Y117_HELPY
ID Y117_HELPY Reviewed; 308 AA.
AC P56080;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 1.
DT 03-AUG-2022, entry version 97.
DE RecName: Full=UPF0026 protein HP_0117;
GN OrderedLocusNames=HP_0117;
OS Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori).
OC Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC Helicobacteraceae; Helicobacter.
OX NCBI_TaxID=85962;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700392 / 26695;
RX PubMed=9252185; DOI=10.1038/41483;
RA Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G.,
RA Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A.,
RA Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N.,
RA Loftus B.J., Richardson D.L., Dodson R.J., Khalak H.G., Glodek A.,
RA McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E.,
RA Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D.,
RA Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S.,
RA Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C.;
RT "The complete genome sequence of the gastric pathogen Helicobacter
RT pylori.";
RL Nature 388:539-547(1997).
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Evidence={ECO:0000305};
CC Note=Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3
CC cysteines and an exchangeable S-adenosyl-L-methionine. {ECO:0000305};
CC -!- SIMILARITY: Belongs to the UPF0026 family. {ECO:0000305}.
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DR EMBL; AE000511; AAD07185.1; -; Genomic_DNA.
DR PIR; E64534; E64534.
DR RefSeq; NP_206917.1; NC_000915.1.
DR RefSeq; WP_001040794.1; NC_018939.1.
DR AlphaFoldDB; P56080; -.
DR SMR; P56080; -.
DR DIP; DIP-3297N; -.
DR IntAct; P56080; 2.
DR MINT; P56080; -.
DR STRING; 85962.C694_00580; -.
DR PaxDb; P56080; -.
DR EnsemblBacteria; AAD07185; AAD07185; HP_0117.
DR KEGG; hpy:HP_0117; -.
DR PATRIC; fig|85962.47.peg.126; -.
DR eggNOG; COG0731; Bacteria.
DR OMA; CIYCELG; -.
DR PhylomeDB; P56080; -.
DR Proteomes; UP000000429; Chromosome.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR Gene3D; 3.20.20.70; -; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR040084; GTPase_Obg.
DR InterPro; IPR007197; rSAM.
DR Pfam; PF04055; Radical_SAM; 1.
DR SFLD; SFLDS00029; Radical_SAM; 1.
DR SFLD; SFLDG01083; Uncharacterised_Radical_SAM_Su; 1.
DR PROSITE; PS51918; RADICAL_SAM; 1.
PE 3: Inferred from homology;
KW 4Fe-4S; Iron; Iron-sulfur; Metal-binding; Reference proteome;
KW S-adenosyl-L-methionine.
FT CHAIN 1..308
FT /note="UPF0026 protein HP_0117"
FT /id="PRO_0000217864"
FT DOMAIN 18..248
FT /note="Radical SAM core"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01266"
FT BINDING 33
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /ligand_note="4Fe-4S-S-AdoMet"
FT /evidence="ECO:0000255"
FT BINDING 37
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /ligand_note="4Fe-4S-S-AdoMet"
FT /evidence="ECO:0000255"
FT BINDING 40
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /ligand_note="4Fe-4S-S-AdoMet"
FT /evidence="ECO:0000255"
SQ SEQUENCE 308 AA; 34405 MW; BBAA863283FBDF4B CRC64;
MAKENPPIVF GPVLSRRFGK SLGVDLSPSK KQCNYNCIYC ELGKAKPIER MEEVIKVETL
INAIQNALNN LTTPIDVLTI TANGEPTLYP HLLELIQSIK PFLKGVKTLI LSNGSLFYEP
KVQQALKEFD IVKFSLDAID LKAFERVDKP YSKDINKILE GILRFSQIYQ GQLVAEVLLI
KGVNDSANNL KLIAAFLKQI NIARVDLSTI DRPSSFKAPK LSEDELLKCS LFFEGLCVSL
PKRSITQAKK LISCGIDELL ALISRRPLSA EEAPLILDSN AFKHLETLLN HKQITIKKVG
SLEFYCAF
