Y1250_MYCTO
ID Y1250_MYCTO Reviewed; 579 AA.
AC P9WG86; L0T635; O50465; Q7D8I7;
DT 16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT 16-APR-2014, sequence version 1.
DT 25-MAY-2022, entry version 37.
DE RecName: Full=Uncharacterized MFS-type transporter MT1289;
GN OrderedLocusNames=MT1289;
OS Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=83331;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CDC 1551 / Oshkosh;
RX PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT laboratory strains.";
RL J. Bacteriol. 184:5479-5490(2002).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. EmrB family.
CC {ECO:0000305}.
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DR EMBL; AE000516; AAK45547.1; -; Genomic_DNA.
DR PIR; A70954; A70954.
DR RefSeq; WP_003898791.1; NZ_KK341227.1.
DR AlphaFoldDB; P9WG86; -.
DR SMR; P9WG86; -.
DR EnsemblBacteria; AAK45547; AAK45547; MT1289.
DR KEGG; mtc:MT1289; -.
DR HOGENOM; CLU_000960_28_1_11; -.
DR Proteomes; UP000001020; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR004638; EmrB-like.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR TIGRFAMs; TIGR00711; efflux_EmrB; 1.
DR PROSITE; PS50850; MFS; 1.
PE 3: Inferred from homology;
KW Cell membrane; Membrane; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..579
FT /note="Uncharacterized MFS-type transporter MT1289"
FT /id="PRO_0000428405"
FT TRANSMEM 20..40
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 54..74
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 86..106
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 142..162
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 174..194
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 204..224
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 234..254
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 279..299
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 310..330
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 335..355
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 366..386
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 467..487
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 516..579
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 579 AA; 60908 MW; A56979E3DE788694 CRC64;
MTTAIRRAAG SSYFRNPWPA LWAMMVGFFM IMLDSTVVAI ANPTIMAQLR IGYATVVWVT
SAYLLAYAVP MLVAGRLGDR FGPKNLYLIG LGVFTVASLG CGLSSGAGML IAARVVQGVG
AGLLTPQTLS TITRIFPAHR RGVALGAWGT VASVASLVGP LAGGALVDSM GWEWIFFVNV
PVGVIGLILA AYLIPALPHH PHRFDWFGVG LSGAGMFLIV FGLQQGQSAN WQPWIWAVIV
GGIGFMSLFV YWQARNAREP LIPLEVFNDR NFSLSNLRIA IIAFAGTGMM LPVTFYAQAV
CGLSPTHTAV LFAPTAIVGG VLAPFVGMII DRSHPLCVLG FGFSVLAIAM TWLLCEMAPG
TPIWRLVLPF IALGVAGAFV WSPLTVTATR NLRPHLAGAS SGVFNAVRQL GAVLGSASMA
AFMTSRIAAE MPGGVDALTG PAGQDATVLQ LPEFVREPFA AAMSQSMLLP AFVALFGIVA
ALFLVDFTGA AVAKEPLPES DGDADDDDYV EYILRREPEE DCDTQPLRAS RPAAAAASRS
GAGGPLAVSW STSAQGMPPG PPGRRAWQAD TESTAPSAL