ID   Y130_ARCFU              Reviewed;         359 AA.
AC   O30107;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=Probable deacetylase AF_0130 {ECO:0000305};
DE            EC=3.5.1.- {ECO:0000250|UniProtKB:Q48935};
GN   OrderedLocusNames=AF_0130;
OS   Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC
OS   100126 / VC-16).
OC   Archaea; Euryarchaeota; Archaeoglobi; Archaeoglobales; Archaeoglobaceae;
OC   Archaeoglobus.
OX   NCBI_TaxID=224325;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16;
RX   PubMed=9389475; DOI=10.1038/37052;
RA   Klenk H.-P., Clayton R.A., Tomb J.-F., White O., Nelson K.E., Ketchum K.A.,
RA   Dodson R.J., Gwinn M.L., Hickey E.K., Peterson J.D., Richardson D.L.,
RA   Kerlavage A.R., Graham D.E., Kyrpides N.C., Fleischmann R.D.,
RA   Quackenbush J., Lee N.H., Sutton G.G., Gill S.R., Kirkness E.F.,
RA   Dougherty B.A., McKenney K., Adams M.D., Loftus B.J., Peterson S.N.,
RA   Reich C.I., McNeil L.K., Badger J.H., Glodek A., Zhou L., Overbeek R.,
RA   Gocayne J.D., Weidman J.F., McDonald L.A., Utterback T.R., Cotton M.D.,
RA   Spriggs T., Artiach P., Kaine B.P., Sykes S.M., Sadow P.W., D'Andrea K.P.,
RA   Bowman C., Fujii C., Garland S.A., Mason T.M., Olsen G.J., Fraser C.M.,
RA   Smith H.O., Woese C.R., Venter J.C.;
RT   "The complete genome sequence of the hyperthermophilic, sulphate-reducing
RT   archaeon Archaeoglobus fulgidus.";
RL   Nature 390:364-370(1997).
CC   -!- FUNCTION: Probable deacetylase. {ECO:0000250|UniProtKB:Q48935}.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000250|UniProtKB:Q48935};
CC       Note=Binds 1 zinc ion per subunit. {ECO:0000250|UniProtKB:Q48935};
CC   -!- SIMILARITY: Belongs to the histone deacetylase family. {ECO:0000305}.
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DR   EMBL; AE000782; AAB91099.1; -; Genomic_DNA.
DR   PIR; B69266; B69266.
DR   RefSeq; WP_010877642.1; NC_000917.1.
DR   AlphaFoldDB; O30107; -.
DR   SMR; O30107; -.
DR   STRING; 224325.AF_0130; -.
DR   EnsemblBacteria; AAB91099; AAB91099; AF_0130.
DR   GeneID; 24793683; -.
DR   KEGG; afu:AF_0130; -.
DR   eggNOG; arCOG00324; Archaea.
DR   HOGENOM; CLU_007727_8_2_2; -.
DR   OMA; CFWHSTG; -.
DR   OrthoDB; 34461at2157; -.
DR   PhylomeDB; O30107; -.
DR   Proteomes; UP000002199; Chromosome.
DR   GO; GO:0004407; F:histone deacetylase activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0016575; P:histone deacetylation; IEA:InterPro.
DR   Gene3D; 3.40.800.20; -; 1.
DR   InterPro; IPR000286; His_deacetylse.
DR   InterPro; IPR003084; His_deacetylse_1.
DR   InterPro; IPR023801; His_deacetylse_dom.
DR   InterPro; IPR037138; His_deacetylse_dom_sf.
DR   InterPro; IPR023696; Ureohydrolase_dom_sf.
DR   Pfam; PF00850; Hist_deacetyl; 1.
DR   PRINTS; PR01270; HDASUPER.
DR   PRINTS; PR01271; HISDACETLASE.
DR   SUPFAM; SSF52768; SSF52768; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Metal-binding; Reference proteome; Zinc.
FT   CHAIN           1..359
FT                   /note="Probable deacetylase AF_0130"
FT                   /id="PRO_0000114744"
FT   ACT_SITE        126
FT                   /note="Proton donor/acceptor"
FT                   /evidence="ECO:0000250|UniProtKB:Q48935"
FT   BINDING         162
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250|UniProtKB:Q48935"
FT   BINDING         164
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250|UniProtKB:Q48935"
FT   BINDING         249
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250|UniProtKB:Q48935"
FT   SITE            293
FT                   /note="Polarizes the scissile carbonyl of the substrate"
FT                   /evidence="ECO:0000250|UniProtKB:Q48935"
SQ   SEQUENCE   359 AA;  40468 MW;  CEC0D294311157AC CRC64;
     MVTGIVFHEE YLKHEQSPTH PERRERLAYT MDQLREEGIF ESERIVLLEP FKASLEDVLE
     VHTEEYVRFL EMESKKGGII DFDTNIPVGV FDRALLAAGG AIRAAQAVLN KECENAFAMI
     RPPGHHAKPY IGAGFCYLNN MAIMVKWLLK QGFERIAILD WDAHHGDGTQ EIFYNDDRVL
     FISTHQMPLY PGTGYPEECG TGKGEGYTVN IPLPPGTGDE GYMMVIDEII EPVVNEFKPQ
     FIAISAGQDN HFTDPITSLA LTARGYAEMM RRAVAMAEKH CDGRLVAVLE GGYSVEGALP
     YTNLGIIAAM AGFDLSAIRE PENYLPELLW RKRDSALVKL KHNIEDVKRV HSKYWKCFK