ID   Y1296_HAEIN             Reviewed;         178 AA.
AC   Q57519; O05055;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 104.
DE   RecName: Full=Uncharacterized endonuclease HI_1296;
DE            EC=3.1.-.-;
DE   Flags: Precursor;
GN   OrderedLocusNames=HI_1296;
OS   Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=71421;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=7542800; DOI=10.1126/science.7542800;
RA   Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA   Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA   McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA   Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA   Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA   Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA   Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA   Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT   "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT   Rd.";
RL   Science 269:496-512(1995).
CC   -!- SIMILARITY: Belongs to the thermonuclease family. {ECO:0000255|PROSITE-
CC       ProRule:PRU00272}.
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DR   EMBL; L42023; AAC22942.1; -; Genomic_DNA.
DR   PIR; A64115; A64115.
DR   RefSeq; NP_439447.2; NC_000907.1.
DR   AlphaFoldDB; Q57519; -.
DR   SMR; Q57519; -.
DR   STRING; 71421.HI_1296; -.
DR   EnsemblBacteria; AAC22942; AAC22942; HI_1296.
DR   KEGG; hin:HI_1296; -.
DR   PATRIC; fig|71421.8.peg.1347; -.
DR   eggNOG; COG1525; Bacteria.
DR   HOGENOM; CLU_046484_7_3_6; -.
DR   OMA; SACSREK; -.
DR   PhylomeDB; Q57519; -.
DR   Proteomes; UP000000579; Chromosome.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   Gene3D; 2.40.50.90; -; 1.
DR   InterPro; IPR035437; SNase_OB-fold_sf.
DR   InterPro; IPR016071; Staphylococal_nuclease_OB-fold.
DR   InterPro; IPR002071; Thermonucl_AS.
DR   Pfam; PF00565; SNase; 1.
DR   SMART; SM00318; SNc; 1.
DR   SUPFAM; SSF50199; SSF50199; 1.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
DR   PROSITE; PS01123; TNASE_1; 1.
DR   PROSITE; PS01284; TNASE_2; 1.
DR   PROSITE; PS50830; TNASE_3; 1.
PE   3: Inferred from homology;
KW   Endonuclease; Hydrolase; Nuclease; Reference proteome; Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT   CHAIN           20..178
FT                   /note="Uncharacterized endonuclease HI_1296"
FT                   /id="PRO_0000034397"
FT   ACT_SITE        52
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        60
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        94
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   178 AA;  20441 MW;  4169580DDFB6B340 CRC64;
     MINRKILLTS LLLIFTVLSA CSREKNTCRV VKISDGDTLT CLTKGNKSIK VRLAEIDAPE
     KSQAFGQKSK KTLSDLVYQK NVRLARKGKD RYQRTLAVVY YQKQNINLEM VKQGMAWAYK
     QYSHDPIYLQ AQENAQAKGI GLWADNNPIE PSQWRRQEKI NMAFDYQTFP SSISLFPT