ID   Y1280_MYCTU             Reviewed;         591 AA.
AC   P9WGU5; L0T665; P66771; Q11041;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 47.
DE   RecName: Full=Uncharacterized protein Rv1280c;
GN   OrderedLocusNames=Rv1280c; ORFNames=MTCY50.02;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the bacterial solute-binding protein 5 family.
CC       {ECO:0000305}.
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DR   EMBL; AL123456; CCP44036.1; -; Genomic_DNA.
DR   PIR; H70755; H70755.
DR   RefSeq; NP_215796.1; NC_000962.3.
DR   RefSeq; WP_003900310.1; NZ_NVQJ01000030.1.
DR   AlphaFoldDB; P9WGU5; -.
DR   SMR; P9WGU5; -.
DR   STRING; 83332.Rv1280c; -.
DR   PaxDb; P9WGU5; -.
DR   DNASU; 886985; -.
DR   GeneID; 45425252; -.
DR   GeneID; 886985; -.
DR   KEGG; mtu:Rv1280c; -.
DR   TubercuList; Rv1280c; -.
DR   eggNOG; COG0747; Bacteria.
DR   OMA; WTARNAG; -.
DR   PhylomeDB; P9WGU5; -.
DR   Reactome; R-HSA-1222538; Tolerance by Mtb to nitric oxide produced by macrophages.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0043190; C:ATP-binding cassette (ABC) transporter complex; IEA:InterPro.
DR   GO; GO:0005887; C:integral component of plasma membrane; HDA:MTBBASE.
DR   GO; GO:0030288; C:outer membrane-bounded periplasmic space; IBA:GO_Central.
DR   GO; GO:0042597; C:periplasmic space; TAS:Reactome.
DR   GO; GO:0005886; C:plasma membrane; HDA:MTBBASE.
DR   GO; GO:0043295; F:glutathione binding; IDA:MTBBASE.
DR   GO; GO:0042277; F:peptide binding; IDA:MTBBASE.
DR   GO; GO:1904680; F:peptide transmembrane transporter activity; IDA:MTBBASE.
DR   GO; GO:0015833; P:peptide transport; IBA:GO_Central.
DR   GO; GO:0017038; P:protein import; IDA:MTBBASE.
DR   InterPro; IPR030678; Peptide/Ni-bd.
DR   InterPro; IPR039424; SBP_5.
DR   InterPro; IPR000914; SBP_5_dom.
DR   PANTHER; PTHR30290; PTHR30290; 1.
DR   Pfam; PF00496; SBP_bac_5; 1.
DR   PIRSF; PIRSF002741; MppA; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..591
FT                   /note="Uncharacterized protein Rv1280c"
FT                   /id="PRO_0000062776"
FT   TRANSMEM        34..54
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   591 AA;  63477 MW;  E63F417047BE91CE CRC64;
     MADRGQRRGC APGIASALRA SFQGKSRPWT QTRYWAFALL TPLVVAMVLT GCSASGTQLE
     LAPTADRRAA VGTTSDINQQ DPATLQDGGN LRLSLTDFPP NFNILHIDGN NAEVAAMMKA
     TLPRAFIIGP DGSTTVDTNY FTSIELTRTA PQVVTYTINP EAVWSDGTPI TWRDIASQIH
     AISGADKAFE IASSSGAERV ASVTRGVDDR QAVVTFAKPY AEWRGMFAGN GMLLPASMTA
     TPEAFNKGQL DGPGPSAGPF VVSALDRTAQ RIVLTRNPRW WGARPRLDSI TYLVLDDAAR
     LPALQNNTID ATGVGTLDQL TIAARTKGIS IRRAPGPSWY HFTLNGAPGS ILADKALRLA
     IAKGIDRYTI ARVAQYGLTS DPVPLNNHVF VAGQDGYQDN SGVVAYNPEQ AKRELDALGW
     RRSGAFREKD GRQLVIRDLF YDAQSTRQFA QIAQHTLAQI GVKLELQAKS GSGFFSDYVN
     VGAFDIAQFG WVGDAFPLSS LTQIYASDGE SNFGKIGSPQ IDAAIERTLA ELDPGKARAL
     ANQVDELIWA EGFSLPLTQS PGTVAVRSTL ANFGATGLAD LDYTAIGFMR R