ID   Y125_HAEIN              Reviewed;         438 AA.
AC   P44530;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 107.
DE   RecName: Full=Putative permease HI_0125;
GN   OrderedLocusNames=HI_0125;
OS   Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=71421;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=7542800; DOI=10.1126/science.7542800;
RA   Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA   Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA   McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA   Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA   Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA   Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA   Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA   Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT   "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT   Rd.";
RL   Science 269:496-512(1995).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC
CC       2.A.40) family. Azg-like subfamily. {ECO:0000305}.
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DR   EMBL; L42023; AAC21799.1; -; Genomic_DNA.
DR   PIR; C64143; C64143.
DR   RefSeq; NP_438297.1; NC_000907.1.
DR   RefSeq; WP_005694416.1; NC_000907.1.
DR   AlphaFoldDB; P44530; -.
DR   STRING; 71421.HI_0125; -.
DR   EnsemblBacteria; AAC21799; AAC21799; HI_0125.
DR   KEGG; hin:HI_0125; -.
DR   PATRIC; fig|71421.8.peg.129; -.
DR   eggNOG; COG2252; Bacteria.
DR   HOGENOM; CLU_024508_0_1_6; -.
DR   OMA; PDAMGMV; -.
DR   PhylomeDB; P44530; -.
DR   BioCyc; HINF71421:G1GJ1-138-MON; -.
DR   Proteomes; UP000000579; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0015208; F:guanine transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0005345; F:purine nucleobase transmembrane transporter activity; IBA:GO_Central.
DR   InterPro; IPR045018; Azg-like.
DR   InterPro; IPR006043; NCS2.
DR   PANTHER; PTHR43337; PTHR43337; 1.
DR   Pfam; PF00860; Xan_ur_permease; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cell membrane; Membrane; Nucleotide-binding;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..438
FT                   /note="Putative permease HI_0125"
FT                   /id="PRO_0000169722"
FT   TRANSMEM        21..41
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        51..71
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        73..93
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        97..117
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        137..157
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        167..187
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        195..215
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        238..258
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        296..316
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        326..346
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        347..367
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        386..406
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        418..438
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   BINDING         315..322
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   438 AA;  45298 MW;  CAA1801D1B33D473 CRC64;
     MPTLEKTFEL KQRGSTVRQE IIAGLTTFLA MVYSVIVVPN MLGAAGFPAE SVFIATCLVA
     GLGSILIGLW ANAPMAIGCA ISLTAFTAFS LVIGQKVAIP VALGAVFLMG VVFTLISTTG
     IRAWILRNLP SNIAHGAGIG IGLFLLLIAA NGVGLVVSNQ AGLPVKLGDF TSFPVMMSLI
     GLALIIGLEK MKIKGGILWV IIAITIVGLI FDPNVKFGGE IFKMPTFGEN SLFLQLDFMG
     ALQPAILPVV FALVMTAVFD ATGTIRAVAG QADLLDKDGQ IINGGKALTS DSISSLFSGL
     FGTAPAAVYI ESAAGTAAGG KTGITAIVVG VLFLLMLFFQ PLAFLVPGYA TAPALMYVGL
     LMLSNVSKLD FDDFVGAMSG LICAVFIVLT ANIVTGIMLG FAALVIGRIV SGDIKRLNVG
     TVIIAIVLVA FYAGGWAI