ID   Y1222_MYCLE             Reviewed;         198 AA.
AC   Q49626;
DT   29-AUG-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 94.
DE   RecName: Full=Uncharacterized protein ML1222;
GN   OrderedLocusNames=ML1222; ORFNames=B1170_C3_229;
OS   Mycobacterium leprae (strain TN).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium.
OX   NCBI_TaxID=272631;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Smith D.R., Robison K.;
RL   Submitted (MAR-1994) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TN;
RX   PubMed=11234002; DOI=10.1038/35059006;
RA   Cole S.T., Eiglmeier K., Parkhill J., James K.D., Thomson N.R.,
RA   Wheeler P.R., Honore N., Garnier T., Churcher C.M., Harris D.E.,
RA   Mungall K.L., Basham D., Brown D., Chillingworth T., Connor R.,
RA   Davies R.M., Devlin K., Duthoy S., Feltwell T., Fraser A., Hamlin N.,
RA   Holroyd S., Hornsby T., Jagels K., Lacroix C., Maclean J., Moule S.,
RA   Murphy L.D., Oliver K., Quail M.A., Rajandream M.A., Rutherford K.M.,
RA   Rutter S., Seeger K., Simon S., Simmonds M., Skelton J., Squares R.,
RA   Squares S., Stevens K., Taylor K., Whitehead S., Woodward J.R.,
RA   Barrell B.G.;
RT   "Massive gene decay in the leprosy bacillus.";
RL   Nature 409:1007-1011(2001).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: To M.tuberculosis Rv1591. {ECO:0000305}.
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DR   EMBL; U00010; AAA17073.1; -; Genomic_DNA.
DR   EMBL; AL583921; CAC31603.1; -; Genomic_DNA.
DR   PIR; S72709; S72709.
DR   RefSeq; NP_301885.1; NC_002677.1.
DR   RefSeq; WP_010908206.1; NC_002677.1.
DR   AlphaFoldDB; Q49626; -.
DR   STRING; 272631.ML1222; -.
DR   EnsemblBacteria; CAC31603; CAC31603; CAC31603.
DR   KEGG; mle:ML1222; -.
DR   PATRIC; fig|272631.5.peg.2242; -.
DR   Leproma; ML1222; -.
DR   eggNOG; ENOG50325BP; Bacteria.
DR   HOGENOM; CLU_102917_0_0_11; -.
DR   OMA; RVHDYLG; -.
DR   Proteomes; UP000000806; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR021213; DUF2567.
DR   Pfam; PF10821; DUF2567; 1.
PE   4: Predicted;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..198
FT                   /note="Uncharacterized protein ML1222"
FT                   /id="PRO_0000103893"
FT   TRANSMEM        20..40
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        70..90
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        107..127
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        164..184
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   198 AA;  20633 MW;  65B0422C4B584EBE CRC64;
     MTEHCASDIS DVSCPPRGRV IVGVVLGLAG TGALIGGLWA WIAPPIHAVV GLTRTGERGH
     DYLGNESEHF FVAPCLMLGL LTVLAVTASV LAWQLRQHRG PGMVIGLAIG LMICAATAAA
     VGALLVWMRY GALNFDAVPL SYDHKVAHVI QAPPVFFAHG LLQVAATVLW PAGIAALVYA
     VLAAANGRDD LGGRLCSR