ID   Y1290_MYCTU             Reviewed;         521 AA.
AC   P9WM35; L0T676; P0A5E3; Q10616;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 33.
DE   RecName: Full=Uncharacterized protein Rv1290c;
GN   OrderedLocusNames=Rv1290c; ORFNames=MTCY373.09c;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AL123456; CCP44046.1; -; Genomic_DNA.
DR   PIR; F70772; F70772.
DR   RefSeq; NP_215806.1; NC_000962.3.
DR   RefSeq; WP_003406627.1; NZ_NVQJ01000030.1.
DR   AlphaFoldDB; P9WM35; -.
DR   STRING; 83332.Rv1290c; -.
DR   PaxDb; P9WM35; -.
DR   DNASU; 886971; -.
DR   GeneID; 886971; -.
DR   KEGG; mtu:Rv1290c; -.
DR   TubercuList; Rv1290c; -.
DR   eggNOG; COG4325; Bacteria.
DR   OMA; YVQHIDM; -.
DR   PhylomeDB; P9WM35; -.
DR   PHI-base; PHI:3643; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0005829; C:cytosol; HDA:MTBBASE.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR018723; DUF2254_membrane.
DR   Pfam; PF10011; DUF2254; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..521
FT                   /note="Uncharacterized protein Rv1290c"
FT                   /id="PRO_0000103789"
FT   TRANSMEM        68..88
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        114..134
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        160..180
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        192..212
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        290..310
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        399..419
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..25
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   521 AA;  56028 MW;  0A4BC9FEC7E86AD5 CRC64;
     MLQRSLGVNG RKLAMSARSA KRERKNASTA ASKCYVVPPS ARGWVHAYSV TATSMLNRRK
     AILDYLQGAV WVLPTFGVAI GLGSGAVLSM IPVKSGTLID KLMFQGTPGD ARGVLIVVSA
     TMITTIGIVF SLTVLSLQIA SSQFSVRLLR TFLRDVPNQV VLAIFACTFA YSTGGLHTVG
     EHRDGGAFIP KVAVTGSLAL AFVSIAALIY FLHHLMHSIQ IDTIMDKVRL RTLGLVDQLY
     PESDTADRQV ETPPSPPADA VPLLAPHSGY LQTVDVDDIA ELAAASRYTA LLVTFVGDYV
     TAGGLLGWCW RRGTAPGAPG SDFPQRCLRH VHIGFERTLQ QDIRFGLRQM VDIALRALSP
     ALNDPYTAIQ VVHHLSAVES VLASRALPDD VRRDRAGELL FWLPYPSFAT YLHVGCAQIR
     RYGSREPLVL TALLQLLSAV AQNCVDPSRR VAVQTQIALV VRAAQREFAD ESDRAMVLGA
     AARATEVVER PGTLAPPPST FGQVAAAQAA ASTIRSADRD G