R., Robison K.;
RL   Submitted (SEP-1994) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TN;
RX   PubMed=11234002; DOI=10.1038/35059006;
RA   Cole S.T., Eiglmeier K., Parkhill J., James K.D., Thomson N.R.,
RA   Wheeler P.R., Honore N., Garnier T., Churcher C.M., Harris D.E.,
RA   Mungall K.L., Basham D., Brown D., Chillingworth T., Connor R.,
RA   Davies R.M., Devlin K., Duthoy S., Feltwell T., Fraser A., Hamlin N.,
RA   Holroyd S., Hornsby T., Jagels K., Lacroix C., Maclean J., Moule S.,
RA   Murphy L.D., Oliver K., Quail M.A., Rajandream M.A., Rutherford K.M.,
RA   Rutter S., Seeger K., Simon S., Simmonds M., Skelton J., Squares R.,
RA   Squares S., Stevens K., Taylor K., Whitehead S., Woodward J.R.,
RA   Barrell B.G.;
RT   "Massive gene decay in the leprosy bacillus.";
RL   Nature 409:1007-1011(2001).
CC   -!- FUNCTION: Aminopeptidase. {ECO:0000250|UniProtKB:Q52VH2}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the peptidase S58 family. {ECO:0000305}.
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DR   EMBL; U00014; AAA50889.1; -; Genomic_DNA.
DR   EMBL; AL583921; CAC31548.1; -; Genomic_DNA.
DR   PIR; S72794; S72794.
DR   RefSeq; NP_301852.1; NC_002677.1.
DR   AlphaFoldDB; P53425; -.
DR   SMR; P53425; -.
DR   STRING; 272631.ML1167; -.
DR   MEROPS; P01.101; -.
DR   EnsemblBacteria; CAC31548; CAC31548; CAC31548.
DR   KEGG; mle:ML1167; -.
DR   PATRIC; fig|272631.5.peg.2122; -.
DR   Leproma; ML1167; -.
DR   eggNOG; COG3191; Bacteria.
DR   HOGENOM; CLU_044458_1_0_11; -.
DR   OMA; PHFWAAP; -.
DR   Proteomes; UP000000806; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004177; F:aminopeptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   InterPro; IPR016117; ArgJ-like_dom_sf.
DR   InterPro; IPR005321; Peptidase_S58_DmpA.
DR   PANTHER; PTHR36512; PTHR36512; 1.
DR   Pfam; PF03576; Peptidase_S58; 1.
DR   SUPFAM; SSF56266; SSF56266; 1.
PE   3: Inferred from homology;
KW   Aminopeptidase; Cell membrane; Hydrolase; Membrane; Protease;
KW   Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..362
FT                   /note="Uncharacterized aminopeptidase ML1167"
FT                   /id="PRO_0000103810"
FT   TRANSMEM        32..52
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        75..95
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        106..126
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        148..168
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        176..196
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        287..307
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        329..349
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   362 AA;  36105 MW;  0A630F4AEC974A7A CRC64;
     MILMAAPMNS ITDISGIQVG HYHRLDPDAS LGAGWACGVT VVLTPPGTVG AVDCRGGVPG
     TRETDLLDPA NSVRFVDAVL LAGGSAYGLA AADGVMRWLE EHERGVVMLG GVVPIVPGAV
     IFDLSVGDFH CRPTAEFGYL ACQAAYDAAV GGQDATVAVG TVGAGVGARA GVLKGGVGTA
     SITLESGPTV GAVVVVNSVG DVVDRATGLP WMTDLIDEFA LRPPSPEQIA GFAQLKSPLS
     ALNTTIGVVA TDATLSPAAC QRVAMAAQDG LARTIRPAHT ALDGDTVFAL ATGAVEATAT
     ADVPVAMSPE TGLITEVGAA ADDCLARAVL VAVLAAESVA GIPTYCGMFP GAFGTTIGGG
     NR