ID   Y117_HELPJ              Reviewed;         308 AA.
AC   Q9ZMV6;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=UPF0026 protein jhp_0109;
GN   OrderedLocusNames=jhp_0109;
OS   Helicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99).
OC   Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC   Helicobacteraceae; Helicobacter.
OX   NCBI_TaxID=85963;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=J99 / ATCC 700824;
RX   PubMed=9923682; DOI=10.1038/16495;
RA   Alm R.A., Ling L.-S.L., Moir D.T., King B.L., Brown E.D., Doig P.C.,
RA   Smith D.R., Noonan B., Guild B.C., deJonge B.L., Carmel G., Tummino P.J.,
RA   Caruso A., Uria-Nickelsen M., Mills D.M., Ives C., Gibson R., Merberg D.,
RA   Mills S.D., Jiang Q., Taylor D.E., Vovis G.F., Trust T.J.;
RT   "Genomic sequence comparison of two unrelated isolates of the human gastric
RT   pathogen Helicobacter pylori.";
RL   Nature 397:176-180(1999).
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Evidence={ECO:0000305};
CC       Note=Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3
CC       cysteines and an exchangeable S-adenosyl-L-methionine. {ECO:0000305};
CC   -!- SIMILARITY: Belongs to the UPF0026 family. {ECO:0000305}.
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DR   EMBL; AE001439; AAD05696.1; -; Genomic_DNA.
DR   PIR; C71972; C71972.
DR   RefSeq; WP_001040769.1; NZ_CP011330.1.
DR   AlphaFoldDB; Q9ZMV6; -.
DR   SMR; Q9ZMV6; -.
DR   STRING; 85963.jhp_0109; -.
DR   EnsemblBacteria; AAD05696; AAD05696; jhp_0109.
DR   KEGG; hpj:jhp_0109; -.
DR   PATRIC; fig|85963.30.peg.919; -.
DR   eggNOG; COG0731; Bacteria.
DR   OMA; CIYCELG; -.
DR   Proteomes; UP000000804; Chromosome.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   Gene3D; 3.20.20.70; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR040084; GTPase_Obg.
DR   InterPro; IPR007197; rSAM.
DR   Pfam; PF04055; Radical_SAM; 1.
DR   SFLD; SFLDS00029; Radical_SAM; 1.
DR   SFLD; SFLDG01083; Uncharacterised_Radical_SAM_Su; 1.
DR   PROSITE; PS51918; RADICAL_SAM; 1.
PE   3: Inferred from homology;
KW   4Fe-4S; Iron; Iron-sulfur; Metal-binding; S-adenosyl-L-methionine.
FT   CHAIN           1..308
FT                   /note="UPF0026 protein jhp_0109"
FT                   /id="PRO_0000217865"
FT   DOMAIN          18..247
FT                   /note="Radical SAM core"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01266"
FT   BINDING         33
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /ligand_note="4Fe-4S-S-AdoMet"
FT                   /evidence="ECO:0000255"
FT   BINDING         37
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /ligand_note="4Fe-4S-S-AdoMet"
FT                   /evidence="ECO:0000255"
FT   BINDING         40
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /ligand_note="4Fe-4S-S-AdoMet"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   308 AA;  34341 MW;  900F63D6CFB6ACA2 CRC64;
     MAKENLPIVF GPVLSRRFGK SLGVDLSPSK KQCNYNCIYC ELGKAKPIER MEEVIKVETL
     ISTIQNALNN LTTPIDVLTI TANGEPTLYP HLLELIQSIK PFLKGVKTLI LSNGSLFYEP
     KVQQALKEFD IVKFSLDAID LKAFERVDKP YSKDINKILE GILSFSQIYQ GQLVAEVLLI
     KGVNDSANNL KLIADFLKKI NTARVDLSTI DRPSSFKAPK LSEDELLKCS LFFEGLCVSL
     PKRSTAQAKK LVSCGIDELL ALISRRPLSA EEAPLILDPN AFKHLETLLN HKQITIKKVG
     SLEFYCAF