ID   Y1222_PYRFU             Reviewed;          78 AA.
AC   Q8U1I5;
DT   31-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT   31-AUG-2004, sequence version 2.
DT   25-MAY-2022, entry version 75.
DE   RecName: Full=Putative antitoxin PF1222 {ECO:0000255|HAMAP-Rule:MF_00794};
GN   OrderedLocusNames=PF1222;
OS   Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1).
OC   Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC   Pyrococcus.
OX   NCBI_TaxID=186497;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43587 / DSM 3638 / JCM 8422 / Vc1;
RX   PubMed=10430560; DOI=10.1093/genetics/152.4.1299;
RA   Maeder D.L., Weiss R.B., Dunn D.M., Cherry J.L., Gonzalez J.M.,
RA   DiRuggiero J., Robb F.T.;
RT   "Divergence of the hyperthermophilic archaea Pyrococcus furiosus and P.
RT   horikoshii inferred from complete genomic sequences.";
RL   Genetics 152:1299-1305(1999).
CC   -!- FUNCTION: Possibly the antitoxin component of a type II toxin-antitoxin
CC       (TA) system. {ECO:0000255|HAMAP-Rule:MF_00794}.
CC   -!- SIMILARITY: Belongs to the UPF0330 family. {ECO:0000255|HAMAP-
CC       Rule:MF_00794}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAL81346.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AE009950; AAL81346.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_014835359.1; NZ_CP023154.1.
DR   AlphaFoldDB; Q8U1I5; -.
DR   SMR; Q8U1I5; -.
DR   STRING; 186497.PF1222; -.
DR   EnsemblBacteria; AAL81346; AAL81346; PF1222.
DR   GeneID; 41713029; -.
DR   KEGG; pfu:PF1222; -.
DR   PATRIC; fig|186497.12.peg.1285; -.
DR   eggNOG; arCOG02681; Archaea.
DR   HOGENOM; CLU_170073_3_0_2; -.
DR   OMA; AYMKTIM; -.
DR   OrthoDB; 124152at2157; -.
DR   PhylomeDB; Q8U1I5; -.
DR   Proteomes; UP000001013; Chromosome.
DR   HAMAP; MF_00794; UPF0330; 1.
DR   InterPro; IPR003847; Put_antitoxin.
DR   Pfam; PF02697; VAPB_antitox; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Toxin-antitoxin system.
FT   CHAIN           1..78
FT                   /note="Putative antitoxin PF1222"
FT                   /id="PRO_0000157112"
SQ   SEQUENCE   78 AA;  9350 MW;  5CBEC86F7493E72A CRC64;
     MVKTITISDD VYNELLRIKG NKSFSEVLRE LLKERKGNKE VLKRIFGILS EEEYQEVKKR
     LKELEGEFEK WEQSLTQM