ID   Y1194_METTH             Reviewed;         331 AA.
AC   O27262;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=Probable deacetylase MTH_1194 {ECO:0000305};
DE            EC=3.5.1.- {ECO:0000250|UniProtKB:Q48935};
GN   OrderedLocusNames=MTH_1194;
OS   Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM
OS   10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum).
OC   Archaea; Euryarchaeota; Methanomada group; Methanobacteria;
OC   Methanobacteriales; Methanobacteriaceae; Methanothermobacter.
OX   NCBI_TaxID=187420;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H;
RX   PubMed=9371463; DOI=10.1128/jb.179.22.7135-7155.1997;
RA   Smith D.R., Doucette-Stamm L.A., Deloughery C., Lee H.-M., Dubois J.,
RA   Aldredge T., Bashirzadeh R., Blakely D., Cook R., Gilbert K., Harrison D.,
RA   Hoang L., Keagle P., Lumm W., Pothier B., Qiu D., Spadafora R., Vicare R.,
RA   Wang Y., Wierzbowski J., Gibson R., Jiwani N., Caruso A., Bush D.,
RA   Safer H., Patwell D., Prabhakar S., McDougall S., Shimer G., Goyal A.,
RA   Pietrovski S., Church G.M., Daniels C.J., Mao J.-I., Rice P., Noelling J.,
RA   Reeve J.N.;
RT   "Complete genome sequence of Methanobacterium thermoautotrophicum deltaH:
RT   functional analysis and comparative genomics.";
RL   J. Bacteriol. 179:7135-7155(1997).
CC   -!- FUNCTION: Probable deacetylase. {ECO:0000250|UniProtKB:Q48935}.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000250|UniProtKB:Q48935};
CC       Note=Binds 1 zinc ion per subunit. {ECO:0000250|UniProtKB:Q48935};
CC   -!- SIMILARITY: Belongs to the histone deacetylase family. {ECO:0000305}.
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DR   EMBL; AE000666; AAB85683.1; -; Genomic_DNA.
DR   PIR; C69026; C69026.
DR   RefSeq; WP_010876818.1; NC_000916.1.
DR   AlphaFoldDB; O27262; -.
DR   SMR; O27262; -.
DR   STRING; 187420.MTH_1194; -.
DR   EnsemblBacteria; AAB85683; AAB85683; MTH_1194.
DR   GeneID; 1471602; -.
DR   KEGG; mth:MTH_1194; -.
DR   PATRIC; fig|187420.15.peg.1172; -.
DR   HOGENOM; CLU_007727_8_0_2; -.
DR   OMA; GRAMGFC; -.
DR   Proteomes; UP000005223; Chromosome.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.800.20; -; 1.
DR   InterPro; IPR000286; His_deacetylse.
DR   InterPro; IPR023801; His_deacetylse_dom.
DR   InterPro; IPR037138; His_deacetylse_dom_sf.
DR   InterPro; IPR023696; Ureohydrolase_dom_sf.
DR   Pfam; PF00850; Hist_deacetyl; 1.
DR   PRINTS; PR01270; HDASUPER.
DR   SUPFAM; SSF52768; SSF52768; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Metal-binding; Reference proteome; Zinc.
FT   CHAIN           1..331
FT                   /note="Probable deacetylase MTH_1194"
FT                   /id="PRO_0000114746"
FT   ACT_SITE        118
FT                   /note="Proton donor/acceptor"
FT                   /evidence="ECO:0000250|UniProtKB:Q48935"
FT   BINDING         155
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250|UniProtKB:Q48935"
FT   BINDING         157
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250|UniProtKB:Q48935"
FT   BINDING         244
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250|UniProtKB:Q48935"
FT   SITE            283
FT                   /note="Polarizes the scissile carbonyl of the substrate"
FT                   /evidence="ECO:0000250|UniProtKB:Q48935"
SQ   SEQUENCE   331 AA;  36722 MW;  489054F32965EDCF CRC64;
     MVIIHSPSYD LHNHEGHVEN SGRTRAILRA IESSDLSPRF VEPGMAGIDD ILMVHSSTHV
     EYLEVFAGRG GGWLDYDTYM TPESFSVARL SAGGAMLAAE EALRDGWSYS LGRPPGHHAT
     YDRSMGFCIF NNIAIAIEHA RRNLGVSRPL VLDFDVHHGN GTSSIFYRDR DVMYISIHQD
     PRTLFPGTGF IDETGSGEGE GFNLNIPMPR GSGNREYLWI LGMILPAVLE GFRPDMIFVS
     AGFDAHRRDP LAEIMVDEEF FSWIGWFIHQ TGLPCTAVLE GGYDPEALGR SNIAFMRGLD
     GEEYEPETAA PGGVSEIFSQ LSDRFSAYFN F