CAPS4_NORAV
ID CAPS4_NORAV Reviewed; 931 AA.
AC Q27YG7;
DT 03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 04-APR-2006, sequence version 1.
DT 02-JUN-2021, entry version 28.
DE RecName: Full=ORF4 polyprotein;
GN ORFNames=ORF4;
OS Nora virus.
OC Viruses; Riboviria; unclassified Riboviria; unclassified ssRNA viruses;
OC unclassified ssRNA positive-strand viruses.
OX NCBI_TaxID=363716;
OH NCBI_TaxID=7227; Drosophila melanogaster (Fruit fly).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX PubMed=16963764; DOI=10.1099/vir.0.81997-0;
RA Habayeb M.S., Ekengren S.K., Hultmark D.;
RT "Nora virus, a persistent virus in Drosophila, defines a new picorna-like
RT virus family.";
RL J. Gen. Virol. 87:3045-3051(2006).
RN [2]
RP FUNCTION, PROTEOLYTIC CLEAVAGE, AND SUBCELLULAR LOCATION.
RX PubMed=27298753; DOI=10.1155/2016/9067848;
RA Ericson B.L., Carlson D.J., Carlson K.A.;
RT "Characterization of Nora virus structural proteins via western blot
RT analysis.";
RL Scientifica (Cairo) 2016:9067848-9067848(2016).
RN [3]
RP STRUCTURE BY ELECTRON MICROSCOPY (2.70 ANGSTROMS).
RA Laurinmaki P., Shakeel S., Ekstrom J.-O., Butcher S.J.;
RT "Uncommon interactions at outer and inner capsid surface stabilize the Nora
RT virus capsid.";
RL Submitted (DEC-2016) to the PDB data bank.
CC -!- FUNCTION: ORF4 polyprotein codes for VP4a, VP4b, and VP4c, three of the
CC four proteins that self-assemble to form the icosahedral capsid. The
CC capsid is made of VP3 (coded by ORF3), VP4a, VP4b and VP4c.
CC {ECO:0000269|PubMed:27298753}.
CC -!- SUBCELLULAR LOCATION: Virion {ECO:0000305|PubMed:27298753}.
CC -!- PTM: Proteolytic processing of ORF4 polyprotein yields the VP4a, VP4b
CC and VP4c capsid proteins. {ECO:0000269|PubMed:27298753}.
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DR EMBL; DQ321720; ABC55270.1; -; Genomic_RNA.
DR PDB; 5MM2; EM; 2.70 A; A=516-931, B=265-515, C=1-264.
DR PDBsum; 5MM2; -.
DR SMR; Q27YG7; -.
DR GO; GO:0019028; C:viral capsid; IDA:UniProtKB.
PE 1: Evidence at protein level;
KW 3D-structure; Capsid protein; Virion.
FT CHAIN 1..931
FT /note="ORF4 polyprotein"
FT /id="PRO_0000283697"
FT HELIX 277..279
FT /evidence="ECO:0007829|PDB:5MM2"
FT STRAND 284..287
FT /evidence="ECO:0007829|PDB:5MM2"
FT HELIX 317..319
FT /evidence="ECO:0007829|PDB:5MM2"
FT STRAND 323..328
FT /evidence="ECO:0007829|PDB:5MM2"
FT STRAND 338..342
FT /evidence="ECO:0007829|PDB:5MM2"
FT STRAND 344..346
FT /evidence="ECO:0007829|PDB:5MM2"
FT STRAND 353..355
FT /evidence="ECO:0007829|PDB:5MM2"
FT HELIX 360..362
FT /evidence="ECO:0007829|PDB:5MM2"
FT STRAND 363..368
FT /evidence="ECO:0007829|PDB:5MM2"
FT STRAND 372..375
FT /evidence="ECO:0007829|PDB:5MM2"
FT STRAND 380..384
FT /evidence="ECO:0007829|PDB:5MM2"
FT STRAND 391..403
FT /evidence="ECO:0007829|PDB:5MM2"
FT STRAND 406..410
FT /evidence="ECO:0007829|PDB:5MM2"
FT STRAND 414..418
FT /evidence="ECO:0007829|PDB:5MM2"
FT HELIX 435..438
FT /evidence="ECO:0007829|PDB:5MM2"
FT STRAND 449..460
FT /evidence="ECO:0007829|PDB:5MM2"
FT STRAND 468..472
FT /evidence="ECO:0007829|PDB:5MM2"
FT HELIX 496..498
FT /evidence="ECO:0007829|PDB:5MM2"
FT TURN 499..501
FT /evidence="ECO:0007829|PDB:5MM2"
FT TURN 528..530
FT /evidence="ECO:0007829|PDB:5MM2"
FT STRAND 548..551
FT /evidence="ECO:0007829|PDB:5MM2"
FT HELIX 556..559
FT /evidence="ECO:0007829|PDB:5MM2"
FT STRAND 562..569
FT /evidence="ECO:0007829|PDB:5MM2"
FT STRAND 575..578
FT /evidence="ECO:0007829|PDB:5MM2"
FT HELIX 597..602
FT /evidence="ECO:0007829|PDB:5MM2"
FT STRAND 603..611
FT /evidence="ECO:0007829|PDB:5MM2"
FT STRAND 613..624
FT /evidence="ECO:0007829|PDB:5MM2"
FT STRAND 635..640
FT /evidence="ECO:0007829|PDB:5MM2"
FT STRAND 642..644
FT /evidence="ECO:0007829|PDB:5MM2"
FT HELIX 646..652
FT /evidence="ECO:0007829|PDB:5MM2"
FT HELIX 658..660
FT /evidence="ECO:0007829|PDB:5MM2"
FT STRAND 665..667
FT /evidence="ECO:0007829|PDB:5MM2"
FT STRAND 698..702
FT /evidence="ECO:0007829|PDB:5MM2"
FT STRAND 707..709
FT /evidence="ECO:0007829|PDB:5MM2"
FT HELIX 715..717
FT /evidence="ECO:0007829|PDB:5MM2"
FT TURN 721..723
FT /evidence="ECO:0007829|PDB:5MM2"
FT STRAND 727..732
FT /evidence="ECO:0007829|PDB:5MM2"
FT STRAND 744..746
FT /evidence="ECO:0007829|PDB:5MM2"
FT TURN 747..749
FT /evidence="ECO:0007829|PDB:5MM2"
FT STRAND 755..760
FT /evidence="ECO:0007829|PDB:5MM2"
FT STRAND 774..781
FT /evidence="ECO:0007829|PDB:5MM2"
FT STRAND 784..790
FT /evidence="ECO:0007829|PDB:5MM2"
FT STRAND 802..804
FT /evidence="ECO:0007829|PDB:5MM2"
FT STRAND 809..811
FT /evidence="ECO:0007829|PDB:5MM2"
FT HELIX 812..814
FT /evidence="ECO:0007829|PDB:5MM2"
FT HELIX 815..823
FT /evidence="ECO:0007829|PDB:5MM2"
FT TURN 827..829
FT /evidence="ECO:0007829|PDB:5MM2"
FT HELIX 834..846
FT /evidence="ECO:0007829|PDB:5MM2"
FT STRAND 851..856
FT /evidence="ECO:0007829|PDB:5MM2"
FT HELIX 857..860
FT /evidence="ECO:0007829|PDB:5MM2"
FT HELIX 870..874
FT /evidence="ECO:0007829|PDB:5MM2"
FT TURN 875..878
FT /evidence="ECO:0007829|PDB:5MM2"
SQ SEQUENCE 931 AA; 102290 MW; DB527CEDD7B3E13E CRC64;
MQNPTQTMHI YDMPLRVIAG LSTLAKTTEE DDNTSTGIVV SEVGEPQVVN HPAWIDPFVA
YQLRAPRKNI TPDFIFGRAD IGNAFSAFLP RRFSAPAVGT RLVVDPVFTY QQRTVLGLYN
YFHADFYYIV HVPAPLGTGI YLKIYAPEFD TTTVTRGIRF KPSASPTIAL SVPWSNDLST
VETSVGRVGQ SGGSIVIETI EDNSNETVNT PLSITVWCCM ANIKATGYRH ADTSAYNEKG
MNFISVPVPK PPVPPTKPIT GEEQADNEVT AEGGKLVQEL VYDHSAIPVA PVVETQAEQP
EVPVSLVATR KNDTGHLATK WYDFAKISLS NPANMNWTTL TIDPYNNVTL SRDGESMVLP
WRRNVWTTGS KSIGYIRTMV AQINIPRPPQ ISGVLEVKDS INNSSISLVE FGGKVEIPII
PKVMNGLATT ASLPRHRLNP WMRTAESKVE LQYRIIAFNR TSDIADLNVS VLLRPGDSQF
QLPMKPDNNV DTRHFELVEA LMYHYDSLRI RGEEQSLPEN APNAVSNPQQ FITPATALSA
EEYNVHEALG ETEELELDEF PVLVFKGNVP VDSVTSIPLD LATIYDFAWD GEQNAISQKF
QRFAHLIPKS AGGFGPVIGN YTITANLPTG VAGRILHNCL PGDCVDLAVS RIFGLKSLLG
VAGTAVSAIG GPLLNGLVNT AAPILSGAAH AIGGNVVGGL ADAVIDIGSN LLTPKEKEQP
SANSSAISGD IPISRFVEML KYVKENYQDN PVFPTLLVEP QNFISNAMTA LKTIPIEVFA
NMRNVKVERN LFDRTVVPTV KEATLADIVI PNHMYGYILR DFLQNKRAFQ SGTKQNVYFQ
QFLTVLSQRN IRTHITLNDI TSCSIDSESI ANKIERVKHY LSTNSSGETT EEFSRTDTGL
LPTTTRKIVL GESKRRTERY VAETVFPSVR Q
