ID   Y1246_HAEIN             Reviewed;         647 AA.
AC   P44135;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 116.
DE   RecName: Full=Uncharacterized protein HI_1246;
GN   OrderedLocusNames=HI_1246;
OS   Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=71421;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=7542800; DOI=10.1126/science.7542800;
RA   Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA   Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA   McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA   Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA   Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA   Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA   Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA   Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT   "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT   Rd.";
RL   Science 269:496-512(1995).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
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DR   EMBL; L42023; AAC22900.1; -; Genomic_DNA.
DR   PIR; I64022; I64022.
DR   RefSeq; NP_439402.1; NC_000907.1.
DR   AlphaFoldDB; P44135; -.
DR   SMR; P44135; -.
DR   STRING; 71421.HI_1246; -.
DR   EnsemblBacteria; AAC22900; AAC22900; HI_1246.
DR   KEGG; hin:HI_1246; -.
DR   PATRIC; fig|71421.8.peg.1298; -.
DR   eggNOG; COG1368; Bacteria.
DR   HOGENOM; CLU_014653_3_1_6; -.
DR   OMA; TQAMMKG; -.
DR   PhylomeDB; P44135; -.
DR   BioCyc; HINF71421:G1GJ1-1276-MON; -.
DR   Proteomes; UP000000579; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008484; F:sulfuric ester hydrolase activity; IEA:InterPro.
DR   Gene3D; 3.40.720.10; -; 1.
DR   InterPro; IPR017850; Alkaline_phosphatase_core_sf.
DR   InterPro; IPR012160; LtaS-like.
DR   InterPro; IPR000917; Sulfatase_N.
DR   Pfam; PF00884; Sulfatase; 1.
DR   PIRSF; PIRSF005091; Mmb_sulf_HI1246; 1.
DR   SUPFAM; SSF53649; SSF53649; 1.
PE   4: Predicted;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..647
FT                   /note="Uncharacterized protein HI_1246"
FT                   /id="PRO_0000078013"
FT   TRANSMEM        14..38
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        61..78
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        90..110
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        140..158
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        178..195
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   647 AA;  72752 MW;  87A0469DDDD3896F CRC64;
     MLVVFTMKKA HSPLFPIFTF VLINLIILSL SRLGLAVWQS ERVSAVDGWL QLFLQGVRMD
     VVALCYLFGV PALLTTLFHS SKVWVKILRL WLTFGSVFII FMEIATPAFI ETYDYRPNRL
     FIEYLIYPKE VFSMLAEGHL SAVIFSLVFT ILAAVIYWKI SGWAVKNLRS MSWKLRPVIA
     LLVIVVSFLG ARSSFQHRGI NPAMVAFSSD ALVNSLVLNS GYSVIYAAQQ FKDEEKSSEM
     YGKMDADEMF RIVKASRGRP ESDYISDKYP TLTKNVATYQ GKPKNIVILL QESLGAQFIG
     TLGGKPLSPN VDQLAKEGWL FENLYATGTR SVRGIEATTA GFTPTPARAV VKLNNAQSGF
     FTIADLLHKQ GYNTSFIYGG EKHFDNMASF FYGNGFKDIW DQQDYQNPKF TGTWGVSDED
     LFDKANETFT KLQNEGKPFF SLVFSSSNHD PFEYPDGKIE LYEQPKATRN NAAKYADYAL
     GHFFKMAKQS NYWKDTIFLI IADHDSRVGG ASLVPIKHFH IPALILGDGI TPRRDSRLVS
     QIDMPTTLLS LAGVSGNYPM IGFDLTQDVN PDRAFMQYDQ TQAMMKGNND VVIQMPNKAA
     QGYHYDKSTE TLTPKDVPDA MKKEALAHAL LGSYLYKNRL YSSGENK