ID   CAPSD_AEDEV             Reviewed;         358 AA.
AC   P27453;
DT   01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1992, sequence version 1.
DT   02-JUN-2021, entry version 61.
DE   RecName: Full=Capsid protein VP1/VP2;
DE   AltName: Full=Coat protein VP1/VP2;
GN   Name=VP;
OS   Aedes densonucleosis virus (strain GKV 002 002) (Aedes densovirus).
OC   Viruses; Monodnaviria; Shotokuvirae; Cossaviricota; Quintoviricetes;
OC   Piccovirales; Parvoviridae; Hamaparvovirinae; Brevihamaparvovirus;
OC   Dipteran brevihamaparvovirus 1.
OX   NCBI_TaxID=10808;
OH   NCBI_TaxID=7158; Aedes.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1833875; DOI=10.1016/0042-6822(91)90780-f;
RA   Afanasiev B.N., Galyov E.E., Buchatsky L.P., Kozlov Y.V.;
RT   "Nucleotide sequence and genomic organization of Aedes densonucleosis
RT   virus.";
RL   Virology 185:323-336(1991).
CC   -!- FUNCTION: Capsid protein self-assembles to form an icosahedral capsid
CC       with a T=1 symmetry, about 22 nm in diameter, and consisting of 60
CC       copies of size variants of the capsid proteins, which differ in the N-
CC       terminushe capsid encapsulates the genomic ssDNA. Capsid proteins are
CC       responsible for the attachment to host cell receptors. This attachment
CC       induces virion internalization predominantly through clathrin-dependent
CC       endocytosis (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative initiation; Named isoforms=2;
CC       Name=VP1;
CC         IsoId=P27453-1; Sequence=Displayed;
CC       Name=VP2;
CC         IsoId=P27453-2; Sequence=Not described;
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DR   EMBL; M37899; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   PIR; D40784; VCPVAD.
DR   Proteomes; UP000008473; Genome.
DR   GO; GO:0039615; C:T=1 icosahedral viral capsid; IEA:UniProtKB-KW.
DR   GO; GO:0075512; P:clathrin-dependent endocytosis of virus by host cell; IEA:UniProtKB-KW.
DR   GO; GO:0039665; P:permeabilization of host organelle membrane involved in viral entry into host cell; IEA:UniProtKB-KW.
DR   GO; GO:0099008; P:viral entry via permeabilization of inner membrane; IEA:UniProtKB-KW.
DR   GO; GO:0019062; P:virion attachment to host cell; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Alternative initiation; Capsid protein;
KW   Clathrin-mediated endocytosis of virus by host; Host-virus interaction;
KW   T=1 icosahedral capsid protein; Viral attachment to host cell;
KW   Viral penetration into host cytoplasm;
KW   Viral penetration via permeabilization of host membrane; Virion;
KW   Virus endocytosis by host; Virus entry into host cell.
FT   CHAIN           1..358
FT                   /note="Capsid protein VP1/VP2"
FT                   /id="PRO_0000039445"
FT   REGION          1..37
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..21
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   358 AA;  40508 MW;  9DB7681D0E0813D0 CRC64;
     MADSTSMDHD GEQRGTKRKR DAGAGGSGAG IGKGTSNYVK EGYGPNMSEM VPRNIMNKGN
     HTVYHVVKQQ KYLDFNYVSN QNPYIIPYQT AGFWASMWDQ TDIGSNNTIN IMKALNNVSV
     GVTWIKGEIT FEVYAVTRQR LLTGTTNQTT WDFETSQNMF IADADREPEN FNLATAAATG
     PLAQQTTQTL LFNANNDRYT KYELPQRNQY TREYDFQQLT NNYMWKPTDI SAAANFRRLI
     PMAEGVYTTT AATTKMAELT EQKSVYAGSG KTTEASLFRN RTSYPRMHMA QPQVPDETGY
     MKFRYQVRMS TKLHLVFHLY PDYSTSTNIE YMGRQVLELP EVTATGGVVT CMPYEIKT