ID   Y1171_MYCLE             Reviewed;         251 AA.
AC   P53426; Q9CC73;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   03-AUG-2022, entry version 110.
DE   RecName: Full=Uncharacterized protein ML1171;
GN   OrderedLocusNames=ML1171; ORFNames=B1549_C3_240;
OS   Mycobacterium leprae (strain TN).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium.
OX   NCBI_TaxID=272631;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Smith D.R., Robison K.;
RL   Submitted (SEP-1994) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TN;
RX   PubMed=11234002; DOI=10.1038/35059006;
RA   Cole S.T., Eiglmeier K., Parkhill J., James K.D., Thomson N.R.,
RA   Wheeler P.R., Honore N., Garnier T., Churcher C.M., Harris D.E.,
RA   Mungall K.L., Basham D., Brown D., Chillingworth T., Connor R.,
RA   Davies R.M., Devlin K., Duthoy S., Feltwell T., Fraser A., Hamlin N.,
RA   Holroyd S., Hornsby T., Jagels K., Lacroix C., Maclean J., Moule S.,
RA   Murphy L.D., Oliver K., Quail M.A., Rajandream M.A., Rutherford K.M.,
RA   Rutter S., Seeger K., Simon S., Simmonds M., Skelton J., Squares R.,
RA   Squares S., Stevens K., Taylor K., Whitehead S., Woodward J.R.,
RA   Barrell B.G.;
RT   "Massive gene decay in the leprosy bacillus.";
RL   Nature 409:1007-1011(2001).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: To M.tuberculosis Rv1337. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAC31552.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; U00014; AAA50900.1; -; Genomic_DNA.
DR   EMBL; AL583921; CAC31552.1; ALT_INIT; Genomic_DNA.
DR   PIR; E87055; E87055.
DR   PIR; S72791; S72791.
DR   RefSeq; WP_010908177.1; NC_002677.1.
DR   AlphaFoldDB; P53426; -.
DR   STRING; 272631.ML1171; -.
DR   MEROPS; S54.029; -.
DR   EnsemblBacteria; CAC31552; CAC31552; CAC31552.
DR   KEGG; mle:ML1171; -.
DR   Leproma; ML1171; -.
DR   eggNOG; COG0705; Bacteria.
DR   HOGENOM; CLU_067823_2_0_11; -.
DR   Proteomes; UP000000806; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR   Gene3D; 1.20.1540.10; -; 1.
DR   InterPro; IPR022764; Peptidase_S54_rhomboid_dom.
DR   InterPro; IPR035952; Rhomboid-like_sf.
DR   Pfam; PF01694; Rhomboid; 1.
DR   SUPFAM; SSF144091; SSF144091; 1.
PE   4: Predicted;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..251
FT                   /note="Uncharacterized protein ML1171"
FT                   /id="PRO_0000103813"
FT   TRANSMEM        48..68
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        88..108
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        110..130
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        132..152
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        158..178
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        184..204
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        209..229
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   251 AA;  27064 MW;  BF847E050599DFC4 CRC64;
     MTPTGDWYKG GDEVGAPSAC GGGSALMTLP EKNLGYKPET ETNRRLRWMV GGVTILTFMA
     LLYLVELIDQ LTRHSLDNNG IRLLKTDVLW GISFAPVLHA NWQHLVANTI PLLVLGFLIA
     LAGLSRFIWV TAMVWIFGGS ATWLIGNMGS SFGPTDHIGV SGLIFGWLAF LLVFGLFVRR
     GWDIIGCMVL FAYGGVLLGV MPVLGRCGGV SWQGHLCGAI SGVVAAYLLS APERKTRALK
     EAGTDSPRLK T