ID   Y1255_MYCTU             Reviewed;         202 AA.
AC   P9WMD5; L0T641; Q11063;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 40.
DE   RecName: Full=Uncharacterized HTH-type transcriptional regulator Rv1255c;
GN   OrderedLocusNames=Rv1255c; ORFNames=MTCY50.27;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
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DR   EMBL; AL123456; CCP44011.1; -; Genomic_DNA.
DR   PIR; G70752; G70752.
DR   RefSeq; NP_215771.1; NC_000962.3.
DR   RefSeq; WP_003406350.1; NZ_NVQJ01000049.1.
DR   AlphaFoldDB; P9WMD5; -.
DR   SMR; P9WMD5; -.
DR   STRING; 83332.Rv1255c; -.
DR   PaxDb; P9WMD5; -.
DR   DNASU; 887068; -.
DR   GeneID; 45425225; -.
DR   GeneID; 887068; -.
DR   KEGG; mtu:Rv1255c; -.
DR   TubercuList; Rv1255c; -.
DR   eggNOG; COG1309; Bacteria.
DR   OMA; YVHRETH; -.
DR   PhylomeDB; P9WMD5; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR   GO; GO:0000976; F:transcription cis-regulatory region binding; IBA:GO_Central.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001647; HTH_TetR.
DR   Pfam; PF00440; TetR_N; 1.
DR   PRINTS; PR00455; HTHTETR.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS50977; HTH_TETR_2; 1.
PE   1: Evidence at protein level;
KW   DNA-binding; Reference proteome; Repeat; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..202
FT                   /note="Uncharacterized HTH-type transcriptional regulator
FT                   Rv1255c"
FT                   /id="PRO_0000070660"
FT   DOMAIN          13..73
FT                   /note="HTH tetR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00335"
FT   DNA_BIND        36..55
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00335"
SQ   SEQUENCE   202 AA;  22223 MW;  78934C8E146DC0BB CRC64;
     MAGTDWLSAR RTELAADRIL DAAERLFTQR DPASIGMNEI AKAAGCSRAT LYRYFDSREA
     LRTAYVHRET RRLGREIMVK IADVVEPAER LLVSITTTLR MVRDNPALAA WFTTTRPPIG
     GEMAGRSEVI AALAAAFLNS LGPDDPTTVE RRARWVVRML TSLLMFPGRD EADERAMIAE
     FVVPIVTPAS AAARKAGHPG PE