ID   Y1281_MYCTU             Reviewed;         612 AA.
AC   P9WQJ5; L0T6E3; P63395; Q11040;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   03-AUG-2022, entry version 54.
DE   RecName: Full=Uncharacterized ABC transporter ATP-binding protein Rv1281c;
GN   OrderedLocusNames=Rv1281c; ORFNames=MTCY50.01;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- SIMILARITY: Belongs to the ABC transporter superfamily. {ECO:0000305}.
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DR   EMBL; AL123456; CCP44037.1; -; Genomic_DNA.
DR   PIR; A70756; A70756.
DR   RefSeq; NP_215797.1; NC_000962.3.
DR   RefSeq; WP_003406602.1; NZ_NVQJ01000030.1.
DR   AlphaFoldDB; P9WQJ5; -.
DR   STRING; 83332.Rv1281c; -.
DR   PaxDb; P9WQJ5; -.
DR   DNASU; 886997; -.
DR   GeneID; 886997; -.
DR   KEGG; mtu:Rv1281c; -.
DR   TubercuList; Rv1281c; -.
DR   eggNOG; COG4172; Bacteria.
DR   OMA; DPMTRLD; -.
DR   PhylomeDB; P9WQJ5; -.
DR   Reactome; R-HSA-1222538; Tolerance by Mtb to nitric oxide produced by macrophages.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0009274; C:peptidoglycan-based cell wall; HDA:MTBBASE.
DR   GO; GO:0005886; C:plasma membrane; HDA:MTBBASE.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0015833; P:peptide transport; IEA:InterPro.
DR   GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR   Gene3D; 3.40.50.300; -; 2.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR   InterPro; IPR017871; ABC_transporter-like_CS.
DR   InterPro; IPR013563; Oligopep_ABC_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF00005; ABC_tran; 2.
DR   Pfam; PF08352; oligo_HPY; 2.
DR   SMART; SM00382; AAA; 2.
DR   SUPFAM; SSF52540; SSF52540; 2.
DR   TIGRFAMs; TIGR01727; oligo_HPY; 1.
DR   PROSITE; PS00211; ABC_TRANSPORTER_1; 2.
DR   PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE   1: Evidence at protein level;
KW   ATP-binding; Nucleotide-binding; Reference proteome; Repeat; Transport.
FT   CHAIN           1..612
FT                   /note="Uncharacterized ABC transporter ATP-binding protein
FT                   Rv1281c"
FT                   /id="PRO_0000093259"
FT   DOMAIN          5..255
FT                   /note="ABC transporter 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT   DOMAIN          350..600
FT                   /note="ABC transporter 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT   BINDING         41..48
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT   BINDING         394..401
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
SQ   SEQUENCE   612 AA;  65293 MW;  9E03D437C6EF0992 CRC64;
     MSPLLEVTDL AVTFRTDGDP VTAVRGISYR VEPGEVVAMV GESGSGKSAA AMAVVGLLPE
     YAQVRGSVRL QGTELLGLAD NAMSRFRGKA IGTVFQDPMS ALTPVYTVGD QIAEAIEVHQ
     PRVGKKAARR RAVELLDLVG ISQPQRRSRA FPHELSGGER QRVVIAIAIA NDPDLLICDE
     PTTALDVTVQ AQILDVLKAA RDVTGAGVLI ITHDLGVVAE FADRALVMYA GRVVESAGVN
     DLYRDRRMPY TVGLLGSVPR LDAAQGTRLV PIPGAPPSLA GLAPGCPFAP RCPLVIDECL
     TAEPELLDVA TDHRAACIRT ELVTGRSAAD IYRVKTEARP AALGDASVVV RVRHLVKTYR
     LAKGVVLRRA IGEVRAVDGI SLELRQGRTL GIVGESGSGK STTLHEILEL AAPQSGSIEV
     LGTDVATLGT AERRSLRRDI QVVFQDPVAS LDPRLPVFDL IAEPLQANGF GKNETHARVA
     ELLDIVGLRH GDASRYPAEF SGGQKQRIGI ARALALQPKI LALDEPVSAL DVSIQAGIIN
     LLLDLQEQFG LSYLFVSHDL SVVKHLAHQV AVMLAGTVVE QGDSEEVFGN PKHEYTRRLL
     GAVPQPDPAR RG