ID   Y1279_MYCTU             Reviewed;         528 AA.
AC   P9WMV5; L0T7T5; P64263; Q11038;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   03-AUG-2022, entry version 42.
DE   RecName: Full=Uncharacterized GMC-type oxidoreductase Rv1279;
DE            EC=1.1.-.-;
GN   OrderedLocusNames=Rv1279; ORFNames=MTCY50.03c;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000250};
CC   -!- SIMILARITY: Belongs to the GMC oxidoreductase family. {ECO:0000305}.
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DR   EMBL; AL123456; CCP44035.1; -; Genomic_DNA.
DR   PIR; G70755; G70755.
DR   RefSeq; NP_215795.1; NC_000962.3.
DR   RefSeq; WP_003406598.1; NZ_NVQJ01000030.1.
DR   AlphaFoldDB; P9WMV5; -.
DR   SMR; P9WMV5; -.
DR   STRING; 83332.Rv1279; -.
DR   PaxDb; P9WMV5; -.
DR   DNASU; 887002; -.
DR   GeneID; 887002; -.
DR   KEGG; mtu:Rv1279; -.
DR   TubercuList; Rv1279; -.
DR   eggNOG; COG2303; Bacteria.
DR   OMA; NEGVGYF; -.
DR   PhylomeDB; P9WMV5; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0005829; C:cytosol; HDA:MTBBASE.
DR   GO; GO:0009274; C:peptidoglycan-based cell wall; HDA:MTBBASE.
DR   GO; GO:0005886; C:plasma membrane; HDA:MTBBASE.
DR   GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR   GO; GO:0016614; F:oxidoreductase activity, acting on CH-OH group of donors; IEA:InterPro.
DR   Gene3D; 3.50.50.60; -; 1.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR012132; GMC_OxRdtase.
DR   InterPro; IPR000172; GMC_OxRdtase_N.
DR   InterPro; IPR007867; GMC_OxRtase_C.
DR   PANTHER; PTHR11552; PTHR11552; 1.
DR   Pfam; PF05199; GMC_oxred_C; 1.
DR   Pfam; PF00732; GMC_oxred_N; 1.
DR   PIRSF; PIRSF000137; Alcohol_oxidase; 1.
DR   SUPFAM; SSF51905; SSF51905; 1.
DR   PROSITE; PS00623; GMC_OXRED_1; 1.
DR   PROSITE; PS00624; GMC_OXRED_2; 1.
PE   1: Evidence at protein level;
KW   FAD; Flavoprotein; Oxidoreductase; Reference proteome.
FT   CHAIN           1..528
FT                   /note="Uncharacterized GMC-type oxidoreductase Rv1279"
FT                   /id="PRO_0000205616"
FT   ACT_SITE        468
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000250|UniProtKB:E4QP00"
FT   BINDING         6..35
FT                   /ligand="FAD"
FT                   /ligand_id="ChEBI:CHEBI:57692"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   528 AA;  57331 MW;  9177AD391F994CB6 CRC64;
     MDTQSDYVVV GTGSAGAVVA SRLSTDPATT VVALEAGPRD KNRFIGVPAA FSKLFRSEID
     WDYLTEPQPE LDGREIYWPR GKVLGGSSSM NAMMWVRGFA SDYDEWAARA GPRWSYADVL
     GYFRRIENVT AAWHFVSGDD SGVTGPLHIS RQRSPRSVTA AWLAAARECG FAAARPNSPR
     PEGFCETVVT QRRGARFSTA DAYLKPAMRR KNLRVLTGAT ATRVVIDGDR AVGVEYQSDG
     QTRIVYARRE VVLCAGAVNS PQLLMLSGIG DRDHLAEHDI DTVYHAPEVG CNLLDHLVTV
     LGFDVEKDSL FAAEKPGQLI SYLLRRRGML TSNVGEAYGF VRSRPELKLP DLELIFAPAP
     FYDEALVPPA GHGVVFGPIL VAPQSRGQIT LRSADPHAKP VIEPRYLSDL GGVDRAAMMA
     GLRICARIAQ ARPLRDLLGS IARPRNSTEL DEATLELALA TCSHTLYHPM GTCRMGSDEA
     SVVDPQLRVR GVDGLRVADA SVMPSTVRGH THAPSVLIGE KAADLIRS