ID   CAPSD_AHEV              Reviewed;         606 AA.
AC   Q913Y7;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   03-AUG-2022, entry version 59.
DE   RecName: Full=Capsid protein;
DE   AltName: Full=Protein ORF2;
DE            Short=pORF2;
DE   Flags: Precursor;
GN   ORFNames=ORF2;
OS   Avian hepatitis E virus (isolate Chicken/California/Meng) (AHEV).
OC   Viruses; Riboviria; Orthornavirae; Kitrinoviricota; Alsuviricetes;
OC   Hepelivirales; Hepeviridae; Orthohepevirus.
OX   NCBI_TaxID=516993;
OH   NCBI_TaxID=9031; Gallus gallus (Chicken).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=11562538; DOI=10.1099/0022-1317-82-10-2449;
RA   Haqshenas G., Shivaprasad H.L., Woolcock P.R., Read D.H., Meng X.J.;
RT   "Genetic identification and characterization of a novel virus related to
RT   human hepatitis E virus from chickens with hepatitis-splenomegaly syndrome
RT   in the United States.";
RL   J. Gen. Virol. 82:2449-2462(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=15166445; DOI=10.1099/vir.0.79841-0;
RA   Huang F.F., Sun Z.F., Emerson S.U., Purcell R.H., Shivaprasad H.L.,
RA   Pierson F.W., Toth T.E., Meng X.J.;
RT   "Determination and analysis of the complete genomic sequence of avian
RT   hepatitis E virus (avian HEV) and attempts to infect rhesus monkeys with
RT   avian HEV.";
RL   J. Gen. Virol. 85:1609-1618(2004).
CC   -!- FUNCTION: Major viral capsid protein that encapsidates the viral
CC       genome. Binds to the 5' end of the genomic RNA (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Self-assembles to form the capsid. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000305}. Host cytoplasm
CC       {ECO:0000250}. Host cell surface {ECO:0000250}. Note=Initially
CC       cotranslationally translocated into the ER from where it is
CC       retrotranslocated to the cytoplasm. A fraction is also observed on the
CC       cell surface (By similarity). {ECO:0000250}.
CC   -!- PTM: In vivo, the glycosylated form is probably much less stable than
CC       the non-glycosylated form, which is present in the cytosol and
CC       represents the major product accumulated in the cell. May be present
CC       initially as a glycosylated protein in the ER, and may become
CC       unglycosylated and retrotranslocated to the cytoplasm by the
CC       endoplasmic reticulum-associated degradation (ERAD) system. The non-
CC       glycosylated form may therefore be the authentic intermediate in HEV
CC       capsid assembly (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the hepevirus capsid protein family.
CC       {ECO:0000305}.
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DR   EMBL; AY043166; AAL13367.1; -; Genomic_RNA.
DR   EMBL; AY535004; AAS45831.1; -; Genomic_RNA.
DR   RefSeq; YP_009001467.1; NC_023425.1.
DR   SMR; Q913Y7; -.
DR   GeneID; 18263428; -.
DR   KEGG; vg:18263428; -.
DR   Proteomes; UP000007439; Genome.
DR   Proteomes; UP000139094; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0044228; C:host cell surface; IEA:UniProtKB-SubCell.
DR   GO; GO:0039615; C:T=1 icosahedral viral capsid; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   Gene3D; 2.60.120.20; -; 1.
DR   InterPro; IPR004261; SP2.
DR   InterPro; IPR029053; Viral_coat.
DR   Pfam; PF03014; SP2; 1.
PE   3: Inferred from homology;
KW   Capsid protein; Host cytoplasm; RNA-binding; Signal;
KW   T=1 icosahedral capsid protein; Virion.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..606
FT                   /note="Capsid protein"
FT                   /id="PRO_0000334533"
FT   REGION          22..54
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          313..339
FT                   /note="particle formation"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   606 AA;  65005 MW;  8DCB8111A91F31C3 CRC64;
     MSLCRLLLML AMCCGVSRGS QTLPAGGRRG QRRRDNSAQW STQQRPEGAV GPAPLTDVVT
     AAGTRTVPDV DQAGAVLVRQ YNLVTSPLGL ATLGSTNALL YAAPVSPLMP LQDGTTSNIM
     STESSNYAQY RVQGLTVRWR PVVPNAVGGF SISMAYWPQT TSTPTSIDMN SITSTDVRVV
     LQPGSAGLLT IPHERLAYKN NGWRSVETVS VPQEDATSGM LMVCVHGTPW NSYTNSVYTG
     PLGMVDFAIK LQLRNLSPGN TNARVTRVKV TAPHTIKADP SGATITTAAA ARFMADVRWG
     LGTAEDGEIG HGILGVLFNL ADTVLGGLPS TLLRAASGQY MYGRPVGNAN GEPEVKLYMS
     VEDAVNDKPI MVPHDIDLGT STVTCQDYGN QHVDDRPSPA PAPKRALGTL RSGDVLRITG
     SMQYVTNAEL LPQSVSQGYF GAGSTMMVHN LITGVRAPAS SVDWTKATVD GVQVKTVDAS
     SGSNRFAALP AFGKPAVWGP QGAGYFYQYN STHQEWIYFL QNGSSVVWYA YTNMLGQKSD
     TSILFEVRPI QASDQPWFLA HHTGGDDCTT CLPLGLRTCC RQAPEDQSPE TRRLLDRLSR
     TFPSPP