Y1226_METJA
ID Y1226_METJA Reviewed; 805 AA.
AC Q58623;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 25-MAY-2022, entry version 136.
DE RecName: Full=Putative cation-transporting ATPase MJ1226;
DE EC=7.2.2.-;
GN OrderedLocusNames=MJ1226;
OS Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM
OS 10045 / NBRC 100440) (Methanococcus jannaschii).
OC Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC Methanocaldococcaceae; Methanocaldococcus.
OX NCBI_TaxID=243232;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440;
RX PubMed=8688087; DOI=10.1126/science.273.5278.1058;
RA Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D., Sutton G.G.,
RA Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D., Kerlavage A.R.,
RA Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I., Overbeek R.,
RA Kirkness E.F., Weinstock K.G., Merrick J.M., Glodek A., Scott J.L.,
RA Geoghagen N.S.M., Weidman J.F., Fuhrmann J.L., Nguyen D., Utterback T.R.,
RA Kelley J.M., Peterson J.D., Sadow P.W., Hanna M.C., Cotton M.D.,
RA Roberts K.M., Hurst M.A., Kaine B.P., Borodovsky M., Klenk H.-P.,
RA Fraser C.M., Smith H.O., Woese C.R., Venter J.C.;
RT "Complete genome sequence of the methanogenic archaeon, Methanococcus
RT jannaschii.";
RL Science 273:1058-1073(1996).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216;
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the cation transport ATPase (P-type) (TC 3.A.3)
CC family. Type IIIA subfamily. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; L77117; AAB99229.1; -; Genomic_DNA.
DR PIR; A64453; A64453.
DR AlphaFoldDB; Q58623; -.
DR SMR; Q58623; -.
DR STRING; 243232.MJ_1226; -.
DR TCDB; 3.A.3.3.4; the p-type atpase (p-atpase) superfamily.
DR PRIDE; Q58623; -.
DR EnsemblBacteria; AAB99229; AAB99229; MJ_1226.
DR KEGG; mja:MJ_1226; -.
DR eggNOG; arCOG01578; Archaea.
DR HOGENOM; CLU_002360_6_4_2; -.
DR InParanoid; Q58623; -.
DR OMA; GVDINWM; -.
DR PhylomeDB; Q58623; -.
DR Proteomes; UP000000805; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0015662; F:P-type ion transporter activity; IBA:GO_Central.
DR GO; GO:0008553; F:P-type proton-exporting transporter activity; IEA:InterPro.
DR GO; GO:0034220; P:ion transmembrane transport; IBA:GO_Central.
DR GO; GO:0120029; P:proton export across plasma membrane; IEA:InterPro.
DR CDD; cd02076; P-type_ATPase_H; 1.
DR Gene3D; 3.40.1110.10; -; 1.
DR Gene3D; 3.40.50.1000; -; 1.
DR InterPro; IPR004014; ATPase_P-typ_cation-transptr_N.
DR InterPro; IPR023299; ATPase_P-typ_cyto_dom_N.
DR InterPro; IPR018303; ATPase_P-typ_P_site.
DR InterPro; IPR023298; ATPase_P-typ_TM_dom_sf.
DR InterPro; IPR008250; ATPase_P-typ_transduc_dom_A_sf.
DR InterPro; IPR036412; HAD-like_sf.
DR InterPro; IPR023214; HAD_sf.
DR InterPro; IPR006534; P-type_ATPase_IIIA.
DR InterPro; IPR001757; P_typ_ATPase.
DR InterPro; IPR044492; P_typ_ATPase_HD_dom.
DR Pfam; PF00690; Cation_ATPase_N; 1.
DR PRINTS; PR00120; HATPASE.
DR SFLD; SFLDF00027; p-type_atpase; 1.
DR SMART; SM00831; Cation_ATPase_N; 1.
DR SUPFAM; SSF56784; SSF56784; 1.
DR SUPFAM; SSF81653; SSF81653; 1.
DR SUPFAM; SSF81660; SSF81660; 1.
DR SUPFAM; SSF81665; SSF81665; 1.
DR TIGRFAMs; TIGR01647; ATPase-IIIA_H; 1.
DR TIGRFAMs; TIGR01494; ATPase_P-type; 2.
DR PROSITE; PS00154; ATPASE_E1_E2; 1.
PE 3: Inferred from homology;
KW ATP-binding; Cell membrane; Membrane; Nucleotide-binding; Phosphoprotein;
KW Reference proteome; Translocase; Transmembrane; Transmembrane helix.
FT CHAIN 1..805
FT /note="Putative cation-transporting ATPase MJ1226"
FT /id="PRO_0000046427"
FT TRANSMEM 53..73
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 75..95
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 226..246
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 258..278
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 615..637
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 641..663
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 680..700
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 712..734
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 747..769
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 773..790
FT /note="Helical"
FT /evidence="ECO:0000255"
FT ACT_SITE 311
FT /note="4-aspartylphosphate intermediate"
FT /evidence="ECO:0000250"
SQ SEQUENCE 805 AA; 89618 MW; 8E63D3F7E47668CD CRC64;
MWGVVMNVEE IEEEYKTSIK TGLSTEEAKK RLKIYGYNEI PEKKVHPIIK FLSYFWNPIA
WMIEIAAILS AIIKHWVDFV IILILLLVNG VVGFWEEYKA ENVIEFLKQK MALNARVLRD
GKWQIIPAKE LVPGDVVRIR IGDIVPADII LVDGDYLVVD ESALTGESLP VEKKIGDIAY
SGSIVKKGEM TGIVKATGLN TYFGKTVKLV EKAEKVSSYQ KMIIKIGDYL IVLAVILIAI
MVAVELFRGK SLIETAQFAL VLAVSAIPAA MPAVLSITMA IGALNLAKKD AIVKKLVAIE
ELAGVDILCS DKTGTLTKNQ LVCGEIIALN GFSKEDVVLF AALASREEDA DAIDMAILNE
AKKLGLMEKI KNYKIKKFIP FDPVIKRTEA EVTNDEEFKV SKGAPQVILD LCNADEELRR
KVEEIVDKLA ENGYRALGVA VYKNGRWHFA GIIPLYDPPR EDAPLAVKKI KELGVIIKMV
TGDHVAIAKN IARMLGIGDK IISISELLKK LKRGEIKEEK FDEIVEEADG FAEVFPEHKY
KIVDSLQKRG HLVAMTGDGV NDAPALKKAD CGIAVSNATD AARAAADIVL LSPGISVIVD
AIQEARRIFQ RMESYVIYRI TETIRILFFV ELCILILGIY PITALMIVLL AILNDIPILA
IAYDNVVEPK SPVRWRMREI LMLSTALGLS GVVSSFLIFY ISDVFLHLTI AELQSFVFLK
LILAGHATIF VTRIRDRLWK KPYPSKLLFW GVMGTNIIGT IVAAEGIFMA PIGWDLALFM
WLYAHVWMLI NDEIKMILLK RLKID
