ID   Y1218_HAEIN             Reviewed;         532 AA.
AC   Q57251;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 104.
DE   RecName: Full=Putative L-lactate permease;
GN   OrderedLocusNames=HI_1218;
OS   Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=71421;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=7542800; DOI=10.1126/science.7542800;
RA   Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA   Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA   McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA   Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA   Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA   Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA   Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA   Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT   "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT   Rd.";
RL   Science 269:496-512(1995).
CC   -!- FUNCTION: May play a role in L-lactate transport.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the lactate permease family. {ECO:0000305}.
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DR   EMBL; L42023; AAC22871.1; -; Genomic_DNA.
DR   PIR; H64110; H64110.
DR   RefSeq; NP_439374.1; NC_000907.1.
DR   AlphaFoldDB; Q57251; -.
DR   STRING; 71421.HI_1218; -.
DR   TCDB; 2.A.14.2.1; the lactate permease (lctp) family.
DR   EnsemblBacteria; AAC22871; AAC22871; HI_1218.
DR   KEGG; hin:HI_1218; -.
DR   PATRIC; fig|71421.8.peg.1270; -.
DR   eggNOG; COG1620; Bacteria.
DR   HOGENOM; CLU_021628_4_1_6; -.
DR   OMA; LIVTRIH; -.
DR   PhylomeDB; Q57251; -.
DR   BioCyc; HINF71421:G1GJ1-1249-MON; -.
DR   Proteomes; UP000000579; Chromosome.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:InterPro.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0015129; F:lactate transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0015295; F:solute:proton symporter activity; IBA:GO_Central.
DR   InterPro; IPR003804; Lactate_perm.
DR   PANTHER; PTHR30003; PTHR30003; 1.
DR   Pfam; PF02652; Lactate_perm; 1.
DR   TIGRFAMs; TIGR00795; lctP; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..532
FT                   /note="Putative L-lactate permease"
FT                   /id="PRO_0000210382"
FT   TRANSMEM        23..43
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        56..76
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        101..121
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        129..149
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        152..172
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        180..200
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        213..233
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        234..254
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        274..294
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        346..366
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        387..407
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        420..440
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        462..482
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        508..528
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   532 AA;  56885 MW;  F3C1DF47E54217FB CRC64;
     MLSFILSIFP IVLLIYLMVK RNALPSYVAL PWVATLVMGV HLLHFNTDIV TISANVVSAI
     IAVQTPITVI FGAILFNRFS EISGATNIMR KWLGNINPNP VAQLMIIGWA FAFMIEGASG
     FGTPAAIAAP ILVGLGFHPL KVAMLALIMN SVPVSFGAVG TPTWFGFGAL KLSEDMILEI
     GSITAFIHSI AALIIPLLAL RILVNWDDIR KNIVFIYISV LGCVVPYFLI AQVNYEFPSL
     VGGAIGLFIS VWAANRNIGL AKVTNTLDNN AVSAGEVVKA LFPTGLLIAF LIVTRIHQLP
     FKAMMNDATI WFSTTLGSLG LFEISKGLIF SLKNIFGSNV SSSYKLLYVP ALIPFVITVL
     IAIPFFKISS SNVKQILVSS LQQSKNPFIA LIGALVMVNL MLVGGEHSMV KIIGRTFAEI
     SGSNWTIFSS FLGAIGSFFS GSNTVSNLTF GSVQLSTAET TGISVALVLA LQSVGGAMGN
     MVCINNIVAV SSVLNISNQE GTIIKKTIIP MIIYGIIAAL GALFLVPLFY NL