Y1234_HELPY
ID Y1234_HELPY Reviewed; 298 AA.
AC O25832;
DT 15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 25-MAY-2022, entry version 110.
DE RecName: Full=Uncharacterized transporter HP_1234;
GN OrderedLocusNames=HP_1234;
OS Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori).
OC Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC Helicobacteraceae; Helicobacter.
OX NCBI_TaxID=85962;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700392 / 26695;
RX PubMed=9252185; DOI=10.1038/41483;
RA Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G.,
RA Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A.,
RA Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N.,
RA Loftus B.J., Richardson D.L., Dodson R.J., Khalak H.G., Glodek A.,
RA McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E.,
RA Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D.,
RA Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S.,
RA Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C.;
RT "The complete genome sequence of the gastric pathogen Helicobacter
RT pylori.";
RL Nature 388:539-547(1997).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the EamA transporter family. {ECO:0000305}.
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DR EMBL; AE000511; AAD08277.1; -; Genomic_DNA.
DR PIR; B64674; B64674.
DR RefSeq; NP_208026.1; NC_000915.1.
DR RefSeq; WP_001246343.1; NC_018939.1.
DR AlphaFoldDB; O25832; -.
DR SMR; O25832; -.
DR DIP; DIP-3419N; -.
DR IntAct; O25832; 1.
DR MINT; O25832; -.
DR STRING; 85962.C694_06370; -.
DR TCDB; 2.A.7.28.9; the drug/metabolite transporter (dmt) superfamily.
DR PaxDb; O25832; -.
DR EnsemblBacteria; AAD08277; AAD08277; HP_1234.
DR KEGG; hpy:HP_1234; -.
DR PATRIC; fig|85962.47.peg.1322; -.
DR eggNOG; COG0697; Bacteria.
DR OMA; MGVCVKL; -.
DR PhylomeDB; O25832; -.
DR Proteomes; UP000000429; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR000620; EamA_dom.
DR Pfam; PF00892; EamA; 2.
PE 3: Inferred from homology;
KW Cell membrane; Membrane; Reference proteome; Repeat; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..298
FT /note="Uncharacterized transporter HP_1234"
FT /id="PRO_0000108193"
FT TRANSMEM 5..25
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 36..56
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 76..96
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 97..117
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 124..144
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 147..167
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 181..201
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 216..236
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 244..264
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..292
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 17..141
FT /note="EamA 1"
FT DOMAIN 183..288
FT /note="EamA 2"
SQ SEQUENCE 298 AA; 32885 MW; DD1853F4BE9A5E18 CRC64;
MRNTILFGVS MILLANLCFG IMSAFVKITA DYFSPMENVF YRSITMTLLL LLIYPFKPYR
LKSYKQGGFK KLAFRVVVGG LAMLAFFYNI EKISLATATA FSQCAPIYTV LLSPLLLKEK
LKRSTLISAC IGIVGVVLIS DPSVENVGPV EIFMGILSGI FVSLAYITLR DLREYYDKQA
VILAFAFGMS LLGLVGMFID IPFLSTGIHV PRKEDILWIS LIGISGTLGQ YFLTYAYMNA
PAGIIAPIEY TRIVWGLLFG LYLGDTFLDL KSSLGVALIL CSGLLIALPA LLKELKKI
