ID   Y1250_MYCTU             Reviewed;         579 AA.
AC   P9WG87; L0T635; O50465; Q7D8I7;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 39.
DE   RecName: Full=Uncharacterized MFS-type transporter Rv1250;
GN   OrderedLocusNames=Rv1250;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily. EmrB family.
CC       {ECO:0000305}.
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DR   EMBL; AL123456; CCP44006.1; -; Genomic_DNA.
DR   PIR; A70954; A70954.
DR   RefSeq; NP_215766.1; NC_000962.3.
DR   RefSeq; WP_003898791.1; NZ_NVQJ01000049.1.
DR   AlphaFoldDB; P9WG87; -.
DR   SMR; P9WG87; -.
DR   STRING; 83332.Rv1250; -.
DR   PaxDb; P9WG87; -.
DR   DNASU; 887073; -.
DR   GeneID; 887073; -.
DR   KEGG; mtu:Rv1250; -.
DR   PATRIC; fig|83332.12.peg.1399; -.
DR   TubercuList; Rv1250; -.
DR   eggNOG; COG0477; Bacteria.
DR   OMA; GNICYGA; -.
DR   PhylomeDB; P9WG87; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; HDA:MTBBASE.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 1.20.1250.20; -; 1.
DR   InterPro; IPR004638; EmrB-like.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   TIGRFAMs; TIGR00711; efflux_EmrB; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..579
FT                   /note="Uncharacterized MFS-type transporter Rv1250"
FT                   /id="PRO_0000390688"
FT   TRANSMEM        20..40
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        54..74
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        86..106
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        142..162
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        174..194
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        204..224
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        234..254
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        279..299
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        310..330
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        335..355
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        366..386
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        467..487
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          516..579
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   579 AA;  60908 MW;  A56979E3DE788694 CRC64;
     MTTAIRRAAG SSYFRNPWPA LWAMMVGFFM IMLDSTVVAI ANPTIMAQLR IGYATVVWVT
     SAYLLAYAVP MLVAGRLGDR FGPKNLYLIG LGVFTVASLG CGLSSGAGML IAARVVQGVG
     AGLLTPQTLS TITRIFPAHR RGVALGAWGT VASVASLVGP LAGGALVDSM GWEWIFFVNV
     PVGVIGLILA AYLIPALPHH PHRFDWFGVG LSGAGMFLIV FGLQQGQSAN WQPWIWAVIV
     GGIGFMSLFV YWQARNAREP LIPLEVFNDR NFSLSNLRIA IIAFAGTGMM LPVTFYAQAV
     CGLSPTHTAV LFAPTAIVGG VLAPFVGMII DRSHPLCVLG FGFSVLAIAM TWLLCEMAPG
     TPIWRLVLPF IALGVAGAFV WSPLTVTATR NLRPHLAGAS SGVFNAVRQL GAVLGSASMA
     AFMTSRIAAE MPGGVDALTG PAGQDATVLQ LPEFVREPFA AAMSQSMLLP AFVALFGIVA
     ALFLVDFTGA AVAKEPLPES DGDADDDDYV EYILRREPEE DCDTQPLRAS RPAAAAASRS
     GAGGPLAVSW STSAQGMPPG PPGRRAWQAD TESTAPSAL