ID   Y123_TREPA              Reviewed;         856 AA.
AC   O83160;
DT   01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   25-MAY-2022, entry version 93.
DE   RecName: Full=TPR repeat-containing protein TP_0123;
GN   OrderedLocusNames=TP_0123;
OS   Treponema pallidum (strain Nichols).
OC   Bacteria; Spirochaetes; Spirochaetales; Treponemataceae; Treponema.
OX   NCBI_TaxID=243276;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Nichols;
RX   PubMed=9665876; DOI=10.1126/science.281.5375.375;
RA   Fraser C.M., Norris S.J., Weinstock G.M., White O., Sutton G.G.,
RA   Dodson R.J., Gwinn M.L., Hickey E.K., Clayton R.A., Ketchum K.A.,
RA   Sodergren E., Hardham J.M., McLeod M.P., Salzberg S.L., Peterson J.D.,
RA   Khalak H.G., Richardson D.L., Howell J.K., Chidambaram M., Utterback T.R.,
RA   McDonald L.A., Artiach P., Bowman C., Cotton M.D., Fujii C., Garland S.A.,
RA   Hatch B., Horst K., Roberts K.M., Sandusky M., Weidman J.F., Smith H.O.,
RA   Venter J.C.;
RT   "Complete genome sequence of Treponema pallidum, the syphilis spirochete.";
RL   Science 281:375-388(1998).
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE000520; AAC65115.1; -; Genomic_DNA.
DR   PIR; B71364; B71364.
DR   AlphaFoldDB; O83160; -.
DR   SMR; O83160; -.
DR   STRING; 243276.TPANIC_0123; -.
DR   PRIDE; O83160; -.
DR   EnsemblBacteria; AAC65115; AAC65115; TP_0123.
DR   KEGG; tpa:TP_0123; -.
DR   eggNOG; COG0457; Bacteria.
DR   HOGENOM; CLU_347775_0_0_12; -.
DR   OMA; NITEYLW; -.
DR   Proteomes; UP000000811; Chromosome.
DR   Gene3D; 1.25.40.10; -; 1.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   SUPFAM; SSF48452; SSF48452; 1.
PE   4: Predicted;
KW   Reference proteome; Repeat; TPR repeat.
FT   CHAIN           1..856
FT                   /note="TPR repeat-containing protein TP_0123"
FT                   /id="PRO_0000106453"
FT   REPEAT          107..140
FT                   /note="TPR 1"
FT   REPEAT          523..556
FT                   /note="TPR 2"
FT   REPEAT          603..636
FT                   /note="TPR 3"
SQ   SEQUENCE   856 AA;  97894 MW;  7C4B85E2F2463278 CRC64;
     MSLSPQGADM SGVLYLGRFT LCLLPVSCFS QKVMTCADTV RGAQEVFMLC IYVELPYYYQ
     LTRIFPADIE SLCARMRRFA VHNGAALHEA SSVRIFAFEA HSLGSVYAAV RCVRALYQTL
     DTYEKQVKEF RILMDVVADD ASPCLIEDRF HAYRSTLIPD RGFFASFRAK QLLKHYLEFL
     PLPALNMYQV NGFLSLCAEK PFPQGVTTHC IVVRTTSSYM SALCNFMALH PLSEAVYSTL
     SEETRAFFFH LRAAVSFFKR RRYDSSFPQY LTDAFLQYVG LYFKLYYEAA PNAAPPPIYV
     DPCAGHESQK QAEKVLIVSP HSPLMRLPAS CADIEAIPQD LAEVMYTLSL ASRYIFADEI
     EEFFLFLKKH ADFVGDLFDK MFCTQVTMVP HNAYAIPEDV HDSLEKRVRV KMPVIRECIS
     SFLWKKYQEG SLCASTDLLR TFQELQYKYT SDCVLHSLFH TYSDVQIAHL QVEEYTGTDV
     GAVLKVYQHT LLVGMREDAE AAFREAKACL TTLQARRFVS AEYRTFSLLG FLTIGQSKFE
     DALVYFGYAL DDAEQLRDGD FLCSALFHLS ITYFLQHNFT QARLFLSKLS DAISTYFEQR
     WKTVSLFMQG RISLSLGEYA QARRCFDEAA DFALQYFEHQ EPLCRVWAAH ARLLADKSYA
     AHALFQDMCD QYPDAYLFLV ESYVRAECFD DPTLFQSFPE ETTSREPCVP SFSLDTPIYS
     GFSCAEDLVW GRQCAFAVSA QHSTVFAHYY HCRVHLHRAE DMQTFHHHKQ KLEAIARRAF
     QIGDPSAALF LYLCYDVSYR VHGAEAAVTT AHLSRAFKVM QRSVAYMSEN TVRAQFMQDN
     FWNAKLFAAA QANKLI