ID   Y1246_STRP6             Reviewed;         279 AA.
AC   Q5XB32;
DT   30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   30-AUG-2005, sequence version 2.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=DegV domain-containing protein M6_Spy1246;
GN   OrderedLocusNames=M6_Spy1246;
OS   Streptococcus pyogenes serotype M6 (strain ATCC BAA-946 / MGAS10394).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=286636;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-946 / MGAS10394;
RX   PubMed=15272401; DOI=10.1086/422697;
RA   Banks D.J., Porcella S.F., Barbian K.D., Beres S.B., Philips L.E.,
RA   Voyich J.M., DeLeo F.R., Martin J.M., Somerville G.A., Musser J.M.;
RT   "Progress toward characterization of the group A Streptococcus metagenome:
RT   complete genome sequence of a macrolide-resistant serotype M6 strain.";
RL   J. Infect. Dis. 190:727-738(2004).
CC   -!- FUNCTION: May bind long-chain fatty acids, such as palmitate, and may
CC       play a role in lipid transport or fatty acid metabolism. {ECO:0000250}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAT87381.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP000003; AAT87381.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_002989125.1; NC_006086.1.
DR   AlphaFoldDB; Q5XB32; -.
DR   SMR; Q5XB32; -.
DR   EnsemblBacteria; AAT87381; AAT87381; M6_Spy1246.
DR   KEGG; spa:M6_Spy1246; -.
DR   HOGENOM; CLU_048251_3_2_9; -.
DR   Proteomes; UP000001167; Chromosome.
DR   GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.1180.10; -; 1.
DR   InterPro; IPR003797; DegV.
DR   InterPro; IPR043168; DegV_C.
DR   Pfam; PF02645; DegV; 1.
DR   TIGRFAMs; TIGR00762; DegV; 1.
DR   PROSITE; PS51482; DEGV; 1.
PE   3: Inferred from homology;
KW   Lipid-binding.
FT   CHAIN           1..279
FT                   /note="DegV domain-containing protein M6_Spy1246"
FT                   /id="PRO_0000209806"
FT   DOMAIN          4..278
FT                   /note="DegV"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00815"
FT   BINDING         62
FT                   /ligand="hexadecanoate"
FT                   /ligand_id="ChEBI:CHEBI:7896"
FT                   /evidence="ECO:0000250|UniProtKB:Q9X1H9"
FT   BINDING         95
FT                   /ligand="hexadecanoate"
FT                   /ligand_id="ChEBI:CHEBI:7896"
FT                   /evidence="ECO:0000250|UniProtKB:Q9X1H9"
SQ   SEQUENCE   279 AA;  29952 MW;  9DADBF96BD822A0D CRC64;
     MGTIKIVTDS SITIEPELIK ALDITVVPLS VMIDSKLYSD NDLKEEGHFL SLMKASKSLP
     KTSQPPVGLF AETYENLVKK GVTDIVAIHL SPALSGTIEA SRQGAEIAEA PVTVLDSGFT
     DQAMKFQVVE AAKMAKAGAS LNEILAAVQA IKSKTELYIG VSTLENLVKG GRIGRVTGVL
     SSLLNVKVVM ALKNDELKTL VKGRGNKTFT KWLDSYLAKN SHRPIAEIAI SYAGEASLAL
     TLKERIAAYY NHSISVLETG SIIQTHTGEG AFAVMVRYE