Y1314_HAEIN
ID Y1314_HAEIN Reviewed; 161 AA.
AC Q57223; O05058;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=Probable endopeptidase HI_1314;
DE EC=3.4.-.-;
DE Flags: Precursor;
GN OrderedLocusNames=HI_1314;
OS Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae; Haemophilus.
OX NCBI_TaxID=71421;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX PubMed=7542800; DOI=10.1126/science.7542800;
RA Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT Rd.";
RL Science 269:496-512(1995).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|PROSITE-
CC ProRule:PRU00303}; Lipid-anchor {ECO:0000255|PROSITE-ProRule:PRU00303}.
CC -!- SIMILARITY: Belongs to the peptidase C40 family. {ECO:0000255|PROSITE-
CC ProRule:PRU01284, ECO:0000305}.
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DR EMBL; L42023; AAC22960.1; -; Genomic_DNA.
DR PIR; H64170; H64170.
DR RefSeq; NP_439465.1; NC_000907.1.
DR RefSeq; WP_010869179.1; NC_000907.1.
DR AlphaFoldDB; Q57223; -.
DR SMR; Q57223; -.
DR STRING; 71421.HI_1314; -.
DR MEROPS; C40.004; -.
DR EnsemblBacteria; AAC22960; AAC22960; HI_1314.
DR KEGG; hin:HI_1314; -.
DR PATRIC; fig|71421.8.peg.1366; -.
DR eggNOG; COG0791; Bacteria.
DR HOGENOM; CLU_016043_9_3_6; -.
DR OMA; WKRAYWQ; -.
DR PhylomeDB; Q57223; -.
DR BioCyc; HINF71421:G1GJ1-1339-MON; -.
DR Proteomes; UP000000579; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR InterPro; IPR000064; NLP_P60_dom.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR Pfam; PF00877; NLPC_P60; 1.
DR SUPFAM; SSF54001; SSF54001; 1.
DR PROSITE; PS51935; NLPC_P60; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 3: Inferred from homology;
KW Cell membrane; Hydrolase; Lipoprotein; Membrane; Palmitate; Protease;
KW Reference proteome; Signal; Thiol protease.
FT SIGNAL 1..18
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT CHAIN 19..161
FT /note="Probable endopeptidase HI_1314"
FT /id="PRO_0000019769"
FT DOMAIN 39..161
FT /note="NlpC/P60"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01284"
FT ACT_SITE 69
FT /note="Nucleophile"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01284"
FT ACT_SITE 122
FT /note="Proton acceptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01284"
FT ACT_SITE 134
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01284"
FT LIPID 19
FT /note="N-palmitoyl cysteine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT LIPID 19
FT /note="S-diacylglycerol cysteine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
SQ SEQUENCE 161 AA; 18388 MW; 7B9C17C50EFCA960 CRC64;
MKVYKSFLIA TASLFLFACS SFQNDDYAMN YKGQIGEPIM AIAMLSEQQH EWAGTPYVLG
GVSRRGVDCS GFVQKTFFDR FNLRLPRSTV EQANYGKHVR KEDIQTGDLI FFKTGRGPNG
YHVGIYVKED KFLHASTRGG VVYSSMNNPY WSKAFWQVRR I
