ID   Y1246_ENTFA             Reviewed;         152 AA.
AC   Q835X3;
DT   24-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=UPF0756 membrane protein EF_1246 {ECO:0000255|HAMAP-Rule:MF_01874};
GN   OrderedLocusNames=EF_1246;
OS   Enterococcus faecalis (strain ATCC 700802 / V583).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Enterococcaceae;
OC   Enterococcus.
OX   NCBI_TaxID=226185;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700802 / V583;
RX   PubMed=12663927; DOI=10.1126/science.1080613;
RA   Paulsen I.T., Banerjei L., Myers G.S.A., Nelson K.E., Seshadri R.,
RA   Read T.D., Fouts D.E., Eisen J.A., Gill S.R., Heidelberg J.F., Tettelin H.,
RA   Dodson R.J., Umayam L.A., Brinkac L.M., Beanan M.J., Daugherty S.C.,
RA   DeBoy R.T., Durkin S.A., Kolonay J.F., Madupu R., Nelson W.C.,
RA   Vamathevan J.J., Tran B., Upton J., Hansen T., Shetty J., Khouri H.M.,
RA   Utterback T.R., Radune D., Ketchum K.A., Dougherty B.A., Fraser C.M.;
RT   "Role of mobile DNA in the evolution of vancomycin-resistant Enterococcus
RT   faecalis.";
RL   Science 299:2071-2074(2003).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_01874};
CC       Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01874}.
CC   -!- SIMILARITY: Belongs to the UPF0756 family. {ECO:0000255|HAMAP-
CC       Rule:MF_01874}.
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DR   EMBL; AE016830; AAO81042.1; -; Genomic_DNA.
DR   RefSeq; NP_814972.1; NC_004668.1.
DR   RefSeq; WP_002357887.1; NZ_KE136528.1.
DR   AlphaFoldDB; Q835X3; -.
DR   EnsemblBacteria; AAO81042; AAO81042; EF_1246.
DR   KEGG; efa:EF1246; -.
DR   PATRIC; fig|226185.45.peg.2254; -.
DR   eggNOG; COG2707; Bacteria.
DR   HOGENOM; CLU_125889_1_0_9; -.
DR   OMA; SKGINWG; -.
DR   Proteomes; UP000001415; Chromosome.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01874; UPF0756; 1.
DR   InterPro; IPR007382; UPF0756_TM.
DR   PANTHER; PTHR38452; PTHR38452; 1.
DR   Pfam; PF04284; DUF441; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..152
FT                   /note="UPF0756 membrane protein EF_1246"
FT                   /id="PRO_0000388850"
FT   TRANSMEM        4..24
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01874"
FT   TRANSMEM        52..72
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01874"
FT   TRANSMEM        85..105
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01874"
FT   TRANSMEM        115..135
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01874"
SQ   SEQUENCE   152 AA;  16019 MW;  C2161F39A18DC042 CRC64;
     MESWLFLLLI ALIAFVAKNQ SLLIASVVVL ALKALPNSAK IMSWLSDKGI NLGVTIISIT
     ILVPIATGQI GLKDLIQSFK TPMGWLGILC GILVAVLSSK GVGLINQSPE ITVALVFGTI
     LGVVFLKGIA AGPIIASGMM YVIITTFQAF QH