ID   Y120_METTH              Reviewed;         191 AA.
AC   O26223;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=Putative NADH dehydrogenase/NAD(P)H nitroreductase;
DE            EC=1.-.-.-;
GN   OrderedLocusNames=MTH_120;
OS   Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM
OS   10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum).
OC   Archaea; Euryarchaeota; Methanomada group; Methanobacteria;
OC   Methanobacteriales; Methanobacteriaceae; Methanothermobacter.
OX   NCBI_TaxID=187420;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H;
RX   PubMed=9371463; DOI=10.1128/jb.179.22.7135-7155.1997;
RA   Smith D.R., Doucette-Stamm L.A., Deloughery C., Lee H.-M., Dubois J.,
RA   Aldredge T., Bashirzadeh R., Blakely D., Cook R., Gilbert K., Harrison D.,
RA   Hoang L., Keagle P., Lumm W., Pothier B., Qiu D., Spadafora R., Vicare R.,
RA   Wang Y., Wierzbowski J., Gibson R., Jiwani N., Caruso A., Bush D.,
RA   Safer H., Patwell D., Prabhakar S., McDougall S., Shimer G., Goyal A.,
RA   Pietrovski S., Church G.M., Daniels C.J., Mao J.-I., Rice P., Noelling J.,
RA   Reeve J.N.;
RT   "Complete genome sequence of Methanobacterium thermoautotrophicum deltaH:
RT   functional analysis and comparative genomics.";
RL   J. Bacteriol. 179:7135-7155(1997).
CC   -!- COFACTOR:
CC       Name=FMN; Xref=ChEBI:CHEBI:58210; Evidence={ECO:0000305};
CC   -!- SIMILARITY: Belongs to the nitroreductase family. {ECO:0000305}.
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DR   EMBL; AE000666; AAB84626.1; -; Genomic_DNA.
DR   PIR; B69027; B69027.
DR   AlphaFoldDB; O26223; -.
DR   SMR; O26223; -.
DR   STRING; 187420.MTH_120; -.
DR   EnsemblBacteria; AAB84626; AAB84626; MTH_120.
DR   KEGG; mth:MTH_120; -.
DR   PATRIC; fig|187420.15.peg.93; -.
DR   HOGENOM; CLU_070764_7_3_2; -.
DR   OMA; HPYAKML; -.
DR   Proteomes; UP000005223; Chromosome.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.109.10; -; 1.
DR   InterPro; IPR029479; Nitroreductase.
DR   InterPro; IPR000415; Nitroreductase-like.
DR   Pfam; PF00881; Nitroreductase; 2.
DR   SUPFAM; SSF55469; SSF55469; 1.
PE   3: Inferred from homology;
KW   Flavoprotein; FMN; NAD; NADP; Oxidoreductase; Reference proteome.
FT   CHAIN           1..191
FT                   /note="Putative NADH dehydrogenase/NAD(P)H nitroreductase"
FT                   /id="PRO_0000072725"
FT   BINDING         127..132
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   191 AA;  21687 MW;  FAB253F75DAD84BB CRC64;
     MKLLWTSQHI KVTVHIDGKV SKMDVLEAIK TRRSIRKYQD REVPEELIDK ILDAAMCGPS
     AVDERPWHFI VVRNREMLEK IPEVHPYGAM VKDAPVAIIV CCDSSLEKIP GFWVQDCSIA
     SQNILLAAHS LGLGAVWTGV YPLEDRVEGI RRLFSIPEHV IPFSVIPLGY PAENPGTRDL
     FDPDRIHLEK W