ID   CAPS2_SIFVH             Reviewed;         167 AA.
AC   Q914J5;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   23-FEB-2022, entry version 38.
DE   RecName: Full=Major capsid protein 2;
DE   AltName: Full=MCP2;
GN   Name=SIFV0035;
OS   Sulfolobus islandicus filamentous virus (isolate Iceland/Hveragerdi)
OS   (SIFV).
OC   Viruses; Adnaviria; Zilligvirae; Taleaviricota; Tokiviricetes;
OC   Ligamenvirales; Lipothrixviridae; Betalipothrixvirus.
OX   NCBI_TaxID=654908;
OH   NCBI_TaxID=43080; Sulfolobus islandicus.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=10662621; DOI=10.1006/viro.1999.0105;
RA   Arnold H.P., Zillig W., Ziese U., Holz I., Crosby M., Utterback T.,
RA   Weidmann J.F., Umayam L.A., Teffera K., Kristjanson J.K., Klenk H.P.,
RA   Nelson K.E., Fraser C.M.;
RT   "A novel lipothrixvirus, SIFV, of the extremely thermophilic crenarchaeon
RT   Sulfolobus.";
RL   Virology 267:252-266(2000).
RN   [2] {ECO:0007744|PDB:6WQ2}
RP   STRUCTURE BY ELECTRON MICROSCOPY (4.00 ANGSTROMS), SUBUNIT, DOMAIN,
RP   FUNCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=32759221; DOI=10.1073/pnas.2011125117;
RA   Wang F., Baquero D.P., Beltran L.C., Su Z., Osinski T., Zheng W.,
RA   Prangishvili D., Krupovic M., Egelman E.H.;
RT   "Structures of filamentous viruses infecting hyperthermophilic archaea
RT   explain DNA stabilization in extreme environments.";
RL   Proc. Natl. Acad. Sci. U.S.A. 117:19643-19652(2020).
CC   -!- FUNCTION: Self-assembles to form a helical, filamentous nucleocapsid
CC       mesuring 1980 nm in length and 24 nm in width. Together with capsid
CC       protein 1, wraps arounds the DNA and maintains it in an A-form. Capsid
CC       proteins probably maintain the DNA in A-form by non-specific
CC       desolvation and specific coordination of the DNA phosphate groups by
CC       positively charged residues. This certainly protects the viral DNA
CC       under conditions such as the extreme desiccation of its host.
CC       {ECO:0000269|PubMed:32759221}.
CC   -!- SUBUNIT: Heterodimer composed of major capsid protein 1 and major
CC       capsid protein 2. {ECO:0000269|PubMed:32759221}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000269|PubMed:32759221}.
CC   -!- DOMAIN: The N-terminus projects into a DNA groove.
CC       {ECO:0000269|PubMed:32759221}.
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DR   EMBL; AF440571; AAL27746.1; -; Genomic_DNA.
DR   RefSeq; NP_445700.1; NC_003214.2.
DR   PDB; 6WQ2; EM; 4.00 A; A/B/C/D/E/F/G/H/I/J/K/L/M/N/P/R/T=1-167.
DR   PDBsum; 6WQ2; -.
DR   SMR; Q914J5; -.
DR   GeneID; 922296; -.
DR   KEGG; vg:922296; -.
DR   Proteomes; UP000007017; Genome.
DR   GO; GO:0019029; C:helical viral capsid; IDA:UniProtKB.
DR   GO; GO:0003677; F:DNA binding; IDA:UniProtKB.
PE   1: Evidence at protein level;
KW   3D-structure; DNA-binding; Reference proteome; Virion.
FT   CHAIN           1..167
FT                   /note="Major capsid protein 2"
FT                   /id="PRO_0000385447"
SQ   SEQUENCE   167 AA;  18876 MW;  02F4738AD033251E CRC64;
     MARRNRRLSS ASVYRYYLKR ISMNIGTTGH VNGLSIAGNP EIMRAIARLS EQETYNWVTD
     YAPSHLAKEV VKQISGKYNI PGAYQGLLMA FAEKVLANYI LDYKGEPLVE IHHNFLWELM
     QRQSGAGLGV TSGFIYTFVR KDGKPVTVDM SKVLTEIEDA LFKLVKK